Faculty Summaries
Sergei Grivennikov, PhD
Sergei Grivennikov, PhD
Member & Assistant Professor
Office Phone: 215-214-3974
Office: P2145
Lab: P2149

How immune and inflammatory pathway promote tumor growth and progression

  • Role of cytokines in tumor development.
  • Mechanisms of tumor elicited inflammation.
  • Role of inflammatoryt pathways in normal regeneration and in response to anti-cancer therapies.
  • Mouse models of inflammation and cancer.
Description of research projects
Selected Publications

Fox Chase Programs

    1. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010 Mar 19;140(6):883-99. PubMed PMID: 20303878.
    3. Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012 Nov 8;491(7423):254-8. PMID: 23034650 .
    5. Francescone R, Hou V, Grivennikov SI. Microbiome, inflammation, and cancer. Cancer J. 2014 May-Jun;20(3):181-9. PMID: 24855005.
    7. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 5;519(7541):57-62. PubMed PMID: 25731159.
All publications