Faculty Summaries
Qi Kathy Cai, MD, PhD
Kathy Q. Cai, MD, PhD
Assistant Research Professor
  • Co-Director, Histopathology Facility
Office Phone: 215-214-3208
Fax: 215-728-3139
Office: W232


  • Dotan E, Meropol NJ, Zhu F, Zambito F, Bove B, Cai KQ, Godwin AK, Golemis EA, Astsaturov I, Cohen SJ. Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer. Br J Cancer. 2012 Feb 14;106(4):748-55.
  • Smith ER, Yeasky T, Wei JQ, Miki RA, Cai KQ, Smedberg JL, Yang WL, Xu XX. White spotting variant mouse as an experimental model for ovarian aging and menopausal biology. Menopause. 2012 May;19(5):588-96.
  • Behbakht K, Sill MW, Darcy KM, Rubin SC, Mannel RS, Waggoner S, Schilder RJ, Cai KQ, Godwin AK, Alpaugh RK. Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group study. Gynecol Oncol. 2011 Oct;123(1):19-26.
  • Capo-Chichi CD, Cai KQ, Smedberg J, Ganjei-Azar P, Godwin AK, Xu XX.. Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer. Chin J Cancer. 2011 Jun; 30(6):415-25.
  • Capo-Chichi CD, Cai KQ, Simpkins F, Ganjei-Azar P, Godwin AK, Xu XX. Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer. BMC Med. 2011 Mar 26; 9: 28.
  • Wang Y, Smedberg JL, Cai KQ, Capo-Chichi DC, Xu XX.. Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation. Dev Dyn. 2011 Mar;240(3):566-76.
  • Li, H., Cai, Q., Godwin, A.K., Zhang, R.G.Enhancer of zeste homolog 2 (EZH2) promotes the proliferation and invasion of epithelial ovarian cancer cells. 2010. Molecular Cancer Research, 2010 Dec;8(12):1610-8. Epub 2010 Nov 29.
  • Yang, G., Chang, B., Yang, F., Guo, X., Cai, K.Q., Xiao, X.S., Wang, H., Sen, S., Hung, M.C., Mills, G.B., Chang, S., Multani, A.S., Mercado-Uribe, I., Liu, J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin. Cancer Res. 16:3171-3181, 2010.
  • Smith, E.R., Cai, K.Q., Smedberg, J.L., Ribeiro, M.M., Rula, M.E., Slater, C., Godwin, A.K., Xu, X.X. Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells. PLoS One 5(2):e9295, 2010.
  • Smith, E.R., Cai, K.Q., Capo-chichi, C.D., Xu, X.X. Aberrant epithelial differentiation in ovarian cancer. Cancer Treat Res. 149:147-163, 2009. Did not use NIH funding.
  • Cai, K.Q., Caslini, C., Capo-chichi, C.D., Slater, C, Smith, E.R., Wu, H., Klein-Szanto, A., Godwin, A.K., Xu, X. Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia. PLoS ONE 4(7):e6454, 2009.
  • Moore, R., Cai, K.Q., Escudero, D.O., Xu, X.X. Cell adhesive affinity does not dictate primitive endoderm segregation and positioning during murine embryoid body formation. Genesis. 47(9):579-89, 2009.
  • Capo-chichi, C.D., Cai, K.Q., Testa, J.R., Godwin, A.K., Xu, X.X. Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer. Mol. Cell. Biol. 29:4766-4777, 2009.
  • Belinsky, M.G., Skorobagatko, Y.V., Rink, L., Pei, J., Cai, K.Q., Vanderveer, L., Riddell, D., Merkel, E., Tarn, C., von Mehren, M., Testa, J.R., Godwin, A.K. High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors. Genes Chromosomes Cancer 48:886-896, 2009.
  • Cai, K.Q., Wu, H., Klein-Szanto, A.J., Xu, X.X. Acquisition of a second mutation of the Tp53 alleles immediately precedes epithelial morphological transformation in ovarian tumorigenicity. Gynecol. Oncol. 114:18-25, 2009.
  • Yang, D.H., Smith, E.R., Cai, K.Q., Xu, X.X. C-Fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm development. Dev. Dyn. 238:514-523, 2009.
  • Belinsky, M.G., Rink, L., Cai, K.Q., Ochs, M.F., Eisenberg, B., Huang, M., von Mehren, M., Godwin, A.K. The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors. Cell Cycle 7:2949-2955, 2008.
  • Cai, K.Q., Capo-Chichi, C.D., Rula, M.E., Yang, D.H., Xu, X.X. Dynamic GATA6 expression in primitive endoderm formation and maturation in early mouse embryogenesis. Dev. Dyn. 237:2820-2829, 2008.
  • Yeager, N., Brewer, C., Cai, K.Q., Xu, X.X., Di Cristofano, A. Mammalian target of Rapamycin is the key effector of phosphatidylinositol-3-OH–initiated proliferative signals in the thyroid follicular epithelium. Cancer Res. 68:444-449, 2008. Paper accepted prior to April 7, 2008.
  • Rula, M.E.*, Cai, K.Q.*, Moore, R., Yang, D.H., Staub, C.M., Capo-Chichi, C.D., Jablonski S.A., Howe, P.H., Smith, E.R., Xu, X.X. Cell autonomous sorting and surface positioning in the formation of primitive endoderm in mouse blastocysts and embryoid bodies. Genesis 45:327-338, 2007. *Co-first authors.
  • Yang, D.H., Cai, K.Q., Roland, I., Smith, E.R., Xu, X.X. Disabled-2 is an epithelial surface positioning gene. J. Biol. Chem. 282:13114-13122, 2007.
  • Yang, W.L., Cai, K.Q., Smedberg, J.L., Smith, E.R., Klein-Szanto A, Hamilton T.C., Xu, X.X. A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumour phenotype in Wv mice. Am. J. Pathol. 170:1325-1336, 2007.
  • Cai, K.Q., Yang, W.L., Capo-Chichi, C.D., Vanderveer, L., Wu, H., Godwin, A.K., Xu, X.X. Prominent expression of metalloproteinases in early stages of ovarian tumorigenesis. Mol. Carcinog. 46:130-143, 2007.
  • Yang, D.H., Fazili, Z., Smith, E.R., Cai, K.Q., Klein-Szanto, A., Cohen, C., Horowitz, I.R., Xu, X.X. Disabled-2 heterozygous mice are predisposed to endometrial and ovarian neoplasm and exhibit sex-biased embryonic lethality in a p53 null background. Am. J. Pathol. 169:258-267, 2006.
  • Wang, C.F., Zhou, X.Y., Sun, M.H., Cai, Q., Zhang, T.M., Xu, Y., Cai, S.J., Shi, D.R. Two novel germline mutations of MLH1 in hereditary nonpolyposis colorectalcancer family. Chin. J. Pathol. 35:68-72, 2006.
  • Rosen, D.G., Cai, K.Q., Luthra, R., Liu, J. Immunohistochemical staining of hMLH1 and hMSH2 reflects microsatellite instability status in ovarian carcinoma. Mod. Pathol. 19:1414-20, 2006.
  • Cai, K.Q., Klein-Szanto, A., Karthik, D., Edelson, M., Daly, M.B., Ozols, R.F., Lynch, H.T., Godwin, A.K., Xu, X.X. Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations. Gynecol. Oncol. 103:719-728, 2006.
  • Rosen, D.G., Yang, G., Cai, K.Q., Bast, R.C. Jr., Gershenson, D.M., Silva, E.G., Liu, J. Subcellular localization of p27kip1 expression predicts poor prognosis in human ovarian cancer. Clin. Cancer Res. 11:632-637, 2005.
  • Yang, G., Cai, K.Q., Thompson-Lanza, J.A., Bast, R.C. Jr., Liu J. Inhibition of breast and ovarian tumor growth through multiple signaling pathways by using retrovirus-mediated siRNA silencing against her-2/neu gene expression. J. Biol. Chem. 279:4339-4345, 2004.
  • Cai, K.Q., Albarracin, C., Rosen, D. Zhong, R., Zheng, W., Luthra, R., Broaddus, R., Liu, J. Microsatellite instability and alteration of expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma. Hum. Pathol. 35:552-559, 2004.