Faculty Summaries
Dietmar J Kappes, PhD
Dietmar J Kappes, PhD
Professor
  • Co-Leader, Blood Cell Development and Cancer Keystone
  • Director, Transgenic Mouse Facility
Dietmar.Kappes@fccc.edu
Office Phone: 215-728-5374
Office: R292
Lab: R293

Publications

  • Jones-Mason, ME, Zhao, X, Kappes, D, Lasorella, A, Iavarone, A, Zhuang, Y. E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity 2012; 36:348-61. PubMed
  • Aliahmad, P, Kadavallore, A, de la Torre, B, Kappes, D, Kaye, J. TOX is required for development of the CD4 T cell lineage gene program. J Immunol 2011; 187:593159-40. PubMed
  • Kappes DJ. Developing intestinal fortitude. Nat Immunol. 2011; 12(4):281-2. PubMed
  • Kappes, DJ. Expanding roles for ThPOK in thymic development. Immunol Rev 2010; 238:182-94. PubMed
  • De Keersmaecker K, Real PJ, Della Gatta G, Palomero T, Sulis ML, Tosello V, Van Vlierberghe P, Barnes K, Castillo M, Sole X, Hadler M, Lenz J, Aplan PD, Kelliher M, Kee BL, Pandolfi PP, Kappes D, Gounari F, Petrie H, Van der Meulen J, Speleman F, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Soulier J, Avran D, Cave H, Dastugue N, Raimondi S, Meijerink JP, Cordon-Cardo C, Califano A, Ferrando AA. The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med. 2010; 16(11):1321-7. PubMed
  • Kim, ST, Touma, M, Takeuchi, K, Sun, ZY, Dave, VP, Kappes, DJ, Wagner, G, Reinherz, EL. Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors. J Immunol 2010; 185:2951-9. PubMed
  • Lee, SY, Stadanlick, J, Kappes, DJ, Wiest, DL. Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice. Semin Immunol 2010; 22:237-46. PubMed
  • Engel, I, Hammond, K, Sullivan, BA, He, X, Taniuchi, I, Kappes, D, Kronenberg, M. Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection. J Exp Med 2010; 207:1015-29. PubMed
  • He X, Park K, Kappes DJ. The role of ThPOK in control of CD4/CD8 lineage commitment. Annu Rev Immunol. 2010; 28:295-320. PubMed
  • Lauritsen JP, Wong GW, Lee SY, Lefebvre JM, Ciofani M, Rhodes M, Kappes DJ, Zuniga-Pflucker JC, Wiest DL. Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. Immunity. 2009; 31(4):565-75. PubMed
  • He X, Park K, Wang H, Zhang Y, Hua X, Li Y, Kappes DJ. CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity. 2008; 28(3):346-58. PubMed
  • Kappes D, Hagman J. Lymphocyte development - Regulation of B and T lymphoid cell development. Curr Opin Immunol. 2007; 19(2):113-5.
  • Kappes DJ. CD4 and CD8: Hogging all the Lck. Immunity. 2007; 27(5):691-3. PubMed
  • Haks, MC, Lefebvre, JM, Lauritsen, JP, Carleton, M, Rhodes, M, Miyazaki, T, Kappes, DJ, Wiest, DL. Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage. Immunity 2005; 22:595-606. PubMed
  • He, X, Dave, VP, Zhang, Y, Hua, X, Nicolas, E, Xu, W, Roe, BA, Kappes, DJ. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 2005; 433:826-33. PubMed
  • Hayes, SM, Laky, K, El-Khoury, D, Kappes, DJ, Fowlkes, BJ, Love, PE. Activation-induced modification in the CD3 complex of the gammadelta T cell receptor. J Exp Med 2002; 196:1355-61. PubMed
  • Malstrom, S, Tili, E, Kappes, D, Ceci, JD, Tsichlis, PN. Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus. Proc Natl Acad Sci USA 2001; 98:14967-72. PubMed
  • Delgado, P, Fernandez, E, Dave, V, Kappes, D, Alarcon, B. CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection. Nature 2000; 406:426-30. PubMed
  • Kappes, DJ, Lawrence, DM, Vaughn, MM, Davė, VP, Belman, AR, Rall, GF. Protection of CD3 delta knockout mice from lymphocytic choriomeningitis virus-induced immunopathology: implications for viral neuroinvasion. Virology 2000; 269:248-56. PubMed
  • Gui, M, Wiest, DL, Li, J, Kappes, D, Hardy, RR, Hayakawa, K. Peripheral CD4 T cell maturation recognized by increased expression of Thy-1/CD90 bearing the 6C10 carbohydrate epitope. J Immunol 1999; 163:4796-804. PubMed
  • Keefe, R, Dave, V, Allman, D, Wiest, D, Kappes, DJ. Regulation of lineage commitment distinct from positive selection. Science 1999; 286:1149-53. PubMed
  • Dave, VP, Allman, D, Wiest, DL, Kappes, DJ. Limiting TCR expression leads to quantitative but not qualitative changes in thymic selection. J Immunol 1999; 162:5764-74. PubMed
  • Dave, VP, Keefe, R, Berger, MA, Drbal, K, Punt, JA, Wiest, DL, Alarcon, B, Kappes, DJ. Altered functional responsiveness of thymocyte subsets from CD3delta-deficient mice to TCR-CD3 engagement. Int Immunol 1998; 10:1481-90. PubMed
  • Dave, VP, Allman, D, Keefe, R, Hardy, RR, Kappes, DJ. HD mice: a novel mouse mutant with a specific defect in the generation of CD4( ) T cells. Proc Natl Acad Sci USA 1998; 95:8187-92. PubMed
  • Berger, MA, Dave, V, Rhodes, MR, Bosma, GC, Bosma, MJ, Kappes, DJ, Wiest, DL. Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required. J Exp Med 1997; 186:1461-7. PubMed
  • Dave, VP, Cao, Z, Browne, C, Alarcon, B, Fernandez-Miguel, G, Lafaille, J, de la Hera, A, Tonegawa, S, Kappes, DJ. CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage. EMBO J 1997; 16:1360-70. PubMed
  • Kappes, DJ, Alarcon, B, Regueiro, JR. T lymphocyte receptor deficiencies. Curr Opin Immunol 1995; 7:441-7. PubMed
  • Monos, DS, Czanky, E, Ono, SJ, Radka, SF, Kappes, D, Strominger, JL. L cells expressing DQ molecules of the DR3 and DR4 haplotypes: reactivity patterns with mAbs. Immunogenetics 1995; 42:172-80. PubMed
  • Kappes, DJ, Browne, CP, Tonegawa, S. Identification of a T-cell-specific enhancer at the locus encoding T-cell antigen receptor gamma chain. Proc Natl Acad Sci USA 1991; 88:2204-8. PubMed
  • Kappes, DJ, Strominger, JL, Monos, DS. A novel method for generating stable high-level transfectants involving direct immunomagnetic selection for cell-surface epitopes: expression of HLA class-II genes in HeLa cells. Gene 1991; 108:245-52. PubMed
  • Kappes, DJ, Tonegawa, S. Surface expression of alternative forms of the TCR/CD3 complex. Proc Natl Acad Sci USA 1991; 88:10619-23. PubMed
  • Shin, J, Doyle, C, Yang, Z, Kappes, D, Strominger, JL. Structural features of the cytoplasmic region of CD4 required for internalization. EMBO J 1990; 9:425-34. PubMed
  • Bonneville, M, Ito, K, Krecko, EG, Itohara, S, Kappes, D, Ishida, I, Kanagawa, O, Janeway, CA, Murphy, DB, Tonegawa, S. Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors. Proc Natl Acad Sci USA 1989; 86:5928-32. PubMed
  • Kappes, D, Strominger, JL. Human class II major histocompatibility complex genes and proteins. Annu Rev Biochem 1988; 57:991-1028. PubMed
  • Kappes, DJ, Strominger, JL. Structure and evolution of the HLA class II SX beta gene. Immunogenetics 1986; 24:1-7. PubMed
  • Okada, K, Prentice, HL, Boss, JM, Levy, DJ, Kappes, D, Spies, T, Raghupathy, R, Mengler, RA, Auffray, C, Strominger, JL. SB subregion of the human major histocompatibility complex: gene organization, allelic polymorphism and expression in transformed cells. EMBO J 1985; 4:739-48. PubMed
  • Kappes, DJ, Arnot, D, Okada, K, Strominger, JL. Structure and polymorphism of the HLA class II SB light chain genes. EMBO J 1984; 3:2985-93. PubMed
  • Arnot, D, Lillie, JW, Auffray, C, Kappes, D, Strominger, JL. Inter-locus and intra-allelic polymorphisms of HLA class I antigen gene mRNA. Immunogenetics 1984; 20:237-52. PubMed
  • Collins, T, Korman, AJ, Wake, CT, Boss, JM, Kappes, DJ, Fiers, W, Ault, KA, Gimbrone, MA, Jr., Strominger, JL, Pober, JS. Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proc Natl Acad Sci USA 1984; 81:4917-21. PubMed
  • Auffray, C, Lillie, JW, Arnot, D, Grossberger, D, Kappes, D, Strominger, JL. Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. Nature 1984; 308:327-33. PubMed
  • Mullens, IA, Franke, J, Kappes, DJ, Kessin, RH. Developmental regulation of the cyclic-nucleotide-phosphodiesterase mRNA of Dictyostelium discoideum: analysis by cell-free translation and immunoprecipitation. Eur J Biochem 1984; 142:409-15. PubMed
  • BOOKS, CHAPTERS
  • Arnot, D, Auffray, C, Boss, J, Grossberger, D, Kappes, D, Korman, A, Kuo, J, Lillie, J, Okada, K, Roux Dosseto, M, Schamboeck, A, Strominger, JL. The HLA D region of the human major histocompatibility complex has been created by a large gene expansion. In: Progress in Immunology V, 5th International Congress of Immunology (Yamamura, Y, Tada, T, eds), pp 203 214. Academic Press, Tokyo, 1984.
  • Sorrentino, R, Auffray, C, Boss, J, Grossberger, D, Kappes, D, Levy, D, Lillie, J, Mengler, R, Okada, K, Prentice, H, Raghupathy, R, Spies, T, Strominger, JL. Major histocompatibility complex class II antigens: genes and proteins. In: Monoclonal Antibodies '84: Biological and Clinical Applications (Pinchera, A, Doria, G, Dammacco, F, Bargellesi, A, eds), pp 77-86, 1985.