Faculty Summaries
Jeffrey Peterson
Jeffrey R. Peterson, PhD
Associate Professor
  • Adjunct faculty appointment, Drexel University
Office Phone: 215-728-3568
Fax: 215-728-3574
Office: P3165
Lab: P3165
Kinase Signaling in Cancer

Protein kinases catalyze the transfer of a phosphate group from ATP onto proteins.  This simple reaction is one of the most widely used mechanisms in biology for controlling protein activity. Not surprisingly, protein kinases are frequently dysregulated in cancer and have become important therapeutic targets. We want to understand how kinases function normally in the cell, how they become dysregulated in cancer, and how their altered activity can be corrected with small molecule drugs. Our work sits at the interface of chemistry and biology and utilizes a broad range of techniques from high throughput screening, biochemistry, microscopy, and studies in cultured cells and model organisms including Drosophila and the mouse.

Description of research projects
Selected Publications
  1. Duong-Ly KC, Peterson JR. The human kinome and kinase inhibition. Curr Protoc Pharmacol 2013;Mar:Chapter 2, Unit 2.9. PubMed
  2. Malecka KA, Szentpetery Z, Peterson, JR. Synergistic activation of p21-activated kinase 1 by phosphatidylinositol 4,5-bisphosphate and Rho GTPases. J Biol Chem. 2013;288:8887-97. PubMed
  3. Strochlic TI, Concilio S, Viaud J, Eberwine R, Wong LE, Minden A, Turk BE, Plomann M, Peterson JR. Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking. Proc Natl Acad Sci USA. 2012;109:4116-21. PubMed
  4. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol. 2011;29:1039-45. PubMed
  5. Strochlic TI, Viaud J, Rennefahrt UEE et al. Phosphoinositides are essential co-activators for p21-activated kinase 1 (Pak1). Mol Cell. 2010;40(3):493-500. PubMed
  6. Viaud J and Peterson J. An allosteric kinase inhibitor binds the p21-activated kinase (Pak) autoregulatory domain covalently. Mol Cancer Ther. 2009;8(9):2559-65. PubMed
  7. Deacon SW, Beeser A, Fukui JA et al. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol. 2008;15(4):322-31. PubMed
All publications