Faculty Summaries
Biao Luo, PhD
Biao Luo, PhD
Assistant Research Professor
  • Director, Institute for Personalized Medicine
Office Phone: 215-728-5677
Lab: P2040
Improve Cancer Treatment by the Application of Cancer Genomics

The ultimate goal of our research is to improve cancer treatment by the application of cancer genomics. Current efforts focus on the structural genomic and functional genomic analyses of cancer to identify patient-specific alterations that are important for development, progression and treatment of cancer. Areas of research include: 1) systematic identification of genetic alterations in cancer patients by high-throughput sequencing, 2) investigation of oncogenic networks perturbed by these genetic alterations with high-throughput functional screens. By deepening our understanding of cancer genetics, this research will contribute to developing clinical trials with new therapies and matching emerging drug treatments to the unique genetics of individual patient tumors.

Description of research projects
Selected Publications

Fox Chase Programs

  1. Zhang Q, Gu J, Liu J, Luo B, Cheung HW, Boehm JS, Root DE, Polyak K, Brown M, Richardson A, Hahn WC, Kaelin WG, Bommi-Reddy A. Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell. 2009;16:413-24. PubMed
  2. Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie D, Awad T, Zhou XC, Nguyen T, Piqani B, Li C, Golub T, Meyerson M, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE. Highly parallel identification of essential genes in cancer cells. Proc Natl Acad Sci U S A. 2008;105:20380-5. PubMed
  3. Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 2006;124:1283-98. PubMed
  4. Luo B, Heard AD, Lodish HF. Small interfering RNA production by enzymatic engineering of DNA (SPEED). Proc Natl Acad Sci U S A. 2004;101:5494-9. PubMed
  5. Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol. 1997;17:6057-67. PubMed
  6. Aster J, Pear W, Hasserjian R, Erba H, Davi F, Luo B, Scott M, Baltimore D, Sklar J. Functional analysis of the TAN-1 gene, a human homologue of Drosophila notch. Cold Spring Harb Symp Quant Biol. 1994;59:125-36. PubMed
All publications