Fox Chase Cancer Center and the Lewis Katz School of Medicine at Temple University Present Research at the American Association of Cancer Research Annual Meeting 2024

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Fox Chase Cancer Center and the Lewis Katz School of Medicine at Temple University researchers will participate in the presentation and discussion of 16 research projects at the American Association of Cancer Research Annual Meeting 2024.

PHILADELPHIA (April 5, 2024)—Fox Chase Cancer Center and the Lewis Katz School of Medicine at Temple University researchers will participate in the presentation and discussion of 16 research projects at the American Association of Cancer Research (AACR) Annual Meeting 2024, which is being held in San Diego April 5-10. An asterisk (*) indicates that the author is the main presenter.

Sunday, April 7

24-A-2128-AACR: Tobacco smoke exposure, hormonal history, and estrogen metabolism in women with EGFR-mutant non-small cell lung cancer (NSCLC); Ahmad Raza*, Joseph Treat, Daniel D. Krzizike, Lisa Vanderveer, Mitchell Cheung, Carolyn Zawislak, Lisa Etkins, Eric Ross, Douglas B. Flieder, Martin J. Edelman, Margie L. Clapper, J. Nicholas Bodor; Temple Univ. Lewis Katz School of Medicine, Philadelphia, PA; Fox Chase Cancer Center, Philadelphia, PA; Session Type: Poster Session; Session Title: Epidemiology; Location: Section 32; Session Time: Sunday, April 7, 2024, 1:30 pm - 5:00 pm PDT; Presentation Number: 765; Poster Board Number: 1.

Monday, April 8

24-A-2572-AACR: Contribution of estrogen metabolites to never-smoking lung cancer; Mitchell Cheung*; Lisa A. Vanderveer, Daniel Krzizike, J. Nicholas Bodor, Joseph Treat, Joseph R. Testa, Margie L. Clapper; Fox Chase Cancer Center, Philadelphia, PA; Session Type: Poster Session; Session Title: Chemical, Environmental, and Virus-Induced Carcinogenesis; Location: Section 7; Session Time: Monday, April 8, 2024, 9:00 am - 12:30 pm PDT; Presentation Number: 1467; Poster Board Number: 5.

24-A-7536-AACR: Effects of folic acid supplementation on early stages of colitis-associated carcinogenesis; Ariane Rocha Bartolomeu*, Wen-Chi Chang, Lisa Vanderveer, Kristen N. Harvey, Mitchell Cheung, Harry S. Cooper, Margie L. Clapper; Fox Chase Cancer Center, Philadelphia, PA; Session Type: Poster Session; Session Title: Role of Diet, Nutrition, and the Microbiome Across the Cancer Continuum; Location: Section 32; Session Time: Monday, April 8, 2024, 9:00 am - 12:30 pm PDT; Presentation Number: 2170; Poster Board Number: 4.

24-A-3898-AACR: Low exposures to amphibole or serpentine asbestos in germline Bap1-mutant mice induce mesotheliomacharacterized by an immunosuppressive tumor microenvironment; Yuwaraj Kadariya*, Eleonora Sementino, Maggie Ruan, Mitchell Cheung, Andres J. Klein-Szanto, Kathy Cai, Joseph R. Testa; Fox Chase Cancer Center, Philadelphia, PA; Session Type: Poster Session; Session Title: Chemical, Environmental, and Virus-Induced Carcinogenesis; Location: Section 7; Session Time: Monday, April 8, 2024, 9:00 am - 12:30 pm PDT; Presentation Number: 1468; Poster Board Number: 6.

24-A-4241-AACR: Novel biomarkers that predict response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer; Adria Hasan*, Elena V. Demidova, Philip Czyzewicz, Karthik Devarajan, Margret B. Einarson, Donald Baldwin, Erica A. Golemis, Joshua E. Meyer, Sanjeevani Arora; Fox Chase Cancer Center, Philadelphia, PA; Session Type: Poster Session; Session Title: Predictive Biomarkers 1; Location: Section 43; Session Time: Monday, April 8, 2024, 9:00 am - 12:30 pm PDT; Presentation Number: 2506; Poster Board Number: 23.

24-A-7992-AACR: Cancer associated fibroblast dependency in a model of bladder cancer; Henkel Valentine*, Uttam Satyal, Laura Bukavina, Hassan Uddin, Yousttena Beyamin, Rhea Arya, Philip Abbosh; Fox Chase Cancer Center, Philadelphia, PA; Session Type: Poster Session Session Title: Animal Models of Cancer; Location: Section 6; Session Time: Monday, April 8, 2024, 9:00 am - 12:30 pm PDT; Presentation Number: 1436; Poster Board Number: 7.

24-A-4206-AACR: Spliceosome: A gatekeeper for necroptosis; Xinpei Jiang*, Xueying Ma, Siddharth Balachandran, Israel Cañadas; Lewis Katz School of Medicine at Temple University, Fox Chase Cancer Center, Philadelphia, PA; Session Type: Poster Session; Session Title: Combination Immunotherapies; Location: Section 43; Session Time: Monday, April 8, 2024, 1:30 pm - 5:00 pm PDT; Presentation Number: 3731; Poster Board Number: 17.

24-A-7624-AACR: Urine-based liquid biopsy test for the detection of residual bladder cancer in radical cystectomy patients; Rhea Arya*, Henkel Valentine, Uttam Satyal, Raju Chelluri, Mengmeng Li, Philip Abbosh; Fox Chase Cancer Center, Philadelphia, PA; Session Type: Poster Session; Session Title: Circulating Tumor Cells 1; Location: Section 42; Session Time: Monday, April 8, 2024, 1:30 pm - 5:00 pm PDT; Presentation Number: 3701; Poster Board Number: 13.  

Tuesday, April 9

24-A-3162-AACR: Molecular investigation of a polymorphic variant in JMJD1C that associates with chemoradiotherapy outcomes in locally advanced rectal and head and neck cancer; Adria Hasan*, Elena V. Demidova, Philip Czyzewicz, Shreya M. Shah, Karthik Devarajan, Thomas J. Galloway, Margret B. Einarson, Barbara Burtness, Erica A. Golemis, Joshua E. Meyer, Sanjeevani Arora; Fox Chase Cancer Center, Philadelphia, PA; Yale Cancer Center, Yale School of Medicine, New Haven, CT; Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Session Type: Poster Session; Session Title: Predictive Biomarkers 3; Location: Section 44; Session Time: Tuesday, April 9, 2024, 9:00 am - 12:30 pm PDT; Presentation Number: 5143; Poster Board Number: 16.

24-A-7895-AACR: Novel targets for BRAFV600E and BRAFV600ERAC1P29S drug resistant melanoma; Cristina Uribe-Alvarez*, Daniela Araiza-Olivera, Alexa Cannon, Jonathan Chernoff; Cancer Signaling and Epigenetics, Fox Chase Cancer Center, Philadelphia, PA; Session Type: Poster Session; Session Title: Reversal of Drug Resistance 1; Location: Section 30; Session Time: Tuesday, April 9, 2024, 9:00 am - 12:30 pm PDT; Presentation Number: 4747; Poster Board Number: 13.

24-A-684-AACR: Development of HSPG2 targeted glycoengineered antibody-drug conjugates; Xiaolei Li*, Swayam Prabha; Temple Univ. Lewis Katz School of Medicine, Philadelphia, PA; Session Type: Poster Session; Session Title: Novel Immunotherapies and Immune Modulation; Location: Section 42; Session Time: Tuesday, April 9, 2024, 9:00 am - 12:30 pm PDT; Presentation Number: 5090; Poster Board Number: 12.

24-A-7983-AACR: Predicting drug treatment response in African American lung cancer patients who smoke; Mia Ray, Isaiah Osei-Gyening, Kwabena Acheampong, Marisa Riebesell, Khadijah A. Mitchell*; Penn State College of Medicine, Hershey, PA; Memorial Sloan Kettering Cancer Center, New York, NY; Bristol Myers Squibb, Princeton, NJ; Lafayette College, Easton, PA; Fox Chase Cancer Center, Philadelphia, PA; Session Type: Poster Session; Session Title: Cancer Disparities 2: Survivorship Research Addressing Cancer Disparities; Location: Section 33; Session Time: Tuesday, April 9, 2024, 9:00 am - 12:30 pm PDT; Presentation Number: 4830; Poster Board Number: 19.

24-A-1375-AACR: Targeting DHX9 triggers interferon response and replication stress in small cell lung cancer; Takahiko Murayama*, Jun Nakayama, Kathy Q. Cai, Kenichi Miyata, Andrey Efimov, Yinfei Tan, Yan Zhou, Kerry S. Campbell, Yibin Yang, Siddharth Balachandran, Israel Cañadas; Fox Chase Cancer Center, Philadelphia, PA; National Cancer Center Research Institute, Tokyo; Japanese Foundation for Cancer Research, Tokyo; Session Type: Poster Session; Session Title: Immune Modulating Effects of Chemotherapy and Other Agents; Location: Section 2; Session Time: Tuesday, April 9, 2024, 1:30 pm - 5:00 pm PDT; Presentation Number: 5268; Poster Board Number: 10.

24-A-6936-AACR: How aging promotes immune mediated reactivation from metastatic melanoma dormancy; Pulkit Datt, Jhon Passamonte, Christopher Price, Daniel Zabransky, Yash Chhabra, Ashani Weeraratna, Mitchell E. Fane*; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins School of Medicine and Johns Hopkins School of Public Health, Baltimore, MD; Session Type: Poster Session; Session Title: Tumor Microenvironment of Metastasis; Location: Section 11; Session Time: Tuesday, April 9, 2024, 1:30 pm - 5:00 pm PDT; Presentation Number: 5537; Poster Board Number: 26.

Wednesday, April 10

24-A-1031-AACR: Cross-over effect” in survival curves with immune-checkpoint inhibition: Identifying ideal candidates for immunotherapy-only approaches in specific tumor histologies; Shubhank Goyal, Anish Thomas, Parth Anil Desai*; Developmental Therapeutics Branch, National Institutes of Health, Bethesda, MD; Fox Chase Cancer Center, Philadelphia, PA; Session Type: Poster Session; Session Title: Immune Checkpoint Inhibitor Therapy; Location: Section 42; Session Time: Wednesday, April 10, 2024, 9:00 am - 12:30 pm PDT; Presentation Number: 7537; Poster Board Number: 25.

24-A-1660-AACR: Crosstalk between histone and DNA methylation in the development and progression of ALK+ ALCL; Cosimo Lobello*, Shengchun Wang, Shilpa Rao, Jan Pawlicki, Nashwa Mansoor, James L. Riley, Reza Nejati, Wasik A. Mariusz; Fox Chase Cancer Center, Philadelphia, PA; University of Pennsylvania, Philadelphia, PA; Session Type: Poster Session; Session Title: Epigenetic Profiling and Technology; Location: Section 15; Session Time: Wednesday, April 10, 2024, 9:00 am - 12:30 pm PDT; Presentation Number: 7015; Poster Board Number: 15.

Fox Chase Cancer Center (Fox Chase), which includes the Institute for Cancer Research and the American Oncologic Hospital and is a part of Temple Health, is one of the leading comprehensive cancer centers in the United States. Founded in 1904 in Philadelphia as one of the nation’s first cancer hospitals, Fox Chase was also among the first institutions to be designated a National Cancer Institute Comprehensive Cancer Center in 1974. Fox Chase is also one of just 10 members of the Alliance of Dedicated Cancer Centers. Fox Chase researchers have won the highest awards in their fields, including two Nobel Prizes. Fox Chase physicians are also routinely recognized in national rankings, and the Center’s nursing program has received the Magnet recognition for excellence six consecutive times. Today, Fox Chase conducts a broad array of nationally competitive basic, translational, and clinical research, with special programs in cancer prevention, detection, survivorship, and community outreach. It is the policy of Fox Chase Cancer Center that there shall be no exclusion from, or participation in, and no one denied the benefits of, the delivery of quality medical care on the basis of race, ethnicity, religion, sexual orientation, gender, gender identity/expression, disability, age, ancestry, color, national origin, physical ability, level of education, or source of payment.

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