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The Chen laboratory has had a long-standing interest in the field of cancer risk-assessment and molecular targeted prevention and our research has both a basic and translational focus. This includes: (1) the identification of novel breast cancer susceptibility genes by evaluating genes encoding novel proteins that function in pathways integrated with BRCA1/2 or by genome-wide allele-specific expression (ASE) analysis; (2) the development of RNAi-based breast cancer targeted therapy in these novel breast cancer susceptibility gene-related pathways; (3) the identification of novel serum biomarkers for breast cancer early detection.  Our research goal is to identify differences among normal, pre-malignant and cancerous breast tissue, determine their consequences, and use this information to improve the patient care.

1. Chen X, Weaver J, Bove BA, Vanderveer LA, Weil SC, Miron A, Daly MB, Godwin AK. Allelic Imbalance in BRCA1 and BRCA2 Gene Expression Is Associated with an Increased Breast Cancer Risk. Hum Mol Genet. 2008;17:1336-48. PubMed
2. Chen X, Truong TT, Weaver J, Bove BA, Cattie K, Armstrong BA, Daly MB, Godwin AK. Intronic alterations in BRCA1 and BRCA2: effect on mRNA splicing fidelity and expression. Human Mutation. 2006;27:427-35. PubMed
3. Chen X, Arciero CA, Wang C, Broccoli D, Godwin AK. BRCC36 is essential for IR-induced BRCA1 phosphorylation and nuclear foci formation. Cancer Res. 2006;66:5039-46. PubMed
4. Schilder RJ, Sill M W, Chen X, Darcy KM, Decesare SL, Lewandowski G, Lee RB, Arciero CA, Wu H, Godwin AK. Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group Study. Clin Cancer Res. 2005;11:5539-48. PubMed
5. Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R. Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell. 2003;12:1087-99. PubMed