Faculty Summaries
Paul Cairns, PhD
Paul Cairns, PhD
Associate Professor
  • Adjunct Associate Professor, Department of Biochemistry and Molecular Biology, Drexel University College of Medicine
Office Phone: 215-728-5635
Office: W350

Original Articles

  • Banumathy G, Cairns P. Signaling pathways in renal cell carcinoma. Cancer Biol Ther. 2010 Oct 4;10(7). [Epub ahead of print].
  • Ibragimova I, Ibáñez de Cáceres I, Hoffman AM, Potapova A, Dulaimi E, Al-Saleem T, Hudes GR, Ochs MF, Cairns P. Global reactivation of epigenetically silenced genes in prostate cancer. Cancer Prev Res (Phila). 2010 Sep;3(9):1084-92.
  • Diamandis EP, Sidransky D, Laird PW, Cairns P, Bapat B. Epigenomics-based diagnostics. Clin Chem. 2010 Aug;56(8):1216-9.
  • Cairns P. 5'-azacytidine expression arrays. Methods Mol Biol. 2009;507:165-74.
  • Brooks, J. Cairns, P., Zeleniuch-Jacquotte, A. Promoter methylation and the detection of breast cancer. Cancer Causes Control. 2009 Nov;20(9):1539-50.
  • Potapova A, Hoffman AM, Godwin AK, Al-Saleem T, Cairns P. Promoter hypermethylation of the PALB2 susceptibility gene in inherited and sporadic breast and ovarian cancer. Cancer Res. 2008 Feb 15;68(4):998-1002.
  • Cairns P. Gene methylation and early detection of genitourinary cancer: the road ahead. Nat Rev Cancer. 2007 Jul;7(7):531-43.
  • Ibanez de Caceres I, Dulaimi E, Hoffman AM, Al-Saleen T, Uzzo RG, Cairns P. Identification of novel target genes by an epigenetic reactivation screen of renal cancer. Cancer Res. 2006 May 15;66(10):5021-8.
  • Al-Saleem T, Cairns P, Dulaimi E, Feder M, Testa J, Uzzo R. The genetics of renal oncocytosis: A possible model for neoplastic progression. Cancer Genet Cytogenet. 2004;152:23-28.
  • Cairns P. Detection of promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patients. Ann NY Acad Sci. 2004;1022:40-43.
  • Cairns P, Adams PD. Clipped wings: Epigenetic inactivation of APC. Cancer Biol Ther. 2004;3:965-6.
  • Dulaimi E, Uzzo RG, Greenberg RE, Al-Saleem T, Cairns P. Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panel. Clin. Cancer Res. 2004;10:1887-93.
  • Dulaimi E, Hillinck J, Ibanez I, Cairns P. Tumor suppressor gene promoter hypermethylation in serum from breast cancer patients. Clin Cancer Res. 2004;10:6189-93.
  • Dulaimi E, Ibanez I, Uzzo RG, Al-Saleem T, Greenberg RE, Polasik T, Babb J, Grizzle W, Cairns P. Promoter hypermethylation of kidney cancer. Clin Cancer Res. 2004;10:3972-9.
  • Ibanez de Caceres I, Frolova N, Varkonyi R, Dulaimi E, Meropol NJ, Broccoli D, Cairns P. Frequent activation of telomerase in mismatch repair deficient tumors. Cancer Biol Ther. 2004;3:289-92.
  • Ibanez de Caceres I, Battagli C, Esteller M, Herman J, Dulaimi E, Edelson MI, Bergman C, Ehya H, Eisenberg BL, Cairns P. Tumor cell specific BRCA1 and RASSF1A hypermethylation in serum, plasma and peritoneal fluid from ovarian cancer patients. Cancer Res. 2004;64:6476-81.
  • Krassenstein R, Sauter E, Dulaimi E, Battagli C, Ehya H, Klein-Szanto A, Cairns P. Detection of breast cancer in nipple aspirate fluid by hypermethylation. Clin. Cancer Res. 2004;10:28-32.
  • Sauter G, Knowles M, Waldman F, Sidransky D, Cordon-Cardo C, Jones P, Cairns P. Pathology and genetics of tumours of the urinary system. In WHO Classification Tumors of the Urinary System, edited by J. Eble, G. Sauter, J. Epstein, I. Sesterhenn. IARC, pp. 89-154, 2004.
  • Abdollahi A, Pisarcik D, Roberts D, Weinstein J, Cairns P, Hamilton TC. LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer. J Biol Chem. 2003;278:6041-9.
  • Adams PD, Cairns P. Induction of the estrogen receptor by ablation of DNMT1 in ER-negative breast cancer cells. Cancer Biol Ther. 2003;2:557-8.
  • Battagli C, Uzzo R, Dulaimi E, Krassenstein R, Al-Saleem T, Greenberg RE, Cairns P. Tumor suppressor gene hypermethylation in urine DNA from kidney cancer patients. Cancer Res. 2003;63:8695-9.
  • Hoque MO, Lee C-CR, Cairns P, Schoenberg M, Sidransky D. Genome-wide genetic characterization of bladder cancer: A comparison of high-density single-nucleotide polymorphism arrays and PCR-based microsatellite analysis. Cancer Res. 2003;63:2216-22.
  • Prowse A, Schultz DC, Guo S, Vanderveer L, Dangel J, Bove B, Cairns P, Daly M, Godwin AK. Identification of a novel splice acceptor site mutation in p16INK4A/p14ARF within a breast cancer, melanoma, neurofibroma-prone kindred. J Med Genet. 2003;40:(8)102-8.
  • Uzzo RG, Cairns P, Al-Saleem T, Hudes G, Haas N, Greenberg RE, Kolenko V. The basic biology and immunobiology of renal cell carcinoma: Considerations for the clinician. Urol Clin N Am. 2003;30:423-6.
  • Cairns P, Sidransky D. Bladder Cancer, Chapter 44. In The Genetic Basis of Human Cancer, Second Edition, edited by B. Vogelstein and K. Kinzler. McGraw-Hill Inc., 2002.
  • Polascik TJ, Bostwick DG, Cairns P. Molecular genetics and histopathologic features of adult distal nephron tumors. Urology 2002;60:941-6.
  • Waldman FM, Jones PA, Knowles MA, Sidransky D, Cordon-Cardo C, Simon R, Cairns P. Pathology and genetics of tumors of the urinary system and male genital organs. In WHO Classification of Tumors, 2002.
  • Cairns P, Esteller M, Herman JG, Schoenberg M, Jeronimo C, Sanchez-Cespedes M, Chow N-H, Grasso M, Wu L, Westra WB, Sidransky D. Molecular detection of prostate cancer in urine by GSTP1 hypermethylation. Clin. Cancer Res. 2001;7:2727-30.
  • Cairns P, Sidransky D. Bladder Cancer, Chapter 54. In Metabolic and Molecular Basis of Inherited Disease, edited by C.R. Scriver, et al. McGraw-Hill Inc., pp. 1113-1118, 2001.