Faculty Summaries
Dr. Kerry Campbell
Kerry S. Campbell, PhD
Associate Professor
  • Director, Cell Culture Facility
Office Phone: 215-728-7761
Lab Phone: 215-728-7762
Fax: 215-728-2412
Office: R490

Human natural killer (NK) cells and cancer

  • Molecular mechanisms regulating the function of killer cell Ig-like receptors (KIR).
  • Profiling the phenotype and function of NK cells in cancer patients.
  • Therapeutic antibodies to target antitumor responses by human NK cells.
Description of research projects
Selected Publications
    1. Kikuchi-Maki, A., Catina, T.L., and Campbell, K.S. (2005) Cutting Edge: KIR2DL4 transduces signals into human NK cells through association with Fc receptor gamma protein. J. Immunol., 174:3859-3863.
    3. Alvarez-Arias, D.A., and Campbell, K.S. (2007) Protein kinase C regulates expression and function of inhibitory killer cell Ig-like receptors in NK cells. J. Immunol. 179: 5281–5290.
    5. Miah, S.M.S., Hughes, T.L., and Campbell, K.S. (2008) KIR2DL4 differentially signals downstream functions in human NK cells through distinct structural modules. J. Immunol. 180: 2922-2932.
    7. MacFarlane 4th, A.W., Yamazaki, T., Fang, M., Sigal, L.J., Kurosaki, T., and Campbell, K.S. (2008) Enhanced NK cell development and function in BCAP-deficient mice. Blood 112:131-140. PMCID: 2435684.
    9. Purdy, A.K. and Campbell, K.S. (2009) SHP-2 expression negatively regulates NK cell function. J. Immunol. 183:7234-7243. PMCID: 2783243.
    11. Miah, S.M.S., Purdy, A.K., Rodin, N.B., MacFarlane 4th, A.W., Oshinsky, J., Alvarez-Arias, D.A., and Campbell, K.S. (2011) Ubiquitylation of an internalized killer cell Ig-like receptor by Triad3A disrupts sustained NF-kappaB signaling. J. Immunol., 186:2959-2969. PMCID: 3079396.
    13. Campbell, K.S., and Purdy, A.K. (2011) Structure/Function of Human Killer Cell Ig-like Receptors: Lessons from Polymorphisms, Evolution, Crystal Structures, and Mutations. Immunology, 132:315-325, PMCID: 3044898.
    15. Grier, J.T., Forbes, L.R., Monaco-Shawver, L., Oshinsky, J., Atkinson, T.P., Moody, C., Pandey, R., Campbell, K.S., and Orange, J.S. (2012) Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity. J. Clin. Invest., 122:3769-3780. PMCID: 3461929.
    17. Campbell, K.S., and Hasegawa, J. (2013) NK cell biology: an update and future directions. J. Allergy Clin. Immunol., 132:536-544, PMCID: 3775709.
    19. Brusilovsky, M., Cordoba, M., Rosental, B., Hershkovitz, O., Andrake, M.D., Pecherskaya, A., Einarson, M.B., Zhou, Y., Braiman, A., Campbell, K.S., and Porgador, A. (2013) Genome-wide siRNA screen reveals a new cellular partner of NK cell receptor KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses. J. Immunol., 191:5256-5267. PMCID: 3836631.
    21. Mentlik James, A., Cohen, A.D., and Campbell, K.S. (2013) Combination therapies to enhance anti-tumor responses by NK cells. Front. Immunol., 4:481, PMCID: 3870292.
    23. MacFarlane 4th, A.W., Jillab, M., Plimack, E.R., Hudes, G.R., Uzzo, R.G., Litwin, S., Dulaimi, E., Al-Saleem, T., and Campbell, K.S. (2014) PD-1 expression on peripheral blood cells increases with stage in renal cell carcinoma patients and is rapidly reduced after surgical tumor resection. Cancer Immunol. Res., 2:320-331. PMCID: 4007343.
    25. Purdy, A.K., Alvarez-Arias, D.A., Oshinsky, J., James, A.M., Serebriiskii, I., and Campbell, K.S. (2014) The AP-2 clathrin adaptor mediates endocytosis of an inhibitory killer cell Ig-like receptor (KIR) in human NK cells. J. Immunol., 193:4675-4683. PMCID: 4269369.
    27. Brusilovsky, M., Radinsky, O., Cohen, L., Yossef, R., Shemesh, A., Braiman, A., Mandelboim, O., Campbell, K.S. and Porgador, A. (2015) Regulation of natural cytotoxicity receptors through interactions with heparin sulfate proteoglycans in -cis: a lesson from NKp44. Eur. J. Immunol., 45:1180-1191. PMCID: PMC4415513.
All publications