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Original/Peer Reviewed Articles

Durvasula RV, Gumbs AA, Panackal A, Kruglov O, Aksoy S, Merrifield RB, Richards FF, Beard CB. Prevention of insect-borne disease: an approach using transgenic symbiotic bacteria. Proc Natl Acad Sci U S A. 1997 Apr 1; 94(7): 3274-8.

Turner BC, Haffty BG, Narayanan L, Yuan J, Havre PA, Gumbs AA, Kaplan L, Burgaud JL, Carter D, Baserga R, Glazer PM.  Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res. 1997 Aug 1; 57(15): 3079-83.

Turner BC, Knisely JP, Kacinski BM, Haffty BG, Gumbs AA, Roberts KB, Frank AH, Peschel RE, Rutherford TJ, Edraki B, Kohorn EI, Chambers SK, Schwartz PE, Wilson LD.  Effective treatment of stage I uterine papillary serous carcinoma with high dose-rate vaginal apex radiation (192Ir) and chemotherapy. Int J Radiat Oncol Biol Phys. 1998 Jan 1; 40(1): 77-84.

Maher MG, Sapi E, Turner B, Gumbs AA, Perrotta PL, Carter D, Kacinski BM, Haffty BG.Prognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence. Clin Cancer Res. 1998 Aug; 4(8):1851-6.

Turner BC, Zhang J, Gumbs AA, Maher MG, Kaplan L, Carter D, Glazer PM, Hurst HC, Haffty BG, Williams T.  Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Res. 1998 Dec 1; 58(23): 5466-72.

Spector SA, Olson ET, Gumbs AA, Friess H, Buchler MW, Seymour NE. Human
insulin receptor and insulin signaling proteins in hepatic disease. J Surg Res. 1999 May 1; 83(1): 32-5.

Durvasula RV, Gumbs A, Panackal A, Kruglov O, Taneja J, Kang AS, Cordon-Rosales C, Richards FF, Whitham RG, Beard CB.Expression of a functional antibody fragment in the gut of Rhodnius prolixus via transgenic bacterial symbiont Rhodococcus rhodnii. Med Vet Entomol. 1999 May; 13(2): 115-9.

Turner BC, Harrold E, Matloff E, Smith T, Gumbs AA, Beinfield M, Ward B, Skolnick M, Glazer PM, Thomas A, Haffty BG.BRCA1/BRCA2 germline mutations in locally recurrent breast cancer patients after lumpectomy and radiation therapy: implications for breast-conserving management in patients with BRCA1/BRCA2 mutations. J Clin Oncol. 1999 Oct; 17(10): 3017-24.

Turner BC, Gumbs AA, Carbone CJ, Carter D, Glazer PM, Haffty BG. Mutant p53 protein overexpression in women with ipsilateral breast tumor recurrence following lumpectomy and radiation therapy. Cancer. 2000 Mar 1; 88(5): 1091-8.

Lehman TA, Haffty BG, Carbone CJ, Bishop LR, Gumbs AA, Krishnan S, Shields PG, Modali R, Turner BC. Elevated frequency and functional activity of a specific germ-line p53 intron mutation in familial breast cancer. Cancer Res. 2000 Feb 15; 60(4): 1062-9.

Turner BC, Gumbs AA, Carter D, Glazer PM, Haffty BG. Cyclin D1 expression and early breast cancer recurrence following lumpectomy and radiation.  Int J Radiat Oncol Biol Phys. 2000 Jul 15; 47(5): 1169-76.

Turner BC, Krajewski S, Krajewska M, Takayama S, Gumbs AA, Carter D, Rebbeck TR, Haffty BG, Reed JC. BAG-1: A Novel Biomarker Predicting Long-Term Survival in Early-Stage Breast Cancer. J Clin Oncol. 2001 Feb 15; 19(4): 992-1000.

Gumbs AA, Bassi C, Moore PS, Falconi M, Frigerio I, Baron A, Piemonti L, Modlin I, Scarpa A. Overexpression of the Sm-like proto-oncogene in primary and metastatic pancreatic endocrine tumors. Journal of the Pancreas. 2002 Jul; 3(4): 109-15.

Bassi C, Salvia R, Gumbs AA, Butturini G, Falconi M, Pederzoli P. The value of standard serum tumor markers in differentiating mucinous from serous cystic tumors of the pancreas: CEA, Ca 19-9, Ca 125, Ca 15-3. Langenbecks Arch Surg. 2002 Nov; 387(7-8): 281-5.

Gumbs AA, The Endocrine and Pancreatic Unit at the University of Verona, Italy. HPB. 2002; 4(4): 171-3.

Bassi C, Falconi M, Molinari E, Mantovani W, Butturini G, Gumbs AA, Salvia R, Pederzoli P. Duct-to-mucosa versus end-to-side pancreaticojejunostomy reconstruction after pancreaticoduodenectomy: results of a prospective randomized trial. Surgery. 2003 Nov; 134(5): 766-71

Bassi C, Butturini G, Molinari E, Mascetta G, Salvia R, Falconi M, Gumbs A, Pederzoli P. Pancreatic Fistula Rate after Pancreatic Resection.The Importance of Definitions. Dig Surg. 2004;21(1):54-9.

Gumbs AA, Shah RV, Yue JJ, Sumpio B. The Open Anterior Paramedian Retroperitoneal Approach for Spine Procedures. Arch of Surg, 2005 Apr;140(4):339-43.

Mansueto G, Cenzi D, D'Onofrio M, Petrella E, Gumbs AA, Mucelli RP. Treatment of Type II Endoleaks After Endovascular Repair of Abdominal Aortic Aneurysms: Transcaval Approach. Cardiovasc Intervent Radiol. 2005 Sep-Oct;28(5):641-5.

Gumbs AA, AJ Duffy, R Chandwani, and RL Bell. Jejunojejunal Anastomotic Obstruction Following Laparoscopic Roux-Y Gastric Bypass Due to Non-absorbable Suture: A Report of Seven Cases. Obesity Surgery, January 2006.

Gumbs AA, Duffy AJ, and Bell RL. Management of Gastrogastric fistula after laparoscopic Roux-Y gastric bypass. Surg Obes Relat Dis. 2006 Mar-Apr;2(2):117-21.

Gumbs AA, Duffy AJ, and Bell RL. Incidence and Management of Marginal Ulceration after Laparoscopic Roux-Y Gastric Bypass. Surg Obes Relat Dis. 2006 Jul-Aug; 2(4):460-3.

Gumbs AA, Hanan S, Yue JJ and Sumpio B. Revision Open Anterior Approaches for Spine Procedures. Spine J. 2007 May-June; 7(3): 280-5.

Gumbs AA, Hogle NJ and Fowler D. Evaluation of Resident Laparoscopic Performance Using Global Operative Assessment of Laparoscopic Skills. JACS 2007 Feb; 204(2):308-13.

Rau BM, Kemppainen EA, Gumbs AA, Buchler MW, Wegscheider K, Bassi C, Puolakkainen PA, Beger HG. Early Assessment of Pancreatic Infections and Overall Prognosis in Severe Acute Pancreatitis (PCT): A Prospective International Multicenter Study. Ann Surg. 2007 May; 245(5):745-754.

Mansueto G, Cenzi D, Scuro A, Gottin L, Griso A, Gumbs AA, Mucelli PZ. Treatment of type II endoleak with a transcatheter transcaval approach: Results at 1-year follow-up.  J. Vasc. Surg. 2007 ; 45(6): 1120-1127.

Gumbs AA, Bloom ND, Bitan FD and Hanan SH. Open Anterior Approaches for Lumbar Spine Procedures. Am J Surg. 2007 Jul; 194(1):98-102.

Gagner M, Gumbs AA, Milone L, Yung E, Goldenberg L and Pomp A. Laparoscopic Sleeve Gastrectomy in the Super-obese (BMI > 60 kg/m2). Surg Today. 2008;38(5):399-403.

Gumbs AA and Gumbs MA, Why Doctors Without Borders Has Particular Relevance to Today’s Graduating Surgeons. J Surg Ed. 2007 Sep/Oct; 64(5).

Mansueto G, Cenzi D, Scuro A, Gottin L, Griso A, Gumbs AA, Mucelli PZ. Endovascular Treatment of Arterial Bleeding in Patients With Pancreatitis. Pancreatology, 2007. Pancreatology. 2007;7(4):360-9.

Gumbs AA, Grès P, Madureira F and Gayet B. Laparoscopic vs. Open Resection of Intraductal Pancreatic Mucinous Neoplasms. J. Gastrointestinal Surg. 2007 Oct. 2.

Gumbs AA, Crovari F, Vidal C, Henri P and Gayet B. Modified Robotic Lightweight Endoscope (ViKY) Validation in Vivo in a Porcine Model. Surg. Innov. December 2007.

Gumbs AA. The Minimally Invasive Hepato-Pancreato-Biliary Fellowship at the Institut Mutualiste Montsouris (IMM), Paris, France. HPB. The Medical and Surgical Department of Digestive Diseases and Minimally Invasive HPB Fellowship at IMM. HPB 2007;9(6):470-1.

Gumbs AA, Grès P, Madureira F and Gayet B. Laparoscopic vs. Open Resection of Pancreatic Endocrine Neoplasms: Single-Institution’s Experience Over 14-Years. Langenbecks Arch Surg. 2008 May;393(3):391-5.

Gagner M, Milone L, Nelson T, Broseus A, Elliot Y and Gumbs A
Causes of early mortality after Laparoscopic Adjustable Gastric Banding. J.A.C.S. Apr; 2006(4):664-9.

Gumbs AA, Gayet B and Gagner M. Laparoscopic Liver Resection: When to Use the Laparoscopic Stapler Device, 2008. HPB; 10 (4):296-303.

Gumbs AA, Gumbs MA, Gleit Z and Hopkins MA. How International Electives Could Save General Surgery, 2008. Am J Surg. IN PRESS

 

Surgical Oncology
Director of Minimally Invasive Hepato-Pancreatic and Biliary (HPB) Surgery
Surgical Associate Director of MIS/Endoscopic Skills Fusion Lab
Associate Member, Department of Surgical Oncology

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gastrointestinal cancer treatment team.

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Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111-2497

Clinical Expertise:

Laparoscopy, Open and Minimally Invasive Hepato-Pancreatic and Biliary (HPB) Surgery, Scarless Surgery: Single Incision Laparoscopic Surgery, Laparo-Endoscopic Single Incision (LESS) Surgery and Natural Orifice Transluminal endoscopic Surgery (NOTES).

Education:

MD, Yale University School of Medicine, 1998

Residency:

Chief General Surgery Resident, Yale-New Haven Hospital, New Haven, CT, 2005;
Categorical General Surgery Resident, Yale-New Haven Hospital, New Haven, CT, 1999,2000 and 2003,2004

Fellowships:

Minimally Invasive HPB Fellow,
Institut Mutualiste Montsouris,
Université René Descartes Paris V, France, 2007;
Minimal Access Surgery Fellow,
New York-Presbyterian Hospital,
The University Hospital of Columbia and Cornell, New York, NY, 2006;
Fellowship in Pancreatic Surgery, University of Verona, Italy, 2001,2002

Certifications:

American Board of Surgery
Fundamentals of Laparoscopic Surgery

Professional Societies:

Associate Member,
American College of Surgeons;
Society of American Gastrointestinal and Endoscopic Surgeons;
American Hepato-Pancreato-Biliary Association;
New York Surgical Society;
International Hepato-Pancreato-Biliary Association;
Physicians for Human Rights;
Médecins Sans Frontieres

Publications:

Recent Publications

Research Interests:

Minimally Invasive Surgery (MIS), single incision laparoscopic surgery, natural orifice transluminal endoscopic surgery (NOTES), robotics in surgery, the contribution of obesity to carcinogenesis