Faculty Summaries
Kyoko Hayakawa, MD, PhD
Kyoko Hayakawa, MD, PhD
Office Phone: 215-728-5362
Fax: 215-728-3574
Lab: R388

2000 - present

  • Florence WC, Xia C, Gordy LE, Chen W, Zhang Y, Scott-Browne J, Kinjo Y, Yu KOA, Keshipeddy S, Pellicci DG, Patel O, Nielsen L-K, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcell SA, Howell AR, Hayakawa K, Gapin L, Zajonic DM, Wang PG, and Joyce S. Adaptability of the semi-invariant natural killer T cell receptor toward structurally diverse CD1d-restricted ligands. EMBO J. 2009;28:3579-90.
  • Rowley B, Tang L, Shinton S et al. Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptors. J Autoimmun. 2007;29(4):236-45.
  • Wen L, Shinton SA, Hardy RR et al. Association of B-1 B cells with follicular dendritic cells in spleen. J Immunol. 2005;174(11):6918-26.
  • Wen L, Brill-Dashoff J, Shinton SA et al. Evidence of marginal-zone B cell-positive selection in spleen. Immunity. 2005;23(3):297-308.
  • Hardy RR, Hayakawa K. Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes. Springer Semin Immunopathol. 2005;26(4):363-75.
  • Hardy RR, Wei CJ, Hayakawa K. Selection during development of VH11+ B cells: a model for natural autoantibody-producing CD5+ B cells. Immunol Rev. 2004;197:60-74.
  • Stanic AK, De Silva AD, Park JJ et al. Defective presentation of the CD1d1-restricted natural Vα14Jα18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency. Proc Natl Acad Sci USA. 2003;100(4):1849-54.
  • Hayakawa K, Asano M, Shinton SA et al. Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. J Exp Med. 2003;197(1):87-99.
  • Sriram V, Cho S, Li P et al. Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells. Proc Natl Acad Sci USA. 2002;99(12):8197-202.
  • Roberts TJ, Sriram V, Spence PM et al. Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT cells. J Immunol. 2002;168(11):5409-14.
  • Gui M, Li J, Wen LJ et al. TCR beta chain influences but does not solely control autoreactivity of V alpha 14J281T cells. J Immunol. 2001;167(11):6239-46.
  • Hardy RR, Hayakawa K. B cell development pathways. Annu Rev Immunol. 2001;19:595-621.
  • Hayakawa K, Shinton SA, Asano M et al. B-1 cell definition. Curr Top Microbiol Immunol. 2000;252:15-22.
  • Hayakawa K, Hardy RR. Development and function of B-1 cells. Curr Opin Immunol. 2000;12(3):346-53.
  • Hardy RR, Li YS, Allman D et al. B-cell commitment, development and selection. Immunol Rev. 2000;175:23-32.

1990 - 1999

  • Hayakawa K, Asano M, Shinton SA et al. Positive selection of natural autoreactive B cells. Science. 1999;285(5424):113-6.
  • Gui M, Wiest DL, Li J et al. Peripheral CD4+ T cell maturation recognized by increased expression of Thy-1/CD90 bearing the 6C10 carbohydrate epitope. J Immunol. 1999;163(9):4796-804.
  • Wasserman R, Li YS, Shinton SA et al. A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly. J Exp Med. 1998;187(2):259-64.
  • Maier CC, Bhandoola A, Borden W et al. Unique molecular surface features of in vivo tolerized T cells. Proc Natl Acad Sci USA. 1998;19(8):4499-503.
  • Burdin N, Brossay L, Koezuka Y et al. Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes. J Immunol. 1998;161(7):3271-81.
  • Hayakawa K, Li YS, Wasserman R et al. B lymphocyte developmental lineages. Ann NY Acad Sci. 1997;815:15-29.
  • Li YS, Wasserman R, Hayakawa K et al. Identification of the earliest B lineage stage in mouse bone marrow. Immunity. 1996;5(6):527-35.
  • Hardy RR, Li YS, Hayakawa K. Distinctive developmental origins and specificities of the CD5+ B-cell subset. Semin Immunol. 1996;8(1):37-44.
  • Kariv I, Hardy RR, Hayakawa K. Two distinct non-T helper type 2 interleukin-4+ cell subsets in mice as revealed by single-cell cytokine analysis. Eur J Immunol. 1994;24(3):549-57.
  • Kariv I, Hardy RR, Hayakawa K. Altered major histocompatibility complex restriction in the NK1.1+Ly-6Chi autoreactive CD4+ T cell subset from class II-deficient mice. J Exp Med. 1994;180(6):2419-24.
  • Hayakawa K, Tarlinton D, Hardy RR. Absence of MHC class II expression distinguishes fetal from adult B lymphopoiesis in mice. J Immunol. 1994;152(10):4801-7.
  • Dittrich F, Hayakawa K, Nimtz M et al. Identification of the mouse helper T lymphocyte differentiation antigen 3G11 as the ganglioside IV3(NeuAc)2-GgOse4Cer. Biochem Biophys Res Commun. 1994;200(3):1557-63.
  • Hardy RR, Hayakawa K. CD5 B cells, a fetal B cell lineage. Adv Immunol. 1994;55:297-339.
  • Li YS, Hayakawa K, Hardy RR. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med. 1993;178(3):951-60.
  • Kariv I, Hardy RR, Hayakawa K. Selective enrichment of major histocompatibility complex class II-specific autoreactive T cells in the thymic Thy0 subset. J Exp Med. 1993;177(5):1429-37.
  • Greer JM, Koerner TA, Hayakawa K et al. The 3G11+ antigen, a marker for murine CD4+ TH1 lymphocytes, is a ganglioside. Glycobiology. 1993;3(4):391-401.
  • Rogers PR, Pilapil S, Hayakawa K et al. CD45 alternative exon expression in murine and human CD4+ T cell subsets. J Immunol. 1992;148(12):4054-65.
  • Hayakawa K, Lin BT, Hardy RR. Murine thymic CD4+ T cell subsets: a subset (Thy0) that secretes diverse cytokines and overexpresses the V beta 8 T cell receptor gene family. J Exp Med. 1992;176(1):269-74.
  • Hayakawa K, Lin BT, Hardy RR. Murine CD4+ T-cell subsets generated by antigen-independent and dependent mechanisms. Chem Immunol. 1992;54:103-16.
  • Hardy RR, Hayakawa K. A developmental switch in B lymphopoiesis. Proc Natl Acad Sci USA. 1991;88(24):11550-4.
  • Hardy RR, Carmack CE, Shinton SA et al. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med. 1991;173(5):1213-25.
  • Hayakawa K, Hardy RR. Murine CD4+ T-cell subsets. Immunol Rev. 1991;123:145-68.
  • Holmes KL, Morse HC, 3rd, Makino M et al. A unique subset of normal murine CD4+ T cells lacking Thy-1 is expanded in a murine retrovirus-induced immunodeficiency syndrome, MAIDS. Eur J Immunol. 1990;20(12):2783-7.
  • Hayakawa K, Carmack CE, Hyman R et al. Natural autoantibodies to thymocytes: origin, VH genes, fine specificities, and the role of Thy-1 glycoprotein. J Exp Med. 1990;172(3):869-78.
  • Ernst DN, Hobbs MV, Torbett BE et al. Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J Immunol. 1990;145(5):1295-302.
  • Cerny A, Hugin AW, Hardy RR et al. B cells are required for induction of T cell abnormalities in a murine retrovirus-induced immunodeficiency syndrome. J Exp Med. 1990;171(1):315-20.
  • Carmack CE, Shinton SA, Hayakawa K et al. Rearrangement and selection of VH11 in the Ly-1 B cell lineage. J Exp Med. 1990;172(1):371-4.

1980 - 1989

  • Morse HC, 3rd, Yetter RA, Via CS et al. Functional and phenotypic alterations in T cell subsets during the course of MAIDS, a murine retrovirus-induced immunodeficiency syndrome. J Immunol. 1989;143(3):844-50.
  • Hayakawa K, Hardy RR. Phenotypic and functional alteration of CD4+ T cells after antigen stimulation. Resolution of two populations of memory T cells that both secrete interleukin 4. J Exp Med. 1989;169(6):2245-50.
  • Hardy RR, Carmack CE, Shinton SA et al. A single VH gene is utilized predominantly in anti-BrMRBC hybridomas derived from purified Ly-1 B cells. Definition of the VH11 family. J Immunol. 1989;142(10):3643-51.
  • Hayakawa K, Hardy RR. Normal, autoimmune, and malignant CD5+ B cells: the Ly-1 B lineage? Annu Rev Immunol. 1988;6:197-218.
  • Hayakawa K, Hardy RR. Murine CD4+ T cell subsets defined. J Exp Med. 1988;168(5):1825-38.
  • Hayakawa K, Ishii R, Yamasaki K et al. Isolation of high-affinity memory B cells: phycoerythrin as a probe for antigen-binding cells. Proc Natl Acad Sci USA. 1987;84(5):1379-83.
  • Hardy RR, Kishimoto T, Hayakawa K. Differentiation of B cell progenitors in vitro: generation of surface IgM+ B cells, including Ly-1 B cells, from Thy-1- asialoGM1+ cells in newborn liver. Eur J Immunol. 1987;17(12):1769-74.
  • Hardy RR, Hayakawa K, Shimizu M et al. Rheumatoid factor secretion from human Leu-1+ B cells. Science. 1987;236(4797):81-3.
  • Sidman CL, Shultz LD, Hardy RR et al. Production of immunoglobulin isotypes by Ly-1+ B cells in viable motheaten and normal mice. Science. 1986;232(4756):1423-5.
  • Hayakawa K, Hardy RR, Stall AM et al. Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage. Eur J Immunol. 1986;16(10):1313-6.
  • Hayakawa K, Hardy RR, Herzenberg LA. Peritoneal Ly-1 B cells: genetic control, autoantibody production, increased lambda light chain expression. Eur J Immunol. 1986;16(4):450-6.
  • Hardy RR, Dangl JL, Hayakawa K et al. Frequent lambda light chain gene rearrangement and expression in a Ly-1 B lymphoma with a productive kappa chain allele. Proc Natl Acad Sci USA. 1986;83(5):1438-42.
  • Hayakawa K, Hardy RR, Herzenberg LA. Progenitors for Ly-1 B cells are distinct from progenitors for other B cells. J Exp Med. 1985;161(6):1554-68.
  • Waldor MK, Hardy RR, Hayakawa K et al. Disappearance and reappearance of B cells after in vivo treatment with monoclonal anti-I-A antibodies. Proc Natl Acad Sci USA. 1984;81(9):2855-8.
  • Hayakawa K, Hardy RR, Honda M et al. Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proc Natl Acad Sci USA. 1984;81(8):2494-8.
  • Hardy RR, Hayakawa K, Parks DR et al. Murine B cell differentiation lineages. J Exp Med. 1984;159(4):1169-88.
  • Hayakawa K, Hardy RR, Parks DR et al. The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice. J Exp Med. 1983;157(1):202-18.
  • Hardy RR, Hayakawa K, Parks DR et al. Demonstration of B-cell maturation in X-linked immunodeficient mice by simultaneous three-colour immunofluorescence. Nature. 1983;306(5940):270-2.
  • Hardy RR, Hayakawa K, Haaijman J et al. B-cell subpopulations identified by two-colour fluorescence analysis. Nature. 1982;297(5867):589-91.
  • Herzenberg LA, Tokuhisa T, Hayakawa K. Epitope-specific regulation. Annu Rev Immunol. 1983;1:609-32.
  • Herzenberg LA, Tokuhisa T, Hayakawa K. Lack of immune response gene control for induction of epitope-specific suppression by TGAL antigen. Nature. 1982;295(5847):329-31.
  • Okumura K, Hayakawa K, Tada T. Cell-to-cell interaction controlled by immunoglobulin genes. Role of Thy-1-, Lyt-1+, Ig+ (B') cell in allotype-restricted antibody production. J Exp Med. 1982;156(2):443-53.

1970 - 1979

  • Shirai T, Hayakawa K, Okumura K et al. Differential cytotoxic effect of natural thymocytotoxic autoantibody of NZB mice on functional subsets of T cells. J Immunol. 1978;120(6):1924-9.
  • Taniguchi M, Hayakawa K, Tada T. Properties of antigen-specific suppressive T cell factor in the regulation of antibody response of the mouse. II.In vitro activity and evidence for the I region gene product. J Immunol. 1976;116(2):542-8.