Research at Fox Chase »Research Programs »Research Areas

Members of the Genome Stability Working Group share common interests in understanding the molecular and biochemical mechanisms that specify the stability of the genome. A variety of model systems (Human, mouse, Xenopus, Drosophila, and retroviruses) are used to study process that include DNA replication, repair, recombination, chromatin organization, chromosome segregation and checkpoint controls. Our group is interested in achieving a global view of the protein networks that link all of these processes and to use this information to enhance cancer diagnosis and treatment. Members of this research program interact with members from other groups that are interested in cancer, developmental therapeutics and cell and developmental biology.

Program Leader

• Tim J Yen, PhD

Program Members

• Peter D Adams, PhD
• Gregory H Enders, MD, PhD
• Yoshihiro Matsumoto, PhD
• Hong Yan, PhD

Participating Members

• Alfonso Bellacosa, MD, PhD
• Anna Marie Skalka, PhD
• Alexei Tulin, PhD