David S. Weinberg, MD, MSc
Fox Chase Cancer Center
333 Cottman Ave
Philadelphia, PA 19111
Video: Dr. Weinberg, Chief of Gastroenterology
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Chair, Internal Medicine
Chief, Gastroenterology Section
Audrey Weg Schaus and Geoffrey Alan Weg Chair in Medical Science
Member: Keystone Program in Personalized Risk and Prevention
Cancer Risk Assessment and Prevention Research Program
Meet other members of the gastrointestinal cancer treatment team.
American Board of Internal Medicine;
I joined the staff at Fox Chase Cancer Center in 2001 as director of gastroenterology. While my gastroenterology colleagues and I see many patients with cancers of all types, we are very happy to care for the gastrointestinal needs of patients without cancer as well.
I have a special interest in cancer prevention, especially for patients who are at average risk for gastrointestinal cancers. The current methods of gastrointestinal cancer prevention tools, like colonoscopy, are very effective. However, it is very likely that the next generation of screening techniques will be substantially better. Finding new ways to increase participation in screening programs and to use molecular or genetic markers to provide more accurate estimates of risk are particular interests of mine. Hopefully, finding such markers will allow for better targeting of screening and other risk reduction strategies now and in the future.
Colorectal cancer prevention in average risk populations
Colorectal cancer (CRC) is the second leading cause of cancer death in the U.S. Periodic screening can reduce the incidence and mortality from this disease. Unfortunately, screening is underutilized. Less than 50% of the U.S. population has been appropriately screened according to standard guidelines. The poor acceptance rate is particularly disappointing since no other common human malignancy represents such an appropriate target for cancer prevention. Effective strategies to increase screening rates, targeted towards patients or providers, have proven elusive. The major goals of our research program are the development of novel CRC risk stratification tools in average risk populations to facilitate more appropriate use of screening tests as well as investigating new methods to increase screening utilization. Several ongoing, large multi-center trials are underway that investigate new clinical platforms for CRC screening, the impact of gene-environment interaction on CRC risk stratification and the utility of patient specific informatiosn tailoring to increase CRC screening use.
MSc, Cancer Epidemiology, University of Pennsylvania, Philadelphia, PA, 1997;
MD, Cornell University Medical College, NY, NY, 1989
Internal Medicine, Beth Israel Hospital, Boston, MA
Gastroenterology, University of Pennsylvania, Philadelphia, PA;
Clinical Epidemiology, University of Pennsylvania, Philadelphia, PA
American Association for Cancer Research;
American Gastroenterological Association, Fellow;
The American College of Gastroenterology;
National Institutes of Health, Member, Clinical Oncology Emphasis Panel
Personalized Risk and Prevention;
Cancer Risk Assessment and Prevention Research
- Waldman SA, Hyslop T, Schulz S, Barkun A, Nielsen K, Haaf J, Bonaccorso C, Li Y and Weinberg DS. Association of GUCY2C expression in lymph nodes with time to recurrence and disease free survival in pN0 colorectal cancer. JAMA 2009; 301:745-52.
- Jimbo M, Myers RE, Meyer B, Hyslop T, Cocroft J, Turner BJ, Weinberg DS. Reasons patients with a positive fecal occult blood test result do not undergo complete diagnostic evaluation. Ann Fam Med. 2009;7:11-6.
- Weinberg DS: In The Clinic: Colorectal Cancer Screening. Ann Intern Med 2008; 148: ITC2-1—2-16.
- Manne SL, Chung DC, Weinberg DS, Vig HS, Catts Z, Cabral MK, Shannon K, Meropol NJ: Knowledge and attitudes about microsatellite instability testing among individuals diagnosed with colorectal cancer. Cancer Epidemiol Biomarkers Prev 2007;16:2110-2117.
- Myers R, Weinberg DS, Manne S, Sifri R, Cocroft J, Kash K and Wilfond B: Gene environmental risk assessment for colorectal cancer risk in primary care practice settings: a pilot study. Genetics in Medicine 2007; 9:378-384.