Ongoing Research Support
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| Principal Investigator | Title and Description | Affiliation, Dates |
| Chernoff, J | A Growth-Regulating Protein Tyrosine Phosphatasem The major goals of this project are: 1) To determine the role of PTP1B in Src activation by growth factors and integrins; 2) To determine the molecular mechanisms of PTP1B effects on signal transduction in vivo; 3) To determine the mechanism by which PTP1B regulates cytokine signaling. |
National Institutes of Health 05/01/2003 – 04/30/2008 |
| Chernoff, J | Function of p21-activated Kinases The major goals of this project are: 1) to determine how Pak1 regulates centrosome function and genome stability 2) the role of Pak1 in ERK activation 3) the effect of loss of Pak1 signaling on tumorigenesis |
National Institutes of Health 01/01/2007 – 12/31/2011 |
| Chernoff, J | Analysis of p21-Activated Kinase Function in Neurofibromatosis Type 2 The major goals of this project are: 1) To determine the role of group A Paks in NF2-related signaling 2) To determine if Pak signaling influences NF2-related pathology in vivo |
DOD 12/01/2005 - 12/01/2009 |
| Chernoff, J | p21-Activated Kinase-1 as a Novel Therapeutic Target in Asthma The major goals of this project are: 1) To determine how Pak1 activity and scaffold functions are regulated during mast cell activation 2) To identify the substrates of Pak1 in mast cells that potentially mediate its effects on degranulation and cytokine secretion 3) To establish if loss of Pak1 function in mast cell affects airway responsiveness in mice 4) To determine if low molecular weight Pak1 inhibitors reduce mast cell function. |
Sandler Program in Asthma Research 07/01/2008 - 07/01/2011 |
| Chernoff, J Yablonski |
Spatio-temporal regulation of p21-activated kinases (Pak) in a T cell model system The goals of this project are: 1) to develop and apply technologies for visualizing the spatio-temporal regulation of Pak activity 2) to determine whether and how the spatio-temporal regulation of Pak influences MTOC (centrosome) orientation 3) to determine the role of activation-induced, ubiquitin-mediated degradation of Pak in regulating the spatio-temporal localization of Pak activity, and in regulating the activity of its binding partner, PIX. |
Binational Science Foundation 07/01/2008 - 07/01/2012 |
| Chernoff, J | The purpose of this project is to uncover drugs for treatment of NF2. We plan a synthetic lethal screen, using medium throughput screening of a chemical library that contains almost all FDA-approved small molecule drugs, to uncover compounds that are specifically required for the survival and/or proliferation of NF2-null cells | CTF Drug Discovery Initiative Award 09/01/2007 – 08/31/2008 |
| Seiden, M | Comprehensive Cancer Center Program This is an Institutional grant from the National Cancer Institute which provides salary support to Dr. Chernoff as Major Program Director. |
National Institutes of Health, 08/08/2005 – 06/30/2010 |