Faculty Summaries
Yanis Boumber, MD, PhD
Yanis Boumber, MD, PhD
Assistant Professor
  • Clinical Investigator and Research Track
  • Thoracic Division, Department of Medical Oncology
Office Phone: (215) 728-3135
Office: W470

Peer-Reviewed Publications

  • Kuang SQ, Fang Z, Zweidler-McKay PA, Yang H, Wei Y, Gonzalez-Cervantes EA, Boumber Y, Garcia-Manero G. Epigenetic Inactivation of Notch-hes Pathway in Human B-cell Acute Lymphoblastic Leukemia. PLoS One 26;8(4):e61807, April 2013
  • Boumber Y, Kantarjian H, Jorgensen J, Faderl S, Castoro R, Autry J, Garcia-Manero G, Borthakur G, Jabbour E, Estrov Z, Cortes J, Issa JP, Ravandi F. Final Report of a Randomized Study of Decitabine Versus Conventional Care for Maintenance Therapy in Patients with Intermediate and High Risk Acute Myeloid Leukemia in First or Subsequent Complete Remission. Leukemia; 26 (11):2428-31, November 2012
  • Konishi K, Watanabe Y, Shen L, Guo Y, Castoro RJ, Kondo K, Chung W, Ahmed S, Jelinek J, Boumber YA, Estecio MR, Maegawa S, Kondo Y, Itoh F, Imawari M, Hamilton SR, Issa JP. DNA Methylation Profiles of Primary Colorectal Carcinoma and Matched Liver Metastasis. PLoS One; 6(11):e27889, 2011
  • Boumber Y, Younes A, Garcia-Manero G. Mocetinostat (MGCD0103): A Review of an Isotype-Specific Histone Deacetylase Inhibitor. Expert Opinion in Investigational Drugs;20(6):823-9, June 2011
  • Boumber Y and Issa, JP. Epigenetics- What's the Future? Oncology;25(3):220-6, 228, March 2011
  • Si J, Boumber YA, Shu J, Qin T, Ahmed S, He R, Jelinek J, Issa JP. Chromatin Remodeling is Required for Gene Reactivation After 5-aza-2'-deoxycytidine Mediated DNA Hypomethylation. Cancer Research,1;70(17):6968-77, Sept. 2010
  • Kondo Y, Shen L, Cheng AS, Ahmed S, Boumber Y, Charo C, Yamochi T, Urano T, Furukawa K, Kwabi-Addo B, Gold DL, Sekido Y, Huang TH, Issa JP. Gene Silencing in Cancer by Histone H3 lysine 27 Tri-methylation Independent of Promoter DNA Methylation. Nature Genetics,40(6):741-50, June 2008.
  • Kondo Y, Shen L, Ahmed S, Boumber Y, Sekido Y, Haddad BR, Issa JP. Downregulation of Histone H3 lysine 9 Methyltransferase G9a Induces Centrosome Disruption and Chromosome Instability in Cancer Cells. PLoS ONE.30;3(4):e2037, April 2008
  • Boumber YA, Kondo Y, Chen X, Shen L, Guo Y, Tellez C, Est├ęcio MR, Ahmed S, Issa JP. An Sp1/Sp3 binding polymorphism confers methylation protection. PLoS Genetics, 22;4(8):e1000162, Aug. 2008
  • Shen L, Kondo Y, Ahmed S, Boumber Y, Konishi K, Guo Y, Chen X, Vilaythong JN, Issa JP. Drug Sensitivity Prediction by CpG Island Methylation Profile in the NCI-60 Cancer Cell Line Panel. Cancer Research 1;67(23):11335-43, Dec. 2007
  • Boumber YA, Kondo Y, Chen X, Shen L, Gharibyan V, Konishi K, Estey E, Kantarjian H, Garcia-Manero G and Issa JP. RIL, A LIM Gene on 5q31, is Silenced by Methylation in Cancer and Sensitizes Cancer Cells to Apoptosis; Cancer Research; 67 (5):1997-2005, March 2007.