Table of Services

Irradiation Facility

Function

The Irradiation Facility enables Fox Chase investigators to accurately expose chemical and biological specimens to ionizing gamma rays. The gamma irradiators are used to irradiate molecules in solution, cell cultures, rodent tumors and/or rodents for studies of radiobiologic mechanisms, to suppress immune responses in experimental animals, as well as to sterilize various cell, vaccine and drug preparations. The Facility staff is available to Fox Chase investigators for planning radiation experiments, assisting those who are infrequent users of irradiators, training individuals to be qualified users of specific equipment in accordance with PA-DEP and other safety regulations and making dosimetry measurements.

Description

The Irradiation Facility operates two different irradiators sited at two different locations that are optimal for their experimental usage. One self-shielded irradiator is used mainly to suppress the immune response of small animals by whole body irradiation. The other irradiator is a panoramic irradiator that can be operated to produce either vertical or horizontal beams of gamma rays at high intensity within a shielded experimental room. Various dose rates can be achieved by the use of attenuation and positioning experiments at various distances from the source.