Selected Publications
Development:
Zaret, K.S. Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation. Nature Reviews Genetics 9, 329-340, 2008.
Lagha, M., Kormish, J.D., Rocancourt, D., Manceau, M., Epstein, J.A., Zaret, K.S., Relaix, F., and Buckingham, M.E. Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. Genes and Development 22, 1828-1837, 2008.
Calmont, A., Wandzioch, E., Tremblay, K.D., Minowada, G., Kaestner, K.H., Martin, G.R., and Zaret, K.S. An FGF-response pathway that mediates hepatic gene induction in embryonic endoderm cells. Developmental Cell 11, 339-348, 2006.
Jacquemin, P., Yoshitomi, H., Kashima, Y., Rousseau, G.G., Lemaigre, F.P., and Zaret, K.S. An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Developmental Biology 290, 189-199, 2006.
Bort, R., Signore, M., Tremblay, K.D., Martinez Barbera, J.P., and Zaret, K.S. Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Developmental Biology 290, 44-56,2006.
Tremblay, K.D. and Zaret, K.S. Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues. Developmental Biology 280: 87-99, 2005.
Bort, R., Martinez Barbera, J.P., Beddington, R.S.P., and Zaret, K.S. Hex Homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 131: 787-806, 2004.
Yoshitomi, H., and Zaret, K.S. Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development 131: 807-817, 2004.
Parviz, F., Matullo, C., Ning, G., Kaestner, K.H., Rossi, J., Zaret, K.S., and Duncan, S.A. Hepatocyte nuclear factors 4alpha controls the development of a hepaatic epithelium and liver organogenesis. Nature Genetics 34: 292-296, 2003.
Matsumoto, K., Yoshitomi, H., Rossant, J., and Zaret, K.S. Endothelial cells promoting liver organogenesis prior to vascular function. Science 294: 559-563, 2001.
Deutsch, G., Jung, J., Zheng, M., Lora, J., and Zaret, K.S. Bipotential precursor cell population for liver and pancreas within the embyonic endoderm. Development 128: 871-881, 2001.
Rossi, J.M., Dunn, N.R., Hogan, B.L.M., and Zaret, K.S. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes and Development 15: 1998-2009, 2001.
Chromatin - Transcription:
Sekiya, T., and Zaret, K.S. Repression by Groucho/TLE/Grg proteins: Genomic site recruitment generates compacted chromatin in vitro and impairs activator binding in vivo. Molecular Cell 28, 291-303, 2007.
Cuesta, I., Zaret, K.S., and Santisteban, P. The forkhead factor FoxE1 binds to the thryoperoxidase promoter during thyroid cell differentiation and modifies compacted chromatin structure. Molecular and Cellular Biology 27, 7302-7314, 2007.
Xu, J., Pope, S.D., Jazirehi, A.R., Attema, J.L., Papathanasiou, P., Watts, J. Zaret, K.S., Weissman, I.L., and Smale, S.T. Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells. Proceedings of the National Academy of Sciences, USA 104, 12377-12382, 2007.
Cirillo, LA, and Zaret, K.S. Specific interactions of the wing domains of FOXA1 transcription factor with DNA. Journal of Molecular Biology 366, 720-724, 2007.
Zaret, K.S. Stability and evolution of transcriptional regulatory networks. Molecular Systems Biology 2, 21, 2006.
Cirillo, L.A., Lin, F.R., Cuesta, I., Jarnik, M., and Zaret, K.S. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Molecular Cell 9:279-289, 2002.
Chaya, D., Hayamizu, T., Bustin, M., and Zaret, K.S. Transcription factor FoxA (HNF3) on a nucleosome at an enhancer complex in liver chromatin. J. Biological Chemistry 276:44385-44389, 2001.