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The goals of my laboratory  is to investigate epigenetic mechanisms involved in breast cancer with the purpose of identifying pathways and compounds that would revert the methylated status of genes associated with cancer initiation and progression. Since aberrant gene methylation is one of the earliest molecular alterations occurring during cancer, it is a promising strategy for early detection. We have two projects ongoing at the present time.

1. Fernandez SV*. Estrogen, Alcohol Consumption and Breast Cancer. Alcoholism: Clinical and Experimental Research. Forthcoming 2010.
2. Wargon V, Fernandez SV, Goin M, Giulianelli S, Russo J, Lanari C. Hypermethylation of the progesterone receptor A in constitutive antiprogestin resistant mouse. Breast Cancer Res Treat. Breast Cancer Res Treat. 2010 May 4. PubMed
3. Fernandez SV*, Snider KE, Wu Y-Z, Russo IH, Plass C and Russo J. DNA- methylation changes in a human cell model of breast cancer progression. Mutat Res. 2010 Jun 1;688(1-2):28-35. Epub 2010 Mar 1. PubMed
4. Fernandez SV and Russo J. Estrogen and Xenoestrogens in Breast Cancer. Toxicol Pathol. 2010;38(1):110-22. PubMed
5. Kocdor H, Kocdor MA, Russo J, Snider KE, Vanegas JE, Russo IH, Fernandez SV*. Human chorionic gonadotropin (hCG) prevents the transformed phenotypes induced by 17 beta-estradiol in human breast epithelial cells. Cell Biol Int. 2009;33:1135-43. PubMed