Wen-Chi Chang, PhD
Assistant Research Professor
Office Phone: 215-728-5368
Chemoprevention is a unique and promising strategy for reducing cancer risk through the administration of synthetic or dietary compounds. Further development of this important concept relies on the identification of compounds that have low toxicity and an understanding of their mechanisms of action. Administration of a dietary supplement that provides high-risk individuals with protection against cancer could significantly affect tumor incidence, mortality and morbidity.
Our research program focuses on the preclinical development of nutritional preventive regimens for individuals at increased risk for cancer. The overall goal is to contribute significantly to the prevention of tumorigenesis before it starts and/or the inhibition of tumor growth using naturally occurring compounds, such as nutrients.
- Hensley HH, Merkel CE, W-CL Chang, K Devarajan, HS Cooper and ML Clapper. Endoscopic imaging and size estimation of colorectal adenomas in the Multiple Intestinal Neoplasia mouse. Gastrointest Endosc. 2009;69(3)Suppl:742-9. PubMed
- Clapper ML, Gary MA, Coudry RA, Litwin S, Chang W-CL, Devarajan K, Lubet RA Cooper HS. 5 aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis. Inflamm Bowel Dis. 2008;14:1341-7. PubMed
- Clapper ML, Cooper HS, Chang W-CL. Dextran sulfate sodium-induced colitis-associated neoplasia – A promising model for the development of chemopreventive interventions. In: Molecular Targets, Biomarkers and Animal Models for Anti-Cancer Pharmacological Research: Potentials and Challenges from Chemoprevention to Chemotherapeutics. A.N.T. Kong (ed.). Acta Pharmacol. Sin., 28:1450-1459, 2007. PubMed
- Chang W-CL, Coudry RA, Clapper ML, Zhang X, Williams K, Spittle CS, Li T, Cooper HS. Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium. Carcinogenesis. 2007;28:2375-81. PubMed
- Wong Y-N, Chang W-C, Clapper M, Engstrom PF. Chemoprevention of colorectal cancer. In: Colorectal Cancer: Evidence-Based Chemotherapy Strategies. L.B. Saltz (ed.). Humana Press Inc., Totowa, NJ, pp. 33-49, 2006. PubMed
- Chang W-CL, Everley LC, Pfeiffer II, GR, Cooper HS, Barusevicius A, Clapper ML. Sulindac sulfone is most effective in modulating β-catenin-mediated transcription in cells with mutant APC. Ann NY Acad Sci. 2005 Nov;1059:41-55. PubMed
- Cooper HS, Chang W-C, Coudry R, Gary M, Everley L, Wang H, Litwin S, Clapper ML. Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min-FCCC) mice with significantly increased numbers of colorectal adenomas. Mol Carcinog. 2005 Sep;44(1):31-41. PubMed