Faculty Summaries
Glenn F Rall, PhD
Glenn F. Rall, PhD
  • Associate Academic Officer
  • Director, Postdoctoral Program
Office Phone: 215-728-3617
Lab Phone: 215-728-3677
Fax: 215-728-2412
Office: R493

Viral Infection, Immunity, and Disease in the Brain

  • Elucidating how neurotropic viruses spread to, and across, synaptic junctions
  • Defining principles that govern unique aspects of the  host immune response within the brain
  • Developing mouse models to study immunity to multiple pathogenic encounters
  • Evaluating long-term neuropathological consequences of viral infections
Description of research projects
Selected Publications
  1. O’Donnell, L.A., K. M. Henkins, A. Kulkarni, C. M. Matullo, S. Balachandran, A. K. Pattisapu, G. F. Rall.  Interferon gamma induces protective, non-canonical signaling pathways in primary neurons.  J. Neurochem., in press.
  2. Miller, K.D., Holmgren, A.M., S.E. Cavanaugh, G.F. Rall.  Bone marrow stromal antigen-2 (Bst2)/tetherin is induced by type I interferon and viral infection, but is dispensable for protection against neurotropic viral challenge.  J. Virology, in press.
  3. Cavanaugh, S.E., A.M. Holmgren, G.F. Rall.  Homeostatic interferon expression in neurons is sufficient for early control of viral infection.  J. Neuroimmunol, 279: 11-19, 2015.  PMCID: pending.
  4. Thapa, R.J., S. Nogusa, P. Chen, J.L. Maki, A. Lerro, M. Andrake, G.F. Rall, A. Degterev, S. Balachandran.  Interferon-induced RIP1/RIP3-dependent necrosis requires PKR and is licensed by FADD and caspases.  Proc. Natl. Acad. Sci., 110: E3109-118, 2013.  PMC3746924
  5. O'Donnell, L.A., S. Conway, R.W. Rose, E. Nicolas, M. Slifker, S. Balachandran, G.F. Rall.  STAT-1 independent control of a neurotropic measles virus challenge in primary neurons and infected mice.  J. Immunol., 188 (4): 1915-1923, 2012. PMCID: PMC3273675
  6. Gomme, E.A., C. Wirblich, S. Addya, G.F. Rall, M.J. Schnell.  Immune clearance of attenuated rabies virus results in neuronal survival with altered gene expression.  PLoS Pathogens, 8 (10):  e1002971, 2012. PMCID: PMC3469654
  7. Matullo, C.M., K.J. O’Regan, M. Curtis, G.F. Rall. CNS Recruitment of CD8+ T Lymphocytes specific for a peripheral virus infection triggers neuropathogenesis during polymicrobial challenge. PLoS Pathogens, 7 (12): e1002462, 2011. PMCID: PMC3245314
  8. Matullo, C.M., K.J. O'Regan, M. Curtis, H. Hensley, G.F. Rall.  Lymphocytic choriomeningitis virus-induced mortality in mice is triggered by edema and brain herniation.  J. Virol., 84: 312-320, 2010. PMCID: PMC2798401 PubMed
  9. Rose, R.W., A. Vorobyeva, J.D. Skipworth, E. Nicolas, G.F. Rall.  Altered levels of STAT1 and STAT3 influence the neuronal response to interferon gamma.  J. Neuroimmunol, 192: 145-156, 2007. PMCID: PMC2180831
  10. Makhortova, N., P. Askovich, C. E. Patterson, L. A. Gechman, N. P. Gerard, G. F. Rall. Neurokinin-1 enables measles virus trans-synaptic spread in neurons.  Virology, 362: 235-244, 2007. PMCID: PMC1945128 PubMed
  11. Patterson, C. E., J. K. Daley, L. A. Echols, T. E. Lane, G. F. Rall.  Measles virus infection induces chemokine synthesis by neurons.  J. Immunol. 171: 3102-3109, 2003.
  12. Patterson, C. E., D. M. Lawrence, L. A. Echols, G. F. Rall.  Immune-mediated protection from measles virus-induced central nervous system disease is noncytolytic and gamma interferon dependent. J. Virol. 76:4497-4506, 2002. PMCID: PMC155105
  13. Lawrence, D.M.P., C. E. Patterson, T.L. Gales, M. M. Vaughn, G. F. Rall.  Measles virus spread between neurons requires cell contact but not CD46 expression, syncytium formation or extracellular virus production.  J. Virol. 74: 1908-1918, 2000. PMCID: PMC111669
  14. Lawrence, D.M.P., M. M. Vaughn, A. R. Belman, J. S. Cole, G. F. Rall.  Immune response-mediated protection of adult but not neonatal mice from neuron-restricted measles virus infection and central nervous system disease.  J. Virol. 73: 1795-1801, 1999.
  15. Rall, G. F., M. Manchester, L. Daniels, E. Callahan, A. Belman, M. B. A. Oldstone. A transgenic mouse model for measles virus infection of the brain.  Proc. Natl. Acad. Sci. USA 94: 4659-4663, 1997. PMCID: PMC20780
All publications