Faculty Summaries
Jonathan Chernoff, PhD
Jonathan Chernoff, MD, PhD
Professor
  • Senior Vice President
  • Deputy Director
  • Chief Scientific Officer
  • Stanley P. Reimann Chair in Oncology Research
  • Co-Leader, Cancer Biology
Jonathan.Chernoff@fccc.edu
Office Phone: 215-728-5319
Lab Phone: 215-728-5320
Office: W455
Lab: W450-456

2010 - Present

  • Jhaveri KA, Debnath P, Chernoff J, Sanders J, Schwartz MA. The role of p21-activated kinase in the initiation of atherosclerosis. BMC Cardiovasc Disord. 2012 July 23;12:55-62. PMCID: PMC3489605
  • Hoover WC, Zhang W, Xue Z, Gao H, Chernoff J, Clapp DW, Gunst SJ and Tepper RS. Inhibition of p21-activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways. PLoS One 2012; 7(8):e42601. PMCID: PMC3416806
  • Chow H-Y, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, Duron SG, O’Farrell M, Cai KQ, Klein-Szanto AJ, Gutkind JS, Hoeflich KP and Chernoff J. p21-activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res. 2012; 72:5966-5975. PMCID: PMC3500416
  • Kelly ML and Chernoff J. Mouse models of PAK function. Cell Logist. 2012; 2:84-88. PMCID: PMC3490966
  • Chiang YA, Shao W, Xu XX, Chernoff J, Jin T. P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostatis in male C57BL/6 mice. Endocrinology 2013;154:77-88. PMID: 23183186 – In Process
  • Kosoff R, Chow H-Y, Radu M, Chernoff J. Pak2 Kinase Restrains Mast Cell Fc{epsilon}RI Receptor Signaling through Modulation of Rho Protein Guanine Nucleotide Exchange Factor (GEF) Activity. J. Biol. Chem. 2013; 288:974-983. PMCID: PMC3543047
  • Huynh N, Yim M, Chernoff J, Shulkes A, Baldwin GS, He H. P-21-Activated Kinase 1 Mediates Gastrin-Stimulated Proliferation in the Colorectal Mucosa via Multiple Signalling Pathways. Am. J. Physiol. Gastrointest. Liver Physiol. – In Process - PMID: 23306081
  • Menges CW, Sementino E, Talarchek J, Xu J, Chernoff J, Peterson JR, Testa JR. Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Mol Cancer Res 2012 Jul 12 [Epub ahead of print). Mol Cancer Res Sept 2012;10:1178-88. PMCID: PMC3447107
  • Semenova G, Chernoff J. PKM2 Enters the Morpheein Academy. Mol Cell. 2012 Mar 09;45(5):583-4.
  • Yip SC, Cotteret S, Chernoff J. Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin. J Cell Sci. 2012 Jan;125(2):310-6.
  • Monasky MM, Taglieri DM, Patel BG, Chernoff J, Wolska BM, Ke YB, Solaro RJ. p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. Am J Physiol Heart Circ Physiol 2012 Jan;302(1):H224-H230.
  • Taglieri DM, Monasky MM, Knezevic I, Sheehan KA, Lei M, Wang X, Chernoff J, Wolska BM, Ke YB, Solaro RJ. Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. J Mol Cell Cardiol. 2011 Dec;51(6):988-96.
  • Wang Z, Oh E, Clapp DW, Chernoff J, Thurmond DC. Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. J Biol Chem 2011 Dec 2;286(48):41359-41367.
  • Li A, Ma YF, Yu XZ, Mort RL, Lindsay CR, Stevenson D, Strathdee D, Insall RH, Chernoff J, Snapper SB, Jackson IJ, Larue L, Sansom OJ, Machesky LM. Rac1 Drives Melanoblast Organization during Mouse Development by Orchestrating Pseudopod-Driven Motility and Cell-Cycle Progression. Developmental Cell. 2011 Oct;21(4):722-34.
  • Sela M, Bogin Y, Beach D, Oellerich T, Lehne J, Smith-Garvin JE, Okumura M, Starosvetsky E, Kosoff R, Libman E, Koretzky G, Kambayashi T, Urlaub H, Wienands J, Chernoff J, Yablonski D. Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells. EMBO J. 2011 Aug;30(15):3160-72.
  • Delorme-Walker VD, Peterson JR, Chernoff J, Waterman CM, Danuser G, DerMardirossian C, Bokoch GM. Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. J Cell Biol. 2011 Jun;193(7):1289-303.
  • Shepelev MV, Chernoff J, Korobko IV. Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation. Small Gtpases 2011 Jan;2(1):17-26.
  • Makhlin I, Zhang J, Long CJ, Devarajan K, Zhou Y, Klein-Szanto AJ, Huang M, Chernoff J, Boorjian SA. The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers. BJU Int. 2011 Jul;108(2B):E84-E90.
  • De la Mota-Peynado A, Chernoff J, Beeser A. Identification f the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity. J Biol Chem 2011 Apr 15;286(15):13603-13611.
  • Van den Broeke C, Radu M, Nauwynck HJ, Chernoff J, Favoreel HW. Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase. Virus Res. 2011;155:376-380.
  • Kelly ML and Chernoff J. Getting smart about p21-activated kinases. Mol Cell Biol. 2011;31(3):386-387.
  • Huson SM, Acosta MT, Belzberg AJ, Bernards A, Chernoff J, Cichowski K, Gareth Events D, Ferner RE, Giovannini M, Korf BR, Listernick R, North KN, Packet RJ, Parada LF, Peltonen J, Ramesh V, Reilly KM, Risner JW, Schorry EK, Upadhyaya M, Viskochil DJ, Zhu Y, Hunter-Schaedle K, Giancotti FG. Back to the future: proceedings from the 2010 NF Conference. Am J Med Genet A. 2011;155(2):307-321.
  • De La Mota-Peynado A, Chernoff J, and Beeser A. Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity. J Biol Chem. 2011;286(15):13603-13611.
  • Arias-Romero LE, Chernoff J. p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target? Small Gtpases. 2010 Sep;1(2):124-8.
  • Pacheco A and Chernoff J. Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis. Int J Biochem Cell Biol. 2010;42(1):13-16.
  • Van den Broeke C, Radu M, Chernoff J and Favoreel HW. An emerging role for p21-activated kinas (Paks) in viral infections. Trends in Cell Biol. 2010;20(3):160-169.
  • Yip J, Saha S and Chernoff J. PTP1B: a double agent in metabolism and oncogenesis. Trends Biochem Sci. 2010;35(8):442-449.
  • Menges C, Chen Y, Mossman B, Chernoff J, Yeung A and Testa JR. A Phosphotyrosine proteomic screen identifies multiple tyrosine kinase signaling pathways aberrantly activated in Malignant Mesothelioma. Genes & Cancer. 2010;1:493-505.
  • Arias-Romero L, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy S and Chernoff J. A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene. 2010;29:5839-5849.
  • Kosoff R and Chernoff J. LOV conquers (sm)All GTPases. 2010;F1000 Biol Rep 2.
  • Molli PR, Li DQ, Bagheri-Yarmand R, Pakala SB, Katayama H, Sen S, Iyer J, Chernoff J, Tsai MY, Nair SS and Kumar R. Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol. 2010;190:101-114.
  • Makhlin I, Zhang J, Long CJ, Devarajan K, Zhou Y, Klein-Szanto AJ, Huang M, Chernoff J and Boorjian S. The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upragulated in a subset of human bladder cancers. Brit J Urol. 2010 Nov 2;doi: 10.1111/j.1464-410X.2010.09844.x. [Epub ahead of print]
  • Chow H-Y, Stepanova D, Koch J and Chernoff J. p21-activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2. PLoS ONE. 2010;5:e13791. doi:10.1371/ journal.pone.0013791.
Top

2000 - 2009

  • Van den Broeke C, Radu M, Deruelle M, Nauwynck H, Hofmann C, Jaffer ZM, Chernoff J and Favoreel HW. Alpha-herpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by p21-activated kinases 1 and 2. Proc Natl Acad Sci. 2009;106:8707-8712.
  • Arias-Romero LE, Saha S, Villamar O, Yip S-C, Ethier SP, Zhang Z-Y and Chernoff J. Activation of Src by Protein Tyrosine Phosphatase (PTP)1B is required for ErbB2 transformation of breast epithelial cells. Cancer Res 2009;69:4582-4588.
  • Flaiz C, Chernoff J, Ammoun S, Peterson JR and Hanemann CR. PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Exp Neurology. 2009;218:137-144.
  • Radu M and Chernoff J. The DeMSTifiction of mammalian Ste20 kinases. Curr Biol. 2009;19(10):R421-R425.
  • Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U and Williams JC. Interaction with LC8 Is required for Pak1 nuclear import and is indispensable for Zebrafish development. PLoS ONE. 2009;4:e6025.
  • Allen JD, Jaffer ZM, Burgin S, Hofmann C, Sells MA, Derr-Yellin, E, Michels EG, Bessler WK, Ingram DA, Chernoff J* and Clapp DW* p21-activated kinase 1 is required in mast cells for FceRI-mediated inflammatory responses. Blood. 2009;113:2695-2705 *co-corresponding authors. (Allen and Jaffer, co-first authors, Chernoff and Clapp co-senior authors).
  • Arias-Romero LE, Chernoff J. A tale of two Paks. Biology of the cell. 2008;100(2):97-108.
  • Deacon SW, Beeser A, Fukui JA, et al. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chemistry & biology. 2008;15(4):322-31.
  • Mao K, Kobayashi S, Jaffer ZM, et al. Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. Journal of Molecular and Cellular Cardiology. 2008;44(2):429-34.
  • McDaniel AS, Allen JD, Park SJ, et al. Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. Blood. 2008;112(12):4646-54.
  • Smith SD, Jaffer ZM, Chernoff J, Ridley AJ. PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. Journal of Cell Science. 2008;121(Pt 22):3729-36.
  • Dadke S, Cotteret S, Yip SC, et al. Regulation of protein tyrosine phosphatase 1B by sumoylation. Nature Cell Biology. 2007;9(1):80-5.
  • Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. Journal of Cell Science. 2007;120(Pt 20):3700-12.
  • Rennefahrt UE, Deacon SW, Parker SA, et al. Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. The Journal of Biological Chemistry.. 2007;282(21):15667-78.
  • Thullberg M, Gad A, Beeser A, Chernoff J, Stromblad S. The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity. Oncogene. 2007;26(12):1820-8.
  • Cotteret S, Chernoff J. Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Molecular and Cellular Biology. 2006;26(8):3215-30.
  • Peterson JR, Chernoff J. Src transforms in a Cool way. Nature Cell Biology. 2006;8(9):905-7.
  • Pirruccello M, Sondermann H, Pelton JG, et al. A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. Journal of Molecular Biology. 2006;361(2):312-26.
  • ten Klooster JP, Jaffer ZM, Chernoff J, Hordijk PL. Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. The Journal of Cell Biology. 2006;172(5):759-69.
  • Bartholomew PJ, Jones CW, Benware A, Chernoff J, LaFlamme SE. Regulation of the catalytic activity of PTP1B: roles for cell adhesion, tyrosine residue 66, and proline residues 309 and 310. Experimental Cell Research. 2005;311(2):294-306.
  • Beeser A, Chernoff J. Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction. Methods. (San Diego, Calif 2005;37(2):203-7.
  • Beeser A, Jaffer ZM, Hofmann C, Chernoff J. Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. The Journal of Biological Chemistry. 2005;280(44):36609-15.
  • Cotteret S, Chernoff J. Pak GITs to Aurora-A. Developmental Cell. 2005;9:573-4.
  • Gonzalez Guerrico AM, Jaffer ZM, Page RE, Braunewell KH, Chernoff J, Klein-Szanto AJ. Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene. 2005;24(14):2307-16.
  • Leisner TM, Liu M, Jaffer ZM, Chernoff J, Parise LV. Essential role of CIB1 in regulating PAK1 activation and cell migration. The Journal of Cell Biology. 2005;170(3):465-76.
  • Li S, Depetris RS, Barford D, Chernoff J, Hubbard SR. Crystal Structure. of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure. 2005;13(11):1643-51.
  • Parsons M, Monypenny J, Ameer-Beg SM, et al. Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Molecular and Cellular Biology. 2005;25(5):1680-95.
  • Sorokina EM, Chernoff J. Rho-GTPases: new members, new pathways. Journal of Cellular Biochemistry. 2005;94(2):225-31.
  • Golemis EA, Chernoff J. Analysis and manipulation of intracellular signaling cascades. Methods. (San Diego, Calif 2004;32(4):347-8.
  • Hofmann C, Shepelev M, Chernoff J. The genetics of Pak. Journal of Cell Science. 2004;117(Pt 19):4343-54.
  • Jaffer ZM, Chernoff J. The cross-Rho'ds of cell-cell adhesion. The Journal of Biological Chemistry. 2004;279(34):35123-6.
  • Reynolds LF, de Bettignies C, Norton T, Beeser A, Chernoff J, Tybulewicz VL. Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. The Journal of Biological Chemistry. 2004;279(18):18239-46.
  • Cai D, Iyer A, Felekkis KN, et al. AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Research. 2003;63(20):6802-8.
  • Cassidy J, Aikins JW, Chernoff JJ. Children's peer selection: experimental examination of the role of self-perceptions. Developmental Psychology. 2003;39(3):495-508.
  • Cheung WL, Ajiro K, Samejima K, et al. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell. 2003;113(4):507-17.
  • Cotteret S, Jaffer ZM, Beeser A, Chernoff J. p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Molecular and Cellular Biology. 2003;23(16):5526-39.
  • Dadke S, Chernoff J. Protein-tyrosine phosphatase 1B as a potential drug target for obesity. Current Drug Targets. 2003;3(4):299-304.
  • Dadke S, Chernoff J. Protein-tyrosine phosphatase 1B mediates the effects of insulin on the actin cytoskeleton in immortalized fibroblasts. The Journal of Biological Chemistry. 2003;278(42):40607-11.
  • Deacon K, Mistry P, Chernoff J, Blank JL, Patel R. p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Molecular Biology of the Cell. 2003;14(5):2071-87.
  • Penzes P, Beeser A, Chernoff J, et al. Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron. 2003;37(2):263-74.
  • Xiao GH, Chernoff J, Testa JR. NF2: the wizardry of merlin. Genes, Chromosomes & Cancer. 2003;38(4):389-99.
  • Zegers MM, Forget MA, Chernoff J, Mostov KE, ter Beest MB, Hansen SH. Pak1 and PIX regulate contact inhibition during epithelial wound healing. The EMBO Journal. 2003;22(16):4155-65.
  • Astrinidis A, Cash TP, Hunter DS, Walker CL, Chernoff J, Henske EP. Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene. 2002;21(55):8470-6.
  • Cotteret S, Chernoff J. The evolutionary history of effectors downstream of Cdc42 and Rac. Genome Biology. 2002;3(2):REVIEWS0002.
  • Dadke S, Chernoff J. Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. The Biochemical Journal. 2002;364(Pt 2):377-83.
  • Jaffer ZM, Chernoff J. p21-activated kinases: three more join the Pak. The International Journal of Biochemistry & Cell Biology. 2002;34(7):713-7.
  • Li F, Adam L, Vadlamudi RK, et al. p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Reports. 2002;3(8):767-73.
  • Nikolic M, Chernoff J. High midsummer for small GTPases. Trends in Cell Biology. 2002;12(11):495-7.
  • Serebriiskii IG, Mitina O, Pugacheva EN, et al. Detection of peptides, proteins, and drugs that selectively interact with protein targets. Genome research 2002;12(11):1785-91.
  • Thiel DA, Reeder MK, Pfaff A, Coleman TR, Sells MA, Chernoff J. Cell cycle-regulated phosphorylation of p21-activated kinase 1. Curr Biol 2002;12(14):1227-32.
  • Xiao GH, Beeser A, Chernoff J, Testa JR. p21-activated kinase links Rac/Cdc42 signaling to merlin. The Journal of Biological Chemistry. 2002;277(2):883-6.
  • Mota M, Reeder M, Chernoff J, Bazenet CE. Evidence for a role of mixed lineage kinases in neuronal apoptosis. J Neurosci. 2001;21(14):4949-57.
  • Reeder MK, Serebriiskii IG, Golemis EA, Chernoff J. Analysis of small GTPase signaling pathways using p21-activated kinase mutants that selectively couple to Cdc42. The Journal of Biological Chemistry. 2001;276(44):40606-13.
  • Serebriiskii IG, Mitina OV, Chernoff J, Golemis EA. Two-hybrid dual bait system to discriminate specificity of protein interactions in small GTPases. Methods in Enzymology. 2001;332:277-300.
  • Adam L, Vadlamudi R, Mandal M, Chernoff J, Kumar R. Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. The Journal of Biological Chemistry. 2000;275(16):12041-50.
  • Arora VK, Molina RP, Foster JL, et al. Lentivirus Nef specifically activates Pak2. Journal of Virology. 2000;74(23):11081-7.
  • Dadke S, Kusari J, Chernoff J. Down-regulation of insulin signaling by protein-tyrosine phosphatase 1B is mediated by an N-terminal binding region. The Journal of Biological Chemistry. 2000;275(31):23642-7.
  • Dharmawardhane S, Schurmann A, Sells MA, Chernoff J, Schmid SL, Bokoch GM. Regulation of macropinocytosis by p21-activated kinase-1. Molecular Biology of the Cell. 2000;11(10):3341-52.
  • Sells MA, Pfaff A, Chernoff J. Temporal and spatial distribution of activated Pak1 in fibroblasts. The Journal of Cell Biology. 2000;151(7):1449-58.
  • Vadlamudi RK, Adam L, Wang RA, et al. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. The Journal of Biological Chemistry. 2000;275(46):36238-44.
  • Valster AH, Hepler PK, Chernoff J. Plant GTPases: the Rhos in bloom. Trends in Cell Biology. 2000;10(4):141-6.
Top

1990 - 1999

  • Chernoff J. Close encounters of the LIM-kinase. Nature Cell Biology. 1999;1(5):E115-7.
  • Chernoff J. Protein tyrosine phosphatases as negative regulators of mitogenic signaling. Journal of Cellular Physiology. 1999;180(2):173-81.
  • Sells MA, Boyd JT, Chernoff J. p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. The Journal of Cell Biology. 1999;145(4):837-49.
  • Adam L, Vadlamudi R, Kondapaka SB, Chernoff J, Mendelsohn J, Kumar R. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. The Journal of Biological Chemistry. 1998;273(43):28238-46.
  • Bubeck Wardenburg J, Pappu R, Bu JY, et al. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity. 1998;9(5):607-16.
  • Graves JD, Gotoh Y, Draves KE, et al. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. The EMBO Journal. 1998;17(8):2224-34.
  • Liu F, Sells MA, Chernoff J. Protein tyrosine phosphatase 1B negatively regulates integrin signaling. Curr Biol. 1998;8(3):173-6.
  • Liu F, Sells MA, Chernoff J. Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand. Molecular and Cellular Biology. 1998;18(1):250-9.
  • Sells MA, Barratt JT, Caviston J, Ottilie S, Leberer E, Chernoff J. Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast. The Journal of Biological Chemistry. 1998;273(29):18490-8.
  • Zhang B, Chernoff J, Zheng Y. Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. The Journal of Biological Chemistry. 1998;273(15):8776-82.
  • Bandyopadhyay D, Kusari A, Kenner KA, et al. Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin. The Journal of Biological Chemistry. 1997;272(3):1639-45.
  • Frank JC, Hirsch SH, Chernoff J, et al. Determinants of patient adherence to consultative comprehensive geriatric assessment recommendations. The Journals of Gerontology. 1997;52(1):M44-51.
  • Liu F, Chernoff J. Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor. The Biochemical Journal. 1997;327 ( Pt 1):139-45.
  • Sells MA, Chernoff J. Emerging from the Pak: the p21-activated protein kinase family. Trends in Cell Biology. 1997;7(4):162-7.
  • Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM, Chernoff J. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol. 1997;7(3):202-10.
  • Tang Y, Chen Z, Ambrose D, et al. Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Molecular and Cellular Biology. 1997;17(8):4454-64.
  • Creasy CL, Ambrose DM, Chernoff J. The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. The Journal of Biological Chemistry. 1996;271(35):21049-53.
  • Galisteo ML, Chernoff J, Su YC, Skolnik EY, Schlessinger J. The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. The Journal of Biological Chemistry. 1996;271(35):20997-1000.
  • Liu F, Hill DE, Chernoff J. Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas). The Journal of Biological Chemistry. 1996;271(49):31290-5.
  • Bagrodia S, Taylor SJ, Creasy CL, Chernoff J, Cerione RA. Identification of a mouse p21Cdc42/Rac activated kinase. The Journal of Biological Chemistry. 1995;270(39):22731-7.
  • Creasy CL, Chernoff J. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene. 1995;167(1-2):303-6.
  • Creasy CL, Chernoff J. Cloning and characterization of a human protein kinase with homology to Ste20. The Journal of Biological Chemistry. 1995;270(37):21695-700.
  • Knaus UG, Morris S, Dong HJ, Chernoff J, Bokoch GM. Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. Science. New York, NY 1995;269(5221):221-3.
  • Ottilie S, Miller PJ, Johnson DI, et al. Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. The EMBO Journal. 1995;14(23):5908-19.
  • Sells MA, Chernoff J. Epitope-tag vectors for eukaryotic protein production. Gene. 1995;152(2):187-9.
  • Sells MA, Chernoff J. Polymerase chain reaction cloning of related genes. Methods. in enzymology 1995;254:184-95.
  • Sells MA, Li J, Chernoff J. Delivery of protein into cells using polycationic liposomes. BioTechniques. 1995;19(1):72-6, 8.
  • Vambutas V, Kaplan DR, Sells MA, Chernoff J. Nerve growth factor stimulates tyrosine phosphorylation and activation of Src homology-containing protein-tyrosine phosphatase 1 in PC12 cells. The Journal of Biological Chemistry. 1995;270(43):25629-33.
  • Zhang S, Han J, Sells MA, et al. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. The Journal of Biological Chemistry. 1995;270(41):23934-6.
  • Patriotis C, Makris A, Chernoff J, Tsichlis PN. Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 1994;91(21):9755-9.
  • Reuben DB, Hirsch SH, Chernoff JC, et al. Project Safety Net: a health screening outreach and assessment program. The Gerontologist. 1993;33(4):557-60.
  • Ottilie S, Chernoff J, Hannig G, Hoffman CS, Erikson RL. The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis. Molecular and Cellular Biology. 1992;12(12):5571-80.
  • Ottilie S, Chernoff J, Hannig G, Hoffman CS, Erikson RL. A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases. Proceedings of the National Academy of Sciences of the United States of America. 1991;88(8):3455-9.
  • Chernoff J, Schievella AR, Jost CA, Erikson RL, Neel BG. Cloning of a cDNA for a major human protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences of the United States of America .1990;87(7):2735-9.
Top

1980 -1989

  • Chernoff J, Li HC. A major phosphotyrosyl-protein phosphatase from bovine heart is associated with a low-molecular-weight acid phosphatase. Archives of Biochemistry and Biophysics. 1985;240(1):135-45.
  • Sells MA, Chernoff J, Cerda A, et al. Long-term culture and passage of human fetal liver cells that synthesize albumin. In Vitro Cell Dev Biol. 1985;21(4):216-20.
  • Chernoff J, Sells MA, Li HC. Characterization of phosphotyrosyl-protein phosphatase activity associated with calcineurin. Biochemical and Biophysical Research Communications. 1984;121(1):141-8.
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