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Cellular resistance to chemotherapeutic agents is a major obstacle to cancer treatment. ATP-binding cassette (ABC) transporters are involved in resistance by virtue of their ability to extrude drugs from the cell. Multidrug Resistance Proteins (MRPs) are drug efflux pumps that reside in the C family of ABC transporters - one of the largest families of ABC transporters. Similar to other family members, MRP7 is able to transport amphipathic anions, and MRP7 confers resistance to a wide variety of anticancer agents including taxanes, vinca alkaloids and nucleoside- based agents. Our laboratory is using a variety of models, biochemical, cellular and In vivo to further examine the role of MRP7 in cellular resistance.

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