Table of Services

Laboratory Animal Facility Publications


  • Altomare, D.A., Zhang, L., Deng, J., Di Cristofano, A., Klein-Szanto, A.J., Kumar, R., Testa, J.R. GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt. Clin. Cancer Res. 16:486-496, 2010. PMCID: PMC2807995
  • Bassi, D.E., Zhang, J., Cenna, J., Litwin, S., Cukierman, E., Klein-Szanto, A.J. Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis. Neoplasia 12:516-526, 2010. PMCID: PMC2907578
  • Connolly, D.C., Hensley H.H. Xenograft and transgenic mouse models of epithelial ovarian cancer and non-Invasive imaging modalities to monitor ovarian tumor growth in situ: applications in evaluating novel therapeutic agents. Curr. Protoc. Pharmacol. 45:14.12.1-14.12.36, 2010. PMCID: PMC2904083
  • Fu, J., Jin, F., Zhang, J., Fong, K., Bassi, D., Lopez De Cicco, R., Ramaraju, D., Braunewell, K-H., Conti, C. , Benavides, F., Klein-Szanto A.J. VILIP-1 expression in vivo results in decreased mouse skin keratinocyte proliferation and tumor development. PLoS One 5:e10196, 2010. PMCID: PMC2855367
  • Singh, L.R., Gupta, S., Honig, N.H., Kraus, J.P., Kruger, W.D. Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70. PLoS Genet. 6:e1000807, 2010. PMCID: PMC2795852
  • Tan, Y., You, H., Wu, C., Altomare, D.A., Testa, J.R. Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J. Biol. Chem. 285:6377-6389, 2010. PMCID: PMC2825433
  • Xu, R.H., Remakus, S., Ma, X., Roscoe, F., Sigal, L.J. Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response. PLoS Pathog. 6:e1000768, 2010. PMCID: PMC2820535


  • Altomare, D.A., Menges, C.W., Pei, J., Zhang, L., Skele-Stump, K.L., Carbone, M., Kane, A.B., Testa, J.R. Activated TNFa/NfB signaling via down regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice. Proc. Natl. Acad. Sci. U.S.A. 106:3420-3425, 2009. PMCID: PMC2644256
  • Gupta, S., Kuhnisch, J., Mustafa, A., Lhotak, S., Schlachterman, A., Slifker, M.J., Klein-Szanto, A., High, K.A., Austin, R.C., Kruger, W.D. Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia. FASEB J. 23:883-893, 2009. PMCID: PMC2653989
  • Izumchenko, E., Singh, M.K., Plotnikova, O.V., Tikhmyanova, N., Little, J.L., Serebriiskii, I.G., Seo, S., Kurokawa, M., Egleston, B.L., Klein-Szanto, A., Pugacheva, E.N., Hardy, R.R., Wolfson, M., Connolly, D.C., Golemis, E.A. NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 69:7198-7206, 2009. PMCID: PMC2758619
  • Boquoi, A., Chen, T., Enders, G.H. Chemoprevention of colon tumorigenesis in a mouse model by the CDK inhibitor SNS-032. Cancer Prev. Res. 2:800-806, 2009. PMCID: PMC2819381
  • Boquoi, A., Jover, R., Chen, T., Pennings, M., Enders, G.H. Transgenic expression of VEGF in intestinal epithelium drives mesenchymal cell interactions and epithelial neoplasia. Gastroenterology 136:596-606, 2009. PMCID: PMC2824597
  • Hensley, H.H., Merkel, C.E., Chang, W.C., Devarajan, K., Cooper, H.S., Clapper, M.L. Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse. Gastrointest. Endosc. 69:742-749, 2009. PMCID: PMC2821747
  • Kadariya, Y., Yin, B., Tang, B., Shinton, S.A., Quinlivan, E.P., Hua, X., Klein-Szanto, A., Al-Saleem, T.I., Bassing, C.H., Hardy, R.R., Kruger, W.D. Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma. Cancer Res. 69:5961-5969, 2009. PMCID: PMC2757012
  • Lauritsen, J.P.H., Wong, G.W., Lee, S.Y., Lefebvre, J.M., Ciofani, M., Rhodes, M., Kappes, D.J., Zúñiga-Pflücker, J.C., Wiest, D.L. Marked induction of the helix-loop-helix protein Id3 promotes the gd T cell fate and renders their functional maturation Notch-independent. Immunity 31:565-575, 2009.  PMCID: PMC2768560
  • Leu, J.I., Pimkina, J., Frank, A., Murphy, M.E., George, D.L.  A small molecule inhibitor of inducible heat shock protein 70.  Mol. Cell. 36:15-27, 2009. PMCID: PMC2771108
  • Ma, X., Serna, A., Xu, R.H., Sigal, L.J. The amino acid sequences flanking an antigenic determinant can strongly affect MHC class I cross-presentation without altering direct presentation. J. Immunol. 182:4601-4607, 2009. PMCID: PMC2756161
  • Markushin, Y., Melikechi, N., Marcano, O.A., Rock S., Henderson, E., Connolly, D. LIBS-based multi-element coded assay for ovarian cancer application. Proc. SPIE 7190:719015, 2009. Not Supported by NIH funding
  • Pimkina, J., Humbey, O., Zilfou, J.T., Jarnik, M., Murphy M.E.  ARF induces autophagy by virtue of interaction with and inhibition of Bcl-xl.  J Biol Chem 284:2803-2810, 2009. PMCID: PMC2631963
  • Pimkina, J., Murphy M.E.  ARF, autophagy and tumor suppression.  Autophagy 5:1-3, 2009. PMCID: PMC2667648
  • Quinn, B.A., Brake, T., Hua, X., Baxter-Jones, K., Ellenson, L.H., Litwin, S., Connolly, D.C. Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53. PLoS One 4:e8404, 2009. PMCID: PMC2796165
  • Timakhov, R.A., Tan, Y., Rao, M., Liu, Z., Altomare, D.A., Pei, J., Xu, J., Wiest, D.L., Favorova, O.O., Knepper, J.E., Testa, J.R. Recurrent chromosomal rearrangements implicate oncogenes that contribute to T-cell lymphomagenesis in Akt2 transgenic mice. Genes Chromosomes Cancer 48:786-794, 2009. PMCID: PMC2739734
  • Xu, M., Sharma, A., Wiest, D.L., Sen, J.M. Pre-TCR induced b-Catenin facilitates traversal through b-Selection by regulating expression of Egr Genes. J. Immunol. 182:751-758, 2009. PMCID: PMC2657338
  • Xu, M., Sharma, A., Houssain, M.Z., Wiest, D.L., Sen, J.M. Sustained expression of pre-TCR-induced b-catenin in post b-selection thymocytes blocks T cell development. J. Immunol. 182:759-765, 2009. PMCID: PMC2701226


  • Fang, M., Lanier, L.L., Sigal, L.J. A role for NKG2D in NK cell-mediated resistance to poxvirus disease. PLoS Pathog 4:e30, 2008. PMCID: PMC2233669
  • Humbey, O., Pimkina, J., Zilfou, J.T., Jarnik, M., Dominguez-Brauer, C., Burgess, D.J., Eischen, C.M., Murphy, M.E. The ARF tumor suppressor can promote the progression of some tumors. Cancer Res. 68:9608-9613, 2008. PMCID: PMC2637809
  • Clapper, M.L., Gary, M.A., Coudry, R.A., Litwin, S., Chang, W.C., Devarajan, K., Lubet, R.A., Cooper, H.S. 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis. Inflamm. Bowel Dis. 14:1341-1347, 2008. Accepted prior to April 7, 2008
  • Gupta, S., Wang, L., Hua, X., Krijt, J., Kozich, V., Kruger, W.D. Cystathionine B-synthase p.S466L mutation causes hyperhomocysteinemia in mice. Hum. Mutat. 29:1048-1054, 2008. PMCID: PMC2630375
  • Gururajan, M., Simmons, A., Dasu, T., Spear, B.T., Calulot, C., Robertson, D., Wiest, D.L., Monroe, J., Bondada, S. Early growth response genes regulate B cell development, proliferation and immune response. J. Immunol. 181:4590-4602, 2008. PMCID: PMC2592513
  • Lauritsen, J.P.H., Kurella, S., Lee, S.Y., Lefebvre, J.M., Rhodes, M., Gridley, T., Alberola-Ila, J., Wiest, D.L. Egr2 is required for Bcl-2 induction during positive selection. J. Immunol. 181:7778-7785, 2008. PMCID: PMC2587029
  • MacFarlane, A.W., IV, Yamazaki, T., Fang, M., Sigal, L.J., Kurosaki, T., Campbell, K.S. Enhanced NK cell development and function in BCAP-deficient mice. Blood 112:131-140, 2008. PMCID: PMC2435684
  • Mustafa, A., Kruger, W.D. Suppression of tumor formation by a cyclooxygenase-2 inhibitor and a peroxisome proliferator-activiated receptor agonist in an in vivo mouse model of spontaneous breast cancer. Clin. Cancer Res. 14:4935-4942, 2008. PMCID: PMC2587271
  • Robinson, M.K., Hodge, K.M., Horak, E., Sundberg, A.L., Russeva, M., Shaller, C.C., Simmon, H.H., von Mehren, M., Shchaveleva, I., Marks, J.D., Adams, G.P. Targeting ErbB2 and ErbB3 with a bispecific-single chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro. Br. J. Cancer 99:1415-1425, 2008. PMCID: PMC2576487
  • Robinson, M.K., Shaller, C., Garmestani, K., Plascjak, P.S., Hodge, K.M., Yuan, Q.A., Marks, J.D., Waldmann, T.A., Brechbiel, M.W., Adams, G.P. Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the a-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies. Clin. Cancer Res. 14:875-882, 2008. PMCID: PMC2643368
  • Tan, Y., Timakhov, R.A., Rao, M., Altomare, D.A., Liu, Z., Gao, Q., Di Cristofano, A., Wiest, D.L., Knepper, J.E., Testa, J.R. A novel recurrent chromosomal inversion implicates the homeobox bigene pair Dlx5/Dlx6 in T-cell lymphomas from Lck-Akt2 transgenic mice. Cancer Res. 68:1296-1302, 2008. Accepted prior to April 7, 2008
  • Xu, R.H., Cohen, M., Tang, Y., Lazear, E., Whitbeck, J.C., Eisenberg, R.J., Cohen, G.H., Sigal, L.J. The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination. J. Exp. Med. 205:981-992, 2008. PMCID: PMC2292233


  • Anderson, S.J., Lauritsen, J.P.H., Hartman, M., DiGeorge-Foushee, A.M., Gerhardt, B., Lefebvre, J.M., Oravecz, T., Wiest, D.L. Defect in ribosomal protein L22 selectively impars ab T cell development by activation of a p53-dependent checkpoint. Immunity 26:759-772, 2007. Selected for preview by Immunity.
  • Chang, W-C.L., Coudry, R.A., Clapper, M.L., Zhang, X., Williams, K., Spittle, C.S., Li, T., Cooper, H.S. Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium. Carcinogenesis 28:2375-2381, 2007.
  • Brewer, C., Yeager, N., Di Cristofano, A. Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT. Cancer Res. 67:8002-8006, 2007.
  • Carter, J.H., Lefebvre, J.M., Wiest, D.L., Tourtellotte, W.G. Redundant role of early growth response (Egr) transcriptional regulators in thymocyte differentiation and survival. J. Immunol. 178:6796-6805, 2007.
  • Henry, L.R., Lee, H.O., Lee, J.S., Klein-Szanto, A., Watts, P., Ross, E.A., Chen, W.T., Cheng, J.D. Clinical implications of fibroblast activiation protein (FAP) in patients with colon cancer. Clin. Cancer Res. 13:1736-1741, 2007.
  • Kiefer, K., Oshinsky, J., Kim, J., Nakajima, P.B., Bosma, G.C., Bosma, M.J. The catalytic subunit of DNA protein kinase (DNA-Pkcs) is not required for Ig class switch recombination. Proc. Natl. Acad. Sci. U.S.A. 104:2843-2848, 2007.
  • Koltsova, E.K., Miyazaki, T., Clipstone, N., Wiest, D.L. Egr1 and NFATc1 act in concert to promote thymocyte development beyond the b-selection checkpoint. J. Immunol. 179:4694-4704, 2007.
  • Mabuchi, S., Altomare, D.A., Connolly, D.C., Klein-Szanto, A., Litwin, S., Hoelzle, M.K, Hensley, H.H., Hamilton, T.C., Testa, J.R. RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer. Cancer Res. 67:2408-2413, 2007. Priority Report
  • Makhortova, N., Askovich, P., Patterson, C.E., Gechman, L.A., Gerard, N.P., Rall, G.F. Neurokinin-1 enables measles virus trans-synaptic spread in neurons. Virology 362:235-244, 2007.
  • Rose, R.W., Skipworth, J.D., Nicolas, E., Rall, G.F. Distinct STAT activation and transcriptional response in interferon-gamma stimulated primary CNS neurons. J. Neuroimunol. 192:145-156, 2007.
  • Xu, R.H., Fang, M., Klein-Szanto, A., Sigal, L.J. Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection. Proc. Natl. Acad. Sci. U.S.A. 104:10992-10997, 2007.
  • Yeager, N., Klein-Szanto, A., Kimura, S., Di Cristofano, A. Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. Cancer Res. 67:959-966, 2007.


  • Liu, S.-T., Rattner, J.B., Jablonski, S.A., Yen, T.J. Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells. J. Cell Biol. 175:41-53, 2006.
  • Toczylowski, T., Yan, H. Mechanistic analysis of a DNA end processing pathway mediated by the Xenopus Werner Syndrome Protein. J. Biol. Chem. 281:33198-33205, 2006.
  • Bort, R., Signore, M., Tremblay, K.D., Martinez Barbera, J.P., Zaret, K.S. Hex homebox gene controls the transition of the endoderm to apseudostratified, cell emergent epithelium for liver bud development. Dev. Biol. 290:44-56, 2006.
  • Bosma, G.C., Oshinsky, J., Kiefer, K., Nakajima, P.B., Charan, D., Congelton, C., Radic, M., Bosma, M.J. Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody. J. Immunol. 176:889-898, 2006.
  • Chen, X., Wang, L., Fazlieva, R., Kruger, W.D. Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response. Hum. Mutat. 27:474-482, 2006.
  • Jacquemin, P., Yoshitomi, H., Kashima, Y., Rousseau, G.G., Lemaigre, F.P., Zaret, K.S. An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Dev. Biol. 290:189-199, 2006.
  • Lian, Z., De Luca, P., Di Cristofano, A. Gene expression analysis reveals a signature of estrogen receptor activation upon loss of Pten in a mouse model of endometrial cancer. J. Cell. Physiol. 208:255-266, 2006.
  • Smith, M.R., Joshi, I., Jin, F., Al-Saleem, T. Murine model for mantle cell lymphoma. Leukemia 20:891-893, 2006.
  • Vilgelm, A., Lian, Z., Wang, H., Beauparlant, S.L., Klein-Szanto, A., Ellenson, L.H., Di Cristofano, A. Akt-mediated phosphorylation and activation of ERA is required for endometrial neoplastic transformation in Pten+/- mice. Cancer Res. 66:3375-3380, 2006.
  • Yang, D.H., Fazili, Z., Smith, E.R., Cai, K.Q., Klein-Szanto, A., Cohen, C., Horowitz, I.R., Xu, X.X. Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53 null background. Am. J. Pathol. 169:258-267, 2006.
  • Yoon, A., Peng, G., Brandenburger, Y., Zollo, O., Xu, W., Rego, E., Ruggero, D. Impairments in IRES-mediated translational control underlie X-linked dyskeratosis congenita. Science 312:902-906, 2006.