Two-hybrid system application references

- Note: this list was scanned from the Clontech booklet devoted to the
two-hybrid system; it was compiled in Oct. 1995. Some corrections were
made, and some references were added.
- Find
the abstracts in MEDLINE
- Some details of the two-hybrid system usage can be found in the Table
2 (NOT a comprehensive study)
- Some data concerning false positives
are available
-
Abovich,
N., Liao, X. C., & Rosbash, M. (1994) The yeast MUD2 protein: an interaction
with PRPl 1 defines a bridge between commitment complexes and U2 snRNP
addition. Genes & Dev. 8:843-854.
-
Aelst,
L.V., Barr, M., Marcus, S., Polverino, A. & Wigler, M. (1993) Complex
formation between RAS and RAF and other protein kinases. Proc. Natl. Acad.
Sci. USA 90:6213-6217.
-
Amrein,
H. Hedley, M. L. & Maniatis T. (1994) The role of specific protein-RNA
and protein-protein interactions in positive and negative control of pre-mRNA
splicing by Transformer 2. Cell 76:735-746.
-
Ayer,
D. E., Lawrence, Q. A., & Eisenrnan, R. N. (1995) Mad-Max transcriptional
repression is mediated by temary complex formation with mammalian homologs
of yeast repressor Sin3. Cell 80:767-776.
-
Bartel, P. L., Chien, C.-T., Sternglanz, R., & Fields, S. (1993a)
Using the two-hybrid system to detect protein-protein interactions. In
Cellular Interactions in Development: A Practical Approach., D.A. Hartley,
ed., Oxford University Press, Oxford; pp 1.
-
Bartel, P. L, Chien, C.-T., Sternglanz, R., & Fields, S. (1993b)
Elimination of false positives that arise in using the two-hybrid system.
BioTechniques 14:920-924.
-
Bendixen, C. Gangloff, S., & Rothstein, R. (1994) A yeast mating-selection
scheme for detection of protein-protein interactions. Nucleic Acids Res.
22:1778-1779.
-
Benichou, S., Bomsel, M., Bodeus, M., Durand, H., Doute, M. Letourneur,
F., Camonis, J., & Benarous, R. (1994) Physical interaction of the
HIV-l Nef protein with b-COP, a component of non-clathrin-coated vesicles
essential for membrane traffic. J. Bio. C.
-
Boyd,
J. M., Malstrom, S., Subramanian, T., Venkatesh, L. K., Schaeper, U., Elangovan,
B., D'Sa-Eipper, C., & Chinnadurai, G. (1994) Adenovirus ElB 19 kDa
and Bc1-2 proteins interact with a commom set of cellular proteins. Cell
79:341-351.
-
Bram,
R. J., & G. R. Crabtree. (1994) Calcium signalling in T cells stimulated
by a cyclophilin B-binding protein. Nature 371:355-358.
-
Brondyk, W. H.; McKiernan, C. J.; Fortner, K. A.; Stabila, P.; Holz,
R. W.; & Macara, I. G. (1995) Interaction cloning of Rabin3, a novel
protein that associates with the Ras- like GTPase Rab3A. Mol. Cell Biol.
15:1137-1143.
-
Brown,
N. G., Costanzo, M. C., &. Fox, T. D. (1994). Interaction among three
proteins that specifically activate translation of the rnitochondrial COX3
mRN A in Saccharomyces cerevisiae. Mol. Cell. Biol . 14:1045-1053 .
-
Brou,
C., Logeat, F., Lecourtois, M., Vandekerckhove, J., Kourilsky, P., Schweisguth,
F., & Israel, A. (1994) Inhibition of the DNA-binding activity of Drosophila
suppressor of Hairless and its human homolog, KBF2/RBP-Jk, by direct protein-protein
interation with Drosophila hairless. Genes Dev. 8, 2491-503.
-
Buck, S. W.; & Shore, D. (1995) Action of a RAPl carboxy-terminal
silencing domain reveals an underlying competition between HMR and telomeres
in yeast. Genes & Dev. 9:370-384.
-
Bustelo,
X. R.; Suen, K. L.; Michael, W. M.; Dreyfuss, G.; & Barbacid, M. (1995)
Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding
proteins. Mol. Cell Biol. 15:1324-1332.
-
Chang,
E. C., Barr, M., Wang, Y., Jung, V., Xu, H-P., & Wigler, M. H. (1994)
Coopertive interaction of S. Pombe proteins required for mating and morphogenesis.
Cell 79:131-141.
-
Chardin,
P., Camonis, J. H., Gale, N. W., van Aelst, L., Schlessinger, J., Wigler,
M. H. & Bar-Sagi, D. (1993) Human Sosl: a guanine nucleotide exchange
factor for Ras that binds to GRB2. Science 260:1338-1343.
-
Chaudhuri,
B.; Hammerle, M.; & Furst, P. (1995) The interaction between the
catalytic A subunit of calcineurin and its autoinhibitory domain, in the
yeast two-hybrid system, is disrupted by cyclosporin A and FK506. FEBS
Letters 357: 221-226.
-
Cheng, G., Ye, Z-S., & Baltimore, D. (1994) Binding of Bruton's tyrosine kinase
to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.
Proc. Natl. Acad. Sci. USA. 91:8152-8155.
-
Cheng,
G., Cleary, A. M., Ye, A-s., Hong, D. I., Lederman, S., & Baltimore,
D. (1995) Involvement of CRAFl, a relative of TRAF, in CD40 signaling.
Science 267:1494-1498.
-
Chien, C. T., Bartel, P. L., Sternglanz, R. & Fields, S. (1991)
The two-hybrid system: A method to identify and clone genes for proteins
that interact with a protein of interest. Proc. Nat. Acad. Sci. USA, 88:9578-9582.
-
Chinkers,
M. (1994) Targeting of a distinctive protein-serine phosphatase to the
protein kinase-like domain of the atrial natriuretic peptide receptor.
Proc. Natl. Acad. Sci. USA. 91:1 1075-11079.
-
Chiu,
M. I., Katz, H., & Berlin, V. (1994) RAPTl, a mammalian homolog of
yeast Tor, interacts with the FKBP12/rapamycin complex. Proc. Natl. Acad.
Sci. USA. 91:12574- 12578.
-
Chevray, E. M., & Nathans, D. (1992) Protein interaction cloning
in yeast: identification of mammalian proteins that react with the leucine
zipper of Jun. Proc. Natl. Acad. Sci. USA. 89:5789-5793.
-
K.
Y. Choi, B. Satterberg, D. M. Lyons & E. A. Elion. Ste5 tethers multiple
protein kinases in the MAP kinase cascade required for mating in S. cerevisiae.
Cell 78, 499-512 (1994)
-
Clark,
K. L., Dignard, D., Thomas, D. Y. &. Whiteway M. (1993). Interaction
among the subunits of the G proteins involved in Saccharomyces cerevisiae
mating. Mol. Cell. Biol. 13: 1 -8.
-
Clemens,
K. E., R. Brent, J. Gyuris & K. Munger. (1995) Dimerization of the
human papillomavirus E7 oncoprotein in vivo. Virology 214: 289-293
-
Clifton, P., Hughes, J. E., & Takemoto, J. Y. (1994) SYR2: a
novel gene involved in the response to syringomycin. Abstracts of the general
meeting of the American Society for Microbiology. Las Vegas, Nevada. 94:18.
-
Coghlan, V. M., Perrino, B. A., Howard, M., Langeberg, L. K., Hicks,
J. B., Gallatin, W. M., & Scott, J. D. (1995) Association of protein
kinase A and protein phosphatase 2B with a common anchoring protein. Science
267:108-111.
-
Collart,
M. A. & Struhl, K. (1994) Notl (Cdc39), Not2 (Cdc36), Not3, and Not4
encode a global-negative regulator of transcription that affects TATA-element
utilization. Genes & Development 8:525-537.
-
Cortes,
P., Ye, Z-S., & Baltimore, D. (1994) RAG-l interacts with the repeated
amino acid motif of the human homolog of the yeast protein SRPl. Proc.
Natl. Acad. Sci. USA. 91:7633-7637.
-
Cress,
W. D.,& Nevins, J. R. (1994) Interactions of E2Fl, DPl, and the adenovirus
E4 protein. J. Virol. 7:4213-42 19.
-
Cuomo,
C. A., Kirch, S. A., Gyuris, J., Brent, R. & Oettinger, M. A. (1994)
Rchl, a protein that specifically interacts with the RAG-l recombination-activating
protein. Proc. Natl. Acad. Sci. USA. 91:6156-6160.
-
Dalton,
S. & Treisman, R. (1992) Characterization of SAP-l, a protein recruited
by serum response factor to the c-fos serum response element. Cell 68:597-612.
-
Donovan,
J. W., Milne, G. T., & Weaver, D. T. (1994) Homotypic and heterotypic
protein association control RadSl function in double-strand break repair.
Genes Dev. 8:2552-2562.
-
Dunaief,
J. L., Strober, B. E., Guna, S., Khavari, P. A., Alin, K., Luban, J., Begemann,
M., Crabtree, G. R., & Goff, S. P. (1994) The retinoblastoma protein
and BGRl form a complex and cooperate to induce cell cycle arrest. Cell
79:119-130.
-
Durfee,
T., Becherer, K., Chen, P. L., Yeh, S. H., Yang, Y., Kilbburn, A. E., Lee,
W. H. & Elledge, S. J. (1993) The retinoblastoma protein associates
with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7:555-569.
-
Durfee,
T., Mancini, M. A., Jones, D., Elledge, S. L., & Lee, W-H. (1994) The
amino- terminal region of the retinoblastoma gene product binds a novel
nuclear matrix protein that co-localizes to centers for RNA processing.
J. Cell Biol. 127:609-622.
-
E.
A. Elion, B. Satterberg & J. E. Kranz FUS3 phosphorylates multiple
components of the mating signal transduction cascade: evidence for STE12
and FAR1. Mol Biol Cell 4, 495-510 (1993)
-
Fabian,
J. R., Vojtek, A. B., Cooper, J. A., & Morrison, D. K. (1994) A single
amino acid change in Raf-l inhibits Ras binding and alters Raf-l function.
Proc. Natl. Acad. Aci. USA 91:5982-5986.
-
Fagan,
R., Flint K. J., & Jones, N. (1994) Phosphorylation of E2F-l modulates
its interaction with the Retinoblastoma gene product and the Adenoviral
E4 19 kDa protein. Cell, 78:799-811
-
Fantl,
W. J., Muslin, A. J., Kikuchi, A., Martin, J. A., Macicol, A. M., Gross,
R. W., & Williams, L. T. (1994) Activation of Raf-l by 14-3-3 proteins.
Nature 371:612-614.
-
Feaver,
W. J., Svejstrup, J. Q., Bardwell, L., Bardwell, A. J., Buratowski, S.,
Gulyas, K. D., Donahue, T. F., Friedberg, E. C., &. Kornberg, R. D.
(1993). Dual roles of a multiprotein complex from S. cerevisiae in transcription
and DNA repair. Cell, 75:1379-87
-
Feilotter,
H. E., Hannon, G. J., Ruddell, C. J., & Beach, D. (1994) Construction
of an improved host strain for two-hybrid screening. Nucleic Acids Res.
22:1502-1503 .
-
Fernandez-Sarabia,
M. J., &. Bischoff, J. R. (1993). Bcl-2 associates with the ras-related
protein R-ras p23. Nature (London). 366:274-275.
-
Fields, S. (1993) The two-hybrid system to detect protein-protein
interactions. Methods. 5:1 16-124.
-
Fields,
S. & Song, 0. (1989) A novel genetic system to detect protein-protein
interactions. Nature 340:245-247.
-
Fields, S., and Sternglanz, R. (1994). The two-hybrid system. Trends
in Genetics. 10:286- 292.
-
Finley,
R. L., & Brent, R. (1994) Interaction mating reveals binary and ternary
connections between Drosophila cell cycle regulators. Proc. Natl. Acad.
Sci. USA 91:12980-12984.
-
Freed,
E., Symons, M., Macdonald, S. G., McCormic, F., & Ruggieri, R. (1994)
Binding of 14-3-3 proteins to the protein kinase Raf and effects on its
activation. Science, 265:1713- 1716.
-
Fritz, C. C. & Green, M. R. (1992) Fishing for partners. Current
Biol. 2:403-405.
-
Fuchs, A., Dagher, M., & Vignais, P. V. (1995) Mapping the domains
of interaction of p40phox with both p47phox and p67phox of the neutrophil
oxidase complex using the two- hybrid system. J. Biol. Chem. 270:5695-5697.
-
Ferguson,
B., Horecka, J., Printen, J., Schultz, J., Stevenson, B. J., Sprague, G.
F. Jr. (1994) The yeast pheromone response pathway: new insight into signal
transmission. Cell. Mol. Biol. Res. 40:223-228.
-
Fury, M.; Zhang, W.; & Zieve, G. (1994) Protein-protein interactions
within and between the snRNP core particles. Mol. Biol.Cell 5 (suppl):215A.
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Geiser, J. R., Sundberg, H. A., Chang, B. H., Muller, E. G. D.,
&. Davis, R. N. (1993) The essential mitotic target of calmodulin is
the 110-kilodalton component of the spindle pole body in Saccharomyces
cerevisiae. Mol. Cell. Biol.13:7913-7924.
-
Gill, G., Pascal, E., Tseng, Z. H., &. Tjian, R. (1993) A glutamine-rich
hydrophobic patch in transcription factor Spl contacts the dTAFIIl10 component
of the Drosophila TFIID complex and mediates transcriptional activation.
Proc. Natl. Acad. Sci. USA. 9
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Goff,
S. A., Cone, K. C. & Chandler, V. L. (1992) Functional analysis of
the transcriptional activator encoded by the maize B: evidence for a direct
functional interaction between two classes of regulatory proteins. Genes
and Dev. 6: 864-875.
-
Guan,
K., Jenkins, C., Li, Y., Nochols, M. A., Wu, X. O'Keefe, C. L., Matera,
A. G., & Xiong, Y. (1994) Growth suppression by pl8, a pl6INK4/MTS1
and pl4'INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb
function. Genes & Devel. 8:2939-52
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Guarente, L. (1993) Strategies for the identification of interacting
proteins. Proc. Natl. Acad. Sci USA 90:1639-164 1.
-
Gyuris, J. Golemis, E. Chertkov, H. & Brent, R. (1993) Cdil, a human
Gl and S phase protein phosphatase that associate with Cdk2. Cell 75:791-803.
-
Habib,
T., Herrera, R., & Decker, S. J. (1994) Activators of protein kinase
C stimulate association of Shc and the PEST tyrosine phosphatase. J. Biol.
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Hannon, G. J., Casso, D., &. Beach, D. (1994). KAP: a dual specificity
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-
Hannon,
G. J., Demetrick, D., &. Beach, D. (1993). Isolation of the Rb-related
pl30 through its interaction with CDK2 and cyclins. Genes &. Devel.
7:2378-2391.
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Hardy,
C. F .J., Sussel, L. & Shore, D. (1992) A RAPl-interaction protein
involved in transcriptional silencing and telomere length regulation. Genes
and Dev. 6:801-814.
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* Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., &. Elledge,
S. J. (1993). The p21 Cdk-interacting protein Cipl is a potent inhibitor
of Gl cyclin-dependent kinases. Cell. 75:805-816.
-
He, F., & Jacobson, A. (1995) Identification of a novel componenet
of the non-sense- mediated mRNA decay pathway by using an interacting protein
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Hensey, C. E., Hong, F., Durfee, T., Qian, Y., Lee, E. Y., & Lee, W.
(1994) Identification of discrete structural domains in the retinoblastoma
protein. J. Biol. Chem. 269:1380-1387.
-
Hirst, K., Fisher, F., McAndrew, P. G., & Goding, C. R. (1994)
The transcription factor, the Cdk, its cyclin and their regulator: directing
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Hoey, T., Weinzierl, R. O.J., Gill, G., Chen, J., Dynlacht, B. D.,
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Hofer,
F.; Fields, S.; Schneider, C.; Martin, G. S. (1994) Activated Ras interacts
with the Ral guanine nucleotide dissociation stimulator. Proc. Natl. Acad
Sci USA. 91:11089-11093.
-
Hoeffler, J. P., Bilir, N., Marcell, T. Schneider, J. K., Dunkelberg,
J. C., & Jackson, S. M. (1994) Isolation of single-chain variable domains
with high-affinity antigen-binding characteristics using the two-hybrid
system in yeast. J. Cell. Biochem. Sup
-
Holt,
K. H., Olson, A. L., Moye-Rowley, W. S., &. Pessin, J. E. (1994). Phosphatidylinositol
3-kinase activation is mediated by high-affinity interactions between distinct
domains within the pl 10 and p85 subunits. Mol. Cell. Biol. 14:42-49.
-
Hu,
H. M., O'Rourke, K., Boguski, M. S., & Dixit, V. M. (1994) A novel
RING finger protein interacts with the cytoplasmic domain of CD40. J. Biol.
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Hu, T.; Ferril, S. C.; Snider, A-M.; & Barbosa, M. S.2. (1995)
In vivo analysis of HPV E7 protein association with pRb, plO7 and pl30.
International J. Oncology 6:167-174.
-
Huang,
Z. J., Curtin, K. D., & Rosbash, M. (1995) PER protein interactions
and temperature compesation of a circadian clock in Drosophila. Science
267:1169-72.
-
Hubbard,
E.J.A., Jiang, R. and Carlson, M. (1994). Dosage-dependent modulation of
glucose repression by MSN3 (STDl) in Saccharomyces cerevisiae. Mol. Cel.
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Irie, K., Gotoh, Y., Yashar, B. M., Errede, B., Nishida, E., & Matsumoto,
K. (1994) Stimulatory effects of yeast and mammalian 14-3-3 proteins on
the Raf proetin kinase. Science, 265:1716-1719.
-
Iwabuchi,
K., Bartel, P. L., Li, B., Bartel P. L., Marraccino, R. & Fields, S.
(1994) Two cellular proteins that bind to wild-type but not mutant pS3.
Proc. Natl. Acad Sci. USA. 91:6098-6102.
-
Iwabuchi, K., Li, B., Bartel, P. & Fields, S. (1993) Use of
the two-hybrid system to identify the domain of p53 involved in oligomerization.
Oncogene, 8:1693-1696.
-
Jackson,
A., Pahl, P. M., Harrison, K., Rosamond, J. & Sclafani, R. A. (1993)
Cell cycle regulation of the yeast cdc7 protein kinase by association with
the Dbf4 protein. Mol. Cell. Biol. 13:2899-2908.
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Jayaraman,
P-S., Hirst, K. & Goding, C. R. (1994) The activation domain of a basic
helix- loop-helix protein is masked by repressor interaction with domains
distinct from that required for transcription regulation. EMBO J. 13: 2192-2199.
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Johnson, F. B.; Parker, E.; & Krasnow, M. A. (1995) Extradenticle
protein is a selective cofactor for the Drosophila homeotics: role of the
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Kato,
G. J., Lee, W. M. F., Chen, L. & Dang, C. V. (1992) Max: Functional
domains and interaction with c-Myc. Genes and Dev. 6:81-92.
-
Kalpana,
G. V., &. Goff, S. (1993). Genetic analysis of homomeric interactions
of human immunodeficiency virus type 1 integrase using the yeast two-hybrid
system. Proc. Natl. Acad. Sci. USA. 90:10593-10597.
-
Kalpana,
G. V., Marmon, S., Wang, W., Crabtree, G. R., & Goff, S. P. (1994)
Binding and stimulation of HIV-l integrase by a human homolog of yeast
trascription factor SNFS. Science 266:2002-2006.
-
Kamper, J., Reichman, M, Romeis, T., Bolker, M., & Kahmann,
R. (1995) Multiallelic recognition: nonself-dependent dimerization of the
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Kikuchi, A., Demo, S. D., Ye, Z. H., Chen, Y. W., & Williams, L. T.
(1994) ral GDS family members interact with the effector loop of ras p21.
Mol. Cell Biol. 14:7483-7491.
-
Kitagawa, K.; Masumoto, H.; Ikeda, M.; & Okazaki, T. (1995)
Analysis of protein-DNA and protein-protein interactions of centromere
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Kranz, J. E. Satterberg, B. & Elion, E. A. (1994). The MAP kinase Fus3
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Lamb, J. R., Michaud, W. A., Sikorski, R. S., & Hieter, P. A.
(1994) Cdc16p, Cdc23p, and Cdc27p form a complex essential for mitosis.
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Lee, J. W., Moore, D. D., & Heyman R. A. (1994) A chimeric hormone
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Lee, J. W., Ryan, F., Swaffield, J. C., Johnson, S. A., More, D.
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mediator. Nature 473:91-94.
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Lee, J. W., H. S. Choi, J. Gyuris, R. Brent & D. D. Moore. (1995) Two
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Lee,
T. H., Elledge, S. J., & Butel, J. S. (1995) Hepatitis B virus X protein
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Legrain, P. & Chapon, C. (1993) Interaction between PRPl 1 and
SPP91 yeast splicing factors and characterization of a PRP9-PRPl l-SPP91
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Legrain,
P. & Chapon, C., & Galisson, F. (1993) Interaction between RPR9
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assembly. Gene Dev. 7:1390-1399.
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Legrain, P., Dokhelar, M. C., & C. Transy. (1994) Detection
of protein-protein interactions using different vectors in the two-hybrid
system. Nucleic Acids Res. 22:3241-3242.
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Lesage,
P., X. Yang & M. Carlson. (1994) Analysis of the SIP3 protein identified
in a two-hybrid screen for interaction with the SNF1 protein kinase. Nucleic
Acids Res 22, 597-603
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Li, B. &. Fields, S. (1993). Identification of mutations in
p53 that affect its binding to SV40 large T antigen by using the yeast
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Li, L., Elledge, S. J., Peterson, C. A. Bales, E. S. & Legerski,
R. J. (1994) Specific association between the human DNA repair proteins
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Li,
S., Janosch, P., Tanji, M., Rosenfeld, G. C., Waymire, J. C., Mischak,
H., Kolch, W., & Sedivy, J. (1995) Regulation of Raf-l kinase activity
by the 14-3-3 family of proteins. EMBO J. 14:685-696.
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Li, S., &. Sedivy, J. M. (1993). Raf-l protein kinase activates
the NF-KB transcription factor by dissociating the cytoplasmic NFkB-IkB
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Luban, J., Bossolt, K. L., Franke, E. K., Kalpana, G. V. & Goff,
S. P. (1993) Human immunodeficiency virus type 1 Gag protein binds to cyclophillins
A and B. Cell 73:1067- 1078.
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Luban, J., Alin, K. B., Bossolt, K. L., Humaran, T. & Goff, S. (1992)
Genetic assay for multimerization of retroviral gag polyproteins. J Virol.
66:5157-5160.
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Luo, Y., Yu, H., & Peterlin, B. M. (1994) Cellular protein
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68:3850-3856.
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MacDonald, P. N., Sherman, D. R., Dowd, D. R., Jefcoat, S. C. Jr.,
& Delise, R. K. (1995) The vitamin D receptor interacts with general
transcription factor IIB. J Biol. Chem. 270:4748-4752.
-
Makela,
T. P., Tassan, J., Nigg, E. A., Frutiger, S., Hughes, G. J., & Weinberg,
R. A. (1994) A cyclin associated with the CDK-activating kinase MO15. Nature
371:254-257.
-
Marcus,
G. A., Silverman. N., Berger, S. L., Horiuchi, J., & Guarente, L. (1994)
Functional similarity and physical association between GCNS and ADA2: putative
transcriptional adaptors. EMBO J. 13:4807-4815.
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Marcus,
S. Polverino, A., Barr, M., & Wigler, M. (1994) Complexes between STE5
and components of the pheromone-responsive mitogen-activated protein kinase
module. Proc. Natl. Acad. Sci. USA. 91:7762-7766.
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Matsuda, T., Saijo, M., Kuraoda, I., Kobayashi, T., Nakatsu, Y.,
Nagai, A., Enjoji, T., Masutani, C., Sugasawa, K., Hanaoka, F., Yasui,
A., & Tanaka, K. (1995) DNA repair protein XPA binds replication protein
A (RPA). J. Biol. Chem. 270:4152-4157.
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Meng, J-J.; Khan, S. A.; & Ip, W. (1994) Studying intermediate
filament domain interactions with the yeast two-hybrid system. Mol. Biol.Cell
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__________________
An upcoming paper in press contains two hybrid data for Bem1-Ste5, Cdc42-Ste20,
Bem1-Far1 interactions: Lyons, D.M., Mahanty, S., Choi, K-Y, Manandhar,
M. (1996) Mol. Cell. Biol., Vol.16 No.8 (August issue).
Find
the abstracts in MEDLINE