Identifying and Targeting Signaling Hubs in Cancer
Our laboratory is interested in defining the changes in cell signaling that occur as tumors spread by metastasis and develop resistance to drugs, with the ultimate goal of inhibiting these processes. Research in the laboratory has two major themes. Part of our research focuses on study of the Cas protein family, a group of proteins that provide scaffolds for signaling processes essential to cancer progression. Complementary projects use computer-based bioinformatic approaches to look for genes that sensitize cells to therapies targeted against cancer-promoting proteins. We hope through these studies to better define the interactions of signaling pathways in malignant cells.
Description of research projectsFox Chase Programs
- Personalized Kidney Cancer Therapy Keystone
- Epigenetics and Progenitor Cells Keystone
- Tumor Cell Biology
- Cellular and Developmental Biology
- Breast Cancer Research
- Developmental Therapeutics
Extramural Affiliations
- Singh MK, Dadke D, Nicolas E, Serebriiskii IG, Apostolou S, Canutescu A, Egleston BL, and Golemis EA. A novel Cas-family member, HEPL, regulates FAK and cell spreading. Mol Biol Cell, 2008 in press, Epub Feb 6, 2008. PubMed
- O’Neill GM, Seo S, Serebriiskii IG, Lessin SR, and Golemis EA. A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9. Cancer Res.2007 Oct 1;67(19) :8975--9. PubMed
- Pugacheva EN, Jablonski SA., Hartman TR, Henske EP, and Golemis EA. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 2007 Jun 29;129(7):1351-63. PubMed
- Singh MK., Nicolas E, Gherraby W, Dadke D, Lessin S, and Golemis EA. HEI10 negatively regulates cell migration by inhibiting cyclin B/Cdk1 and other pro-motility proteins. Oncogene. 2007 Jul 19;26(33):4825-32. PubMed
- Dadke D, Jarnik M, Pugacheva EN, Singh MK., and Golemis EA. Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle. Mol Biol Cell 2006 Mar;17(3):1204-17.. PubMed
- Pugacheva EN,and Golemis EA. The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nature Cell Biol. 2005 Oct;7(10):937-46. PubMed