Faculty Summaries
Andres J.P. Klein-Szanto, MD, PhD
Andres J.P. Klein-Szanto, MD, PhD
Professor
  • Director, Histopathology Facility
Andres.Klein-Szanto@fccc.edu
Office Phone: 215-728-3154
Lab Phone: 215-728-3155
Fax: 215-728-3139
Office: W270
Lab: W232
Research Interests

 

  • Role of the Pro-protein convertases furin and PACE-4 in cancer progression.
  • Pathobiology and pathogenesis of skin, oral mucosa and esophageal cancer.
Description of research projects
Selected Publications
    1. Li Y, Chitnis N, Nakagawa H, Kita Y, Natsugoe S, Yang Y, Li Z, Wasik MA, Klein-Szanto AJ, Rustgi AK, Diehl JA, PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers. Cancer Discov. 5:288-303, 2015. PMC4355177.
    2. Bassi D.E., Cenna J., Zhang J., Cukierman E. and Klein-Szanto A.J. Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6). Molec. Carcinogenesis (published on line) 2015.
    3. Vega M.E., Giroux V., Natsuizaka M., Liu M., Klein-Szanto A.J., Stairs D.B., Nakagawa H., Wang K.K., Wang T.C., Lynch J.B. & Rustgi A.K. Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4. Cell Cycle 13: 3857-3866, 2014. PMC number in progress.
    4. Kagawa S., Natsuizaka M., Whelan K., Facompre N., Naganuma S., Ohashi S., Basu D., Gimotty P., Klein-Szanto A., Bass A., Diehl J.A., Wong K., Rustgi A., Kinugasa H., Egloff A.M and Nakagawa H.,. Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor suppressor activities. Oncogene. 34:2347-2359, 2015. PMC4268095
    5. Wong G., Habibollahi P., Heidari P., Lee J., Klein-Szanto A.J., Waldron T., Gimotty P., Nakagawa H.,. Taylor P., Wang T., Mahmood U. and Rustgi A.K. Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice. Gastroenterol. 144:294-297, 2013. PMC3624041.
    6. Bassi D.E., Fu J., Zhang J., and Klein-Szanto A.J. The Role of Proprotein convertases in animal models of skin carcinogenesis. Colloquium Series on Protein Activation and Cancer, 1 (1): 1-60, 2012, San Rafael (CA): Morgan & Claypool Life Sciences
    7. Klein-Szanto A.J., Zhang J., and Bassi D.E. Proprotein Convertases in gynecological cancers. Colloquium Series on Protein Activation and Cancer, 1 (2): 1-43, 2012, San Rafael (CA): Morgan & Claypool Life Sciences.
    8. Fu J, Bassi DE, Zhang J, Li T, Nicolas E, Klein-Szanto AJ. Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth. Neoplasia. 2012 Apr;14(4):271-82. PubMed
    9. Cortellino S, Xu J, Sannai M, Moore R, Caretti E, Cigliano A, Le Coz M, Devarajan K, Wessels A, Soprano D, Abramowitz LK, Bartolomei MS, Rambow F, Bassi MR, Bruno T, Fanciulli M, Renner C, Klein-Szanto AJ, Matsumoto Y, Kobi D, Davidson I, Alberti C, Larue L, Bellacosa A. Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell. 2011 Jul 8;146(1):67-79. PubMed
    10. Goetz JG, Minguet S, Navarro-LeridaI, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ibanez T, Pellinen T, Echarri A, Klein-Szanto A.J, Garcia R, Keely P, Sanchez-Mateos P, Cukierman E, Del Pozo MA. Regulation of the biomechanical properties of the tumor microenvironment by stromal Caveolin-1 promotes invasion. Cell. 2011;146:148-63.
    11. Stairs, DB, Bayne L, Rhoades B, Vega ME, Waldron T, Kalabis J, Klein-Szanto AJ, Lee S, Katz J, Diehl A, Reynolds A, Vonderheide R, Rustgi AK. Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a bona fide tumor suppressor. Cancer Cell 19, 470-483, 2011.
    12. Bassi DE, Zhang J, Cenna J, Litwin S, Cukierman E, Klein-Szanto AJ. Proprotein Convertase Inhibition Results in Decreased Skin Cell Proliferation, Tumorigenesis, and Metastasis. Neoplasia. 2010 Jul;12(7):516-26. PubMed
    13. Lopez de Cicco R, Bassi D, Benavides F, Conti CJ, Klein-Szanto AJ. Inhibition of Proprotein Convertases: Approaches to Block Squamous Carcinoma Development and Progression. Molec Carcinog. 2007;46:654-659. PubMed
    14. Lopez de Cicco R, Bassi DE, Zucker S, Seidah NG, Klein-Szanto AJ. Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin. Cancer Res. 2005;65:4162-71. PubMed
    15. Bassi DE, Lopez de Cicco R, Cenna J, Cukierman E, Klein-Szanto AJ. PACE 4 Expression in Mouse Basal Keratinocytes Results in Basement Membrane Disruption and Acceleration of Tumor Progression. Cancer Res. 2005;65:7310-7319. PubMed
All publications