Faculty Summaries
Eileen K. Jaffe, PhD
Eileen K. Jaffe, PhD
  • Adjunct Professor, Bichemistry, University of Pennsylvania School of Dental Medicine
  • Adjunct Professor, Biochemistry & Molecular Biology, Drexel University College of Medicine
  • Adjunct Professor, Department of Medical Genetics and Molecular Biochemistry, Temple University School of Medicine
Office Phone: 215 728-3695
Lab Phone: 215 728-5268
Fax: 215 728-2412
Office: R455
Lab: R452
Quaternary structure dynamics and the control of protein function


  • Morpheein model for protein allostery, for which the prototype is porphobilinogen synthase.
  • Allosteric regulation of Phenylalanine Hydroxylase, a putative morpheein.
  • Multimer-specific surface cavities as targets for the discovery of allosteric modulators (e.g. drugs).
Description of research projects
Selected Publications
    1. Ramirez UD, Nikonova AS, Liu H, Pecherskaya A, Lawrence SH, Serebriiskii IG, et al. Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization. BMC cancer. 2015;15:436. PMC4451962.
    2. Lentz CS, Halls VS, Hannam JS, Strassel S, Lawrence SH, Jaffe EK, et al. wALADin Benzimidazoles Differentially Modulate the Function of Porphobilinogen Synthase Orthologs. J Med Chem. 2014;57(6):2498-510. PMC3983392
    3. Lawrence SH, Selwood T, Jaffe EK. Environmental contaminants perturb fragile protein assemblies and inhibit normal protein function. Curr Chem Biol. 2013;7 PMC4102012.
    4. Jaffe EK, Stith L, Lawrence SH, Andrake M, Dunbrack RL, Jr. A new model for allosteric regulation of phenylalanine hydroxylase: implications for disease and therapeutics. Arch Biochem Biophys. 2013;530(2):73-82. PMC3580015.
    5. Jaffe EK. Impact of quaternary structure dynamics on allosteric drug discovery. Curr Top Med Chem. 2013;13(1):55-63. PMC3631351.
    6. Selwood T, Jaffe EK. Dynamic dissociating homo-oligomers and the control of protein function. Arch Biochem Biophys. 2012;519(2):131-43. PMC3298769.
    7. Jaffe EK, Lawrence SH. Allostery and the dynamic oligomerization of porphobilinogen synthase. Arch Biochemi Biophys. 2012;519(2):144-53. PMC3291741.
    8. Lawrence SH, Selwood T, Jaffe EK. Diverse clinical compounds alter the quaternary structure and inhibit the activity of an essential enzyme. ChemMedChem. 2011;6(6):1067-73. PMC3236527.
    9. Jaffe EK, Shanmugam D, Gardberg A, Dieterich S, Sankaran B, Stewart LJ, et al. Crystal Structure of Toxoplasma gondii Porphobilinogen Synthase: Insights on octameric structure and porphobilinogen formation. J Biol Chem. 2011;286(17):15298-307. PMC3083160.
    10. Jaffe EK. Morpheeins - a New Pathway for Allosteric Drug Discovery. Open Conf Proc J. 2010;1:1-6. PMC3107518.
    11. Lawrence SH, Ramirez UD, Tang L, Fazliyez F, Kundrat L, Markham GD, et al. Shape shifting leads to small-molecule allosteric drug discovery. Chem Biol. 2008;15(6):586-96. PMC2703447.
    12. Lawrence SH, Jaffe EK. Expanding the Concepts in Protein Structure-Function Relationships and Enzyme Kinetics: Teaching using Morpheeins. Biochem Mol Biol Educ. 2008;36(4):274-83. PMC2575429.
    13. Jaffe EK, Stith L. ALAD porphyria is a conformational disease. American Journal of Human Genetics. 2007;80(2):329-37.
    14. Jaffe EK. Morpheeins - a new structural paradigm for allosteric regulation. Trends in Biochemical Sciences. 2005;30(9):490-7.
    15. Breinig S, Kervinen J, Stith L, Wasson AS, Fairman R, Wlodawer A, et al. Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase. Nature Structural Biology. 2003;10(9):757-63.
All publications