Research in Gynecologic Oncology at Fox Chase is a multidisciplinary effort with an emphasis on the translation of basic science discoveries to clinical trials and patient care.  I collaborate with Dr. Paul Cairns on a project in our Ovarian Cancer SPORE exploring the role of epigenetic modification of genes in cancer development, prognosis and response to treatment. I am the principal investigator for clinical trials of the Gynecologic Oncology Group (GOG) and sit on the GOG’s developmental therapeutics and ovarian cancer committees. Working through the GOG, I am the principal investigator of an international clinical trial evaluating intraperitoneal chemotherapy combined with anti-angiogenesis therapy in the treatment of ovarian cancer.  In addition, as Chief of the Division of Gynecologic Oncology, our surgeons are often responsible for securing tumor tissue for Fox Chase’s Biosample Repository which supports basic research here and throughout the country.  We also collaborate with the Department of Cancer Prevention and Control, studying the role of stress on the immune response to the human papilloma virus (HPV),  psychotherapy in coping with the diagnosis and treatment of ovarian cancer and novel ways of addressing the needs of women at risk for developing gynecologic cancers.