Faculty Summaries
Jonathan Chernoff, PhD
Jonathan Chernoff, MD, PhD
Professor
  • Senior Vice President
  • Deputy Director
  • Chief Scientific Officer
  • Stanley P. Reimann Chair in Oncology Research
  • Co-Leader, Cancer Biology
Jonathan.Chernoff@fccc.edu
Office Phone: 215-728-5319
Lab Phone: 215-728-5320
Office: W455
Lab: W450-456
Role of Protein Phosphorylation in Neoplastic Transformation

The process of neoplastic transformation can be conceptually divided into two components. The first of these, proliferative transformation, refers to the ability of transformed cells to bypass growth suppression signals, dividing when normal cells would not. The second, morphologic transformation, refers to loss of normal cytoskeletal architecture, often accompanied by decreased adhesion and acquisition of the ability to invade surrounding tissues. These two fundamental properties are intimately linked to one another, although experimentally they can be dissected apart through the use of mutant oncogenes and other abnormal signaling molecules. The overall focus this research is in uncovering the roles of protein phosphorylation in governing these two fundamental aspects of cancer biology.

Description of research projects
Selected Publications
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  1. Arias-Romero LE, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy SK, Chernoff J. A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene Forthcoming 2010. PubMed
  2. Arias-Romero LE, Saha S, Villamar-Cruz O, Yip SC, Ethier SP, Zhang ZY, Chernoff J. Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. Cancer Res. 2009;69:4582-8. PubMed
  3. Allen JD, Jaffer ZM, Burgin S, Hofmann C, Sells MA, Derr-Yellin E, Michels EG, Bessler WK, Ingram DA, Chernoff J*, and Clapp DW.* p21-activated kinase 1 is required in mast cells for FceRI-mediated inflammatory responses. Blood. 2009;113:2695-705 *co-corresponding authors. PubMed
  4. Dadke S, Cotteret S, Yip SC, Jaffer ZM, Haj F, Ivanov A, Rauscher F, Shuai K, Ng T, Neel BG, Chernoff J. Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol. 2007;9:80-5. PubMed
  5. Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J, Peterson JR. An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase. Chem. Biol. 2008 15:322-31. PubMed
All publications