Hossein Borghaei, DO
Fox Chase Cancer Center
333 Cottman Ave
Philadelphia, PA 19111-2497
Video: Hossein Borghaei, DO
Chief, Thoracic Oncology
Director, Lung Cancer Risk Assessment
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American Board of Internal Medicine;
National Board of Osteopathic Medical Examiners;
After completing my fellowship at Fox Chase, I joined the medical staff in 2004. I have a special interest in lung cancers. I believe in offering my patients the newest therapies available, which include antibodies and other immune-based therapies.
My laboratory research is focused on the production of monoclonal antibodies against novel targets in tumor blood vessels. These antibodies have the potential to be used in the treatment of several types of cancer. In addition, my other research interest is to learn how the body's immune system plays a role in the fight against cancer.
Philadelphia College of Osteopathic Medicine, 1996
MS in Microbiology and Immunology, Temple Medical School, Philadelphia, Pennsylvania
Graduate Hospital, Philadelphia, Pa.
Hematology-Oncology, Fox Chase Cancer Center, Chief Fellow
Monoclonal Antibody; Targeted Therapy; Immunotherapy Cancer Vaccine
My laboratory is interested in immunotherapy for cancer, with particular emphasis on the clinical development and application of monoclonal antibodies. Recent work from my group includes a Phase I trial of naptumomab estafenatox, a recombinant fusion protein consisting of a mutated variant of the superantigen staphylococcal enterotoxin E (SEA/E-120) linked to the antigen binding moiety of a monoclonal antibody recognizing the tumor-associated antigen 5T. In addition to developing new monoclonal antibodies, I am conducting clinical trials exploring the immunological responses that occur as a result of cetuximab therapy-associated antibody-dependent cellular cytotoxicity (ADCC)ADCC, with the goal of augmenting these immune responses to achieve improved efficacy of antibody therapy. In addition, I am involved in a number of clinical trials with various other monoclonal antibodies such as cetuximab. My latest lung cancer trial explores the relationship between EGFR and Aurora Kinase in lung cancer.
- Binyamin L, Alpaugh RK, Campbell KS, Borghaei H, Weiner LM. Rituximab-mediated ADCC is augmented by concomitant interference with inhibitory self-recognition by human NK cells. Blood. 2005;106:690A-691A.
- Borghaei H, Alpaugh K, Hedlund G, Forsberg G, Langer C, Rogatko A, Hawkins R, Dueland S, Lassen U, Cohen RB. Phase I dose escalation, pharmacokinetic and pharmacodynamic study of naptumomab estafenatox alone in patients with advanced cancer and with docetaxel in patients with advanced non-small-cell lung cancer. J Clin Oncol. 2009;27:4116-23.
- Borghaei H, Alpaugh RK, Bernardo P, Palazzo IE, Dutcher JP, Venkatraj U, Wood WC, Goldstein L, Weiner LM. Induction of adaptive Anti-HER2/neu immune responses in a Phase 1B/2 trial of 2B1 bispecific murine monoclonal antibody in metastatic breast cancer (E3194): A Trial Coordinated by the Eastern Cooperative Oncology Group. J Immunother. 2007;30:455-467.
- Borghaei H, Binyamin L, Astsaturov I, Weiner AM. Antibody therapy of cancer. In: Molecular Targeting in Oncology. (Kaufman, H.L., Wadler, S., Antman, K., eds.), pp. 371-412. Humana Press, Totowa, NJ, 2008. Book Chapter
- Borghaei H, Langer CJ, Millenson M, Ruth KJ, Litwin S, Tuttle H, Seldomridge JS, Rovito M, Mintzer D, Cohen R, Treat J. Phase II study of paclitaxel, carboplatin, and cetuximab as first line treatment, for patients with advanced non-small cell lung cancer (NSCLC): results of OPN-017. J Thorac Oncol. 2008;3:1286-1292.
- Borghaei H, Mehra, R., Simon, G. Current issues in adjuvant chemotherapy for resected, stage IB non-small-cell lung cancer. Fut Oncol. 2009;5:19-22.
- Borghaei H, Robinson MK, Weiner LM. Monoclonal antibody therapy of cancer. In: Immunotherapy of Cancer (Disis, M.L., ed.), pp. 487-502. Humana Press, Totowa, NJ, 2006.
- Borghaei H Smith MR, Campbell KS. Immunotherapy of cancer. Eu J Pharmacol. 2009;625:41-54.
- Carcereny E, Moran T, Felip E, Borghaei H, Fitzgerald T, Clark J, Guan S, Hsu K, Beckman R, Yan L, Rosell R, Johnson DH. An open label, randomized Phase I/IIA Trial evaluating MK-0646, an anti-IGF-1R monoclonal antibody (MoAB), in combination with erlotinib for patients with recurrent non-small cell lung cancer (NSCLC). 13th World Conference on Lung Cancer, San Francisco, July, 2009. Conference
- Faller BA, Robu VG, Borghaei H. Therapy-related acute myelogenous leukemia with an 11q23/MLL translocation following adjuvant cisplatin and vinorelbine for non-small-cell lung cancer. Clin Lung Cancer. 2009;10:438-440.
- Huang C, Treat J, Borghaei H, Millenson MM, Mintzer DM, Cohen RB, Staddon AP, Seldomridge J, Langer CJ. Promising survival in patients with recurrent non small cell lung cancer (NSCLC) treated with docetaxel and gemcitabine in combination as second line therapy. J Thorac Oncol. 2008;3:1032-1038. Not supported by NIH funding
- Kurzrock R, Fayad L, Voorhees P, Furman RR, Lonial S, Borghaei H, Jagannath S, Sokol L, Cornfeld M, Qi M, Jiao T, Herring J, Qin X, van Rhee F. A Phase I study of CNTO 328, an anti-interelukin-6 monoclonal antibody in patients with A-cell non-hodgkin's lymphoma, multiple myeloma, or Castleman's disease, pp. 371-372, 2008. Book Chapter
- Narra K, Borghaei H, Al-Saleem T, Hoeglund M, Smith MR. Pure red cell aplasia in B-cell lymphoproliferative disorder treated with rituximab: Report of two cases and review of the literature. Leuk. Res. 2005;30:109-114.
- Robinson MK, Borghaei H, Adams GP, Weiner LM. Pharmacology of cancer biotherapeutics – monoclonal antibodies. In: Cancer: Principles and Practice of Oncology (DeVita, V.T., Hellman, S., Rosenberg, S.A., eds.), pp. 537-547. Lippincott Williams & Wilkins, 2008. Book Chapter
- Shafer D, Borghaei H, Millenson M, Nicolaou N, Al-Saleem TI, Leasure NC, Padavic K, Smith MR, Schilder RJ. Vinblastine, mitoxantrone and prednisone (MVP) followed by involved field radiotherapy (IF-XRT) for early clinical stage Hodgkins's lymphoma: Long term follow-up. Blood. 2005;106:751A-751A.
- Shafer, D., Smith, M.R., Litwin, S., Li, T., Borghaei H, Al-Saleem, T.I. Peripheral blood CD3(+)CD4(+) and CD3(-)CD56(+) cell counts and circulating lymphoma cells are significant predictors of overall survival in newly diagnosed follicular lymphoma. Blood. 2007;110:767A-768A.
- Shafer D, Wu H, Al-Saleem T, Reddy K, Borghaei H, Lessin S, Smith M. Cutaneous precursor B-cell lymphoblastic lymphoma in 2 adult patients: clinicopathologic and molecular cytogenetic studies with a review of the literature. Arch Dermatol. 2008 Sep;144(9):1155-62. Accepted prior to April 7, 2008
- Smith M, Borghaei H. Comment on Phase II study of weekly low-dose paclitaxel for relapsed and refractory non-Hodgkin's lymphoma: A Wisconsin Oncology Network Study, by Kahl et al., Cancer Invest. 2005;23:13-18.
- Smith MR, Borghaei H. Comment on phase II study of weekly low-dose paclitaxel for relapsed and refractory non-Hodgkin's lymphoma: A Wisconsin Oncology Network Study," by Kahl et al. Cancer Invest. 200523:572.
- Weiner LM, Borghaei H. Targeted therapies in solid tumors: Monoclonal antibodies and small molecules. Hum Antibodies. 2006;15:103-111.