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Dr. Godwin has been involved in both basic and translational research for many years, filling several important niches within Fox Chase Cancer Center (FCCC) and the translational research community as a whole (e.g., translational research initiatives, molecular pathology, biosample ascertainment). The central theme of his work centers on the idea of obtaining a molecular definition of a tumor to define its treatment-sensitive elements. As such, he has a long-standing interest in the field of cancer genetics and recent efforts in the study of molecular targeted therapies. His studies primarily involve three different types of cancer: breast, ovarian, and gastrointestinal stromal tumor (GIST). He uses these models to investigate how to improve patient care.

1. Belinsky MG, Skorobagatko Y, Rink LA, Pei J, Cai Q-K, Vanderveer L, Riddell D, Merkel E, Tarn C, von Mehren M, Testa J, Godwin AK. High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors. Genes, Chromosomes, and Cancer. 2009;48:886-96. PubMed
2. Rink L, Skorobogatko Y, Kossenkov A, Belinksy M, Pajak T, Heinrich MC, Ochs M, von Mehren M, Eisenberg B, Godwin AK. Genetic signatures indicate predictable rapid response to imatinib mesylate in the treatment of gastrointestinal stromal tumors. Molecular Cancer Therapeutics. 2009;8:2172-82. PubMed
3. Schilder RJ, Pathak HB, Lokshin AE, Holloway RW, Alvarez RD, Aghajanian Min H, Devarajan K, Ross E C, Drescher CW, Godwin AK. Phase II trial of single-agent cetuximab in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma with the potential for dose escalation to rash. Gynecologic Oncology. 2009 Jan 20;113:21-7. PubMed
4. Tarn C, Rink L, Merkel E, Flieder D, Pathak H, Koumbi D, Testa J, Eisenberg B, von Mehren M, Godwin AK. Insulin-like Growth Factor 1 Receptor is a Potential Therapeutic Target for Gastrointestinal Stromal Tumors. Proc Natl Acad Science USA. 2008;105:8387-92. PubMed
5. Chen X, Weaver J, Bove BA, Vanderveer L, Weil SC, Miron A, Daly MB, Godwin AK. Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk. Human Molecular Genetics. 2008;17:1336-48. PubMed
6. Chen X, Arciero CA, Wang C, Broccoli D, Godwin, AK. BRCC36 is essential for IR-induced BRCA1 phosphorylation and nuclear foci formation. Cancer Research. 2006;66:5039-46. PubMed
7. Tarn C, Skorobogatko YV, Taguchi T, Eisenberg B, von Mehren M, Godwin AK. Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms. Cancer Research. 2006;66:5477-86. PubMed
8. Chen X, Truong T-TN, Weaver J, Bove BA, Cattie K, Armstrong BA, Daly MB, Godwin AK. Intronic alterations in BRCA1 and BRCA2: effect on mRNA splicing fidelity and expression. Human Mutation. 2006;27:427-35. PubMed