Faculty Summaries
Jeffrey Peterson
Jeffrey R. Peterson, PhD
Associate Professor
  • Adjunct faculty appointment, Drexel University
Office Phone: 215-728-3568
Fax: 215-728-3574
Office: P3165
Lab: P3165

Original Articles

  • Fink LS, Beatty A, Devarajan K, Peri S, Peterson JR. Pharmacological profiling of kinase dependency in cell lines across triple-negative breast cancer subtypes. Mol Cancer Ther. 2015;14:298-306.
  • Strochlic TI, Stavrides KP, Thomas SV, Nicolas E, O'Reilly AM, Peterson JR. Ack kinase regulates CTP synthase filaments during Drosophila oogenesis. EMBO Rep. 2014;15(11):1184-91.
  • Beeharry N, Banina E, Khazak V, Deacon S, Andrake M, Egleston BL, Peterson, JR, Astsaturov I, Yen TJ. Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints. Cell Cycle. 2014;13(14):2172-91.
  • Chen C, Ha BH, Thevenin AF, Lou HJ, Zhang R, Yip KY, Peterson JR, Gerstein M, Kim PM, Filippakopoulos P, Knapp S, Boggon TJ, Turk BE. Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity. Mol Cell. 2013;53(1):140-7.
  • Anastassiadis T, Duong-Ly KC, Deacon SW, Lafontant A, Ma H, Devarajan K, Dunbrack RL Jr, Wu J, Peterson JR. A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-related kinase (ERK) inhibitor. J Biol Chem. 2013;288(39):28068-77.
  • Bitler BG, Fink LS, Wei Z, Peterson JR, Zhang R. A high-content screening assay for small molecule modulators of oncogene-induced senescence. J Biomol Screen. 2013;18(9):1054-61.
  • Duong-Ly KC, Peterson JR. The human kinome and kinase inhibition. Curr Protoc Pharmacol 2013;Mar:Chapter 2, Unit 2.9.
  • Rawat SJ, Creasy CL, Peterson JR, Chernoff J. The tumor suppressor mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein. J Biol Chem. 2013;288:8762-71.
  • Malecka KA, Szentpetery Z, Peterson, JR. Synergistic activation of p21-activated kinase 1 by phosphatidylinositol 4,5-bisphosphate and Rho GTPases. J Biol Chem. 2013;288:8887-97.
  • Ghosh A, Awasthi S, Peterson JR, Hamburger AW. Regulation of tamoxifen sensitivity by a PAK1-EBP1 signalling pathway in breast cancer. Br. J. Cancer 108:557-563, 2013.
  • Viaud J, Peterson JR. Identification of allosteric inhibitors of p21-activated kinase. Methods Mol Biol. 2012;928:67-79.
  • Malecka KA, Peterson JR. Face-to-Face, Pak-to-Pak. Structure 2011;19:1723-24, 2011.
  • Menges, C.W., Sementino, E., Talarchek, J., Xu, J., Chernoff, J., Peterson, J.R., Testa, J.R. Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Mol Cancer Res. 2012;10:1178-88.
  • Strochlic TI, Concilio S, Viaud J, Eberwine R, Wong LE, Minden A, Turk BE, Plomann M, Peterson JR. Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking. Proc Natl Acad Sci USA. 2012;109:4116-21.
  • Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol. 2011;29:1039-45.
  • Delorme-Walker VD, Peterson JR, Chernoff J, Waterman CM, Danuser G, DerMardirossian C, Bokoch GM Pak1 regulates focal adhesion strength, myosin IIA distribution and actin dynamics to optimize cell migration. J Cell Biol. 2011;193:1289-303.
  • Kadariya Y, Tang B, Myers CB, Fukui J, Peterson JR, Kruger WD. Chemical genetic screening for compounds that preferentially inhibit growth of methylthioadenosine phosphorylase (MTAP)-deficient Saccharomyces cerevisiae. J Biomol Screen. 2011;16(1):44-52.
  • Lichtenstein MP, Carrib, P, Baltrons MA, Wojciak-Stothard B, Peterson JR, Garcia A, Galea E. Secretase-independent and Rho GTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives. J Alzheimers Dis. 2010;22(4):1135-55.
  • Strochlic TI, Viaud J, Rennefahrt UEE et al. Phosphoinositides are essential co-activators for p21-activated kinase 1 (Pak1). Mol Cell. 2010;40(3):493-500.
  • Gauvin TJ, Fukui JA, Peterson JR et al. Isoform-selective chemical inhibition of mDia-mediated actin assembly. Biochemistry. 2009;48(40):9327-9.
  • Viaud J and Peterson J. An allosteric kinase inhibitor binds the p21-activated kinase (Pak) autoregulatory domain covalently. Mol Cancer Ther. 2009;8(9):2559-65.
  • Flaiz C, Chernoff J, Ammoun S, Peterson JR, Hanemann CO. PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Exp Neurol. 2009;18:137-144.
  • Gollmer K, Asperti-Boursin F, Tanaka Y et al. CCL21 mediates CD4+ T cell costimulation via a DOCK2/Rac-dependent pathway. Blood. 2009;114(3):580-8.
  • Malyukova I, Murray KF, Zhu C et al. Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis. Am J Physiol Gastrointest Liver Physiol. 2009;296(1):G78-92.
  • Deacon SW, Peterson JR. Chemical inhibition through conformational stabilization of Rho GTPase effectors. Handb Exp Pharmacol. 2008;(186):431-60.
  • Deacon SW, Beeser A, Fukui JA et al. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol. 2008;15(4):322-31.
  • Rennefahrt UE, Deacon SW, Parker SA et al. Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. J Biol Chem. 2007;282(21):15667-78.
  • Eswaran J, Lee WH, Debreczeni JE et al. Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. Structure. 2007;15(2):201-13.
  • Peterson JR, Lebensohn AM, Pelish HE et al. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol. 2006;13(4):443-52.
  • Peterson JR, Chernoff J. Src transforms in a Cool way. Nat Cell Biol. 2006;8 (9):905-7.
  • Pelish HE, Peterson JR, Salvarezza SB et al. Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol. 2006;2(1):39-46.
  • Perlman ZE, Bock JE, Peterson JR et al. Geometric diversity through permutation of backbone configuration in cyclic peptide libraries. Bioorg Med Chem Lett. 2005;15(23):5329-34.
  • Peterson JR, Golemis EA. Autoinhibited proteins as promising drug targets. J Cell Biochem. 2004;93(1):68-73.
  • Peterson JR, Bickford LC, Morgan D et al. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol. 2004;11(8):747-55.
  • Peterson JR, Mitchison TJ. Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton. Chem Biol. 2002;9(12):1275-85.
  • Peterson JR, Lokey RS, Mitchison TJ et al. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci USA. 2001;98 (19):10624-9.
  • Peterson JR, Helenius A. In vitro reconstitution of calreticulin-substrate interactions. J Cell Sci. 1999;112(Pt 16):2775-84.
  • Peterson JR, Helenius A. Mammalian calreticulin. In: MJ Gething, editor, Guidebook to Molecular Chaperones and Protein-Folding Catalysts. Oxford: Sambrook & Tooze Publication at Oxford University Press. 1997;p. 304-7.
  • Peterson JR, Ora A, Van PN et al. Transient, lectin-like association of calreticulin with folding intermediates of cellular and viral glycoproteins. Mol Biol Cell. 1995. 6(9):1173-84.
  • Hebert DN, Simons JF, Peterson JR et al. Calnexin, calreticulin, and Bip/Kar2p in protein folding. Cold Spring Harb Symp Quant Biol. 1995;60:405-15.
  • Olkkonen VM, Peterson JR, Dupree P et al. Isolation of a mouse cDNA encoding Rab23, a small novel GTPase expressed predominantly in the brain. Gene. 1994;138(1-2):207-11.
  • Cornell-Bell AH, Otake LR, Sadler K et al. Membrane glycolipid trafficking in living, polarized pancreatic acinar cells: assessment by confocal microscopy. Methods Cell Biol. 1993;38:221-40.
  • Arlinghaus HF, Thonnard N, Spaar MT et al. Comparison of sputter-initiated resonance ionization spectroscopy and laser atomization resonance ionization spectroscopy to localize tin-labeled deoxyribose nucleic acid. J Vac Sci Technol. 1991;9:1312-9.