Jonathan Chernoff, MD, PhD
Office Phone: 215-728-5319
Lab Phone: 215-728-5320
|Principal Investigator||Title and Description||Affiliation, Dates|
P30 CA006927 Comprehensive Cancer Center Program at Fox Chase
The major goal of this Cancer Center Support Grant is to provide partial salary support for professional personnel, including senior and program leadership, administration, planning and evaluation, and developmental funds, as well as support for 5 established peer-reviewed Research Programs and 16 Shared Facilities. This grant includes a supplement for the American Russian Cancer Alliance (ARCA).
W81XWH-10-1-1005; Role of PTP1B in HER2 Signaling in Breast Cancer
The major goals of this project are: 1) To identify the key pro-oncogenic PTP1B regulated signaling pathways in ErbB2-transformed mammary epithelial cells; and 2) To validate the role of identified PTP1B substrates in bringing about the proliferative and morphogenetic effects of ErbB2 signaling in breast cancer. Dr. Chernoff serves as a Mentor on this grant.
R01 CA142928; Role of PTP1B in HER2 Signaling in Breast Cancer
p21-Activated Kinases as New Therapeutic Targets in Neurofibromatosis Type 1 The major goals of this project are 1) What are the key substrates of group A Paks in mast cells that affect cell motility? 2) What is the role of group A Paks in NF1-related signaling in Schwann cells? and 3) What is the cellular and molecular basis for Pak signaling in NF1-related pathology in vivo?
W81XWH-10-1-0092; Role of p21-Activated Protein Kinases in Neurofibromatosis 2
The major goal of this project is to determine if inhibiting group A Paks influences NF2-related pathology. Dr. Chernoff serves as a Mentor on this grant.
W81XWH-10-1-0181; Induced Pluripotent Stem Cells as Potential Therapeutic Agents in NF1
The major goals of this project are to: 1) Create iPS cells from Nf1+/- keratinocytes; 2) Repair the damaged Nf1 allele; 3) Convert the iPS cells to hematopoietic precursors; and 4) Transplant NF1 mouse with iPS-derived Nf1+/+ or Nf1+/- cells.
R01 NS066927; Pathophysiology of Conduction Block in HNPP
This project is a subcontract to Vanderbilt University Medical Center.
08-0049; p21-Activated Kinase-1 as a Novel Therapeutic Target in Asthma
The major goals of this SPAR project are: 1) To determine how Pak1 activity is regulated during mast cell activation; 2) To identify the substrates of Pak1 in mast cells that mediate its effects on degranulation andcytokine secretion; 3) To establish if loss of Pak1 function in mast cell affects airways responsiveness in mice; and 4) To determine if chemical Pak1 inhibitors reduce mast cell function.
American Asthma Foundation
IRG-92-027-17; ACS Institutional Research GrantThis grant is in a one year extension.
This is an Institutional Grant from the American Cancer Society that provides start-up funds for promising junior investigators to initiate innovative laboratory, clinical and translational research.
R01 CA117884; Signaling By p21-Activated Protein Kinases
The major goals of this project are: 1) How does Pak1 regulate centrosome function and genome stability?; 2) Role of Pak in ERK activation: what are its mechanisms of action?; and 3) How does loss of Pak signaling influence tumorigenesis?