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Temple Health
Temple University School of Medicine
Temple University
Irma H Russo, MD
Irma H Russo, MD
Associate Professor
Irma.Russo@fccc.edu
Office Phone: 215-728-4781

Recent Publications

  • Gutierrez PJ, Russo IH, Russo J. Cancer behaviour: an optimal control approach. International J Immunological Studies. 2009;1(1):31-65.
  • Moral R, Wang R, Russo IH, Lamartiniere CA, Pereira J, Russo J. Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression signature. J Endocrinol. 2008 Jan;196(1):101-12.
  • Russo J, Russo IH. Hormones and cancer. In: Berstein LM, Santen RJ, editors. Innovative endocrinology of cancer. New York Austin, Tex.: Springer Science+Business Media ; Landes Bioscience; 2008. p. 52-6.
  • Russo J, Russo IH. Breast architecture and the pathogenesis of cancer. In: Pasqualini JR, editor. Breast cancer : prognosis, treatment, and prevention. New York: Informa Healthcare; 2008. p. 1-9.
  • Russo J, Russo IH. Breast development, hormones and cancer. Adv Exp Med Biol. 2008;630:52-6.
  • Russo IH, Russo J. Use of human chorionic gonadotropin in the prevention of breast cancer. Women's Health. 2008;4(1):1-5.
  • Russo J, Balogh GA, Russo IH. Full-term pregnancy induces a specific genomic signature in the human breast. Cancer Epidemiology Biomarkers & Prevention. 2008 Jan;17(1):51-66.
  • Russo J, Russo IH. Breast development, hormones and cancer. In: Innovative Endocrinology of Cancer. Springer-Verlag Berlin; Heidelberger Platz 3, D-14197 Berlin, Germany; 2008. p. 52-6.
  • Moral R, Wang R, Russo IH, Mailo DA, Lamartiniere CA, Russo J. The plasticizer butyl benzyl phthalate induces genomic changes in rat mammary gland after neonatal/prepubertal exposure. BMC Genomics. 2007;8:453.
  • Mello ML, Vidal BC, Russo IH, Lareef MH, Russo J. DNA content and chromatin texture of human breast epithelial cells transformed with 17-beta-estradiol and the estrogen antagonist ICI 182,780 as assessed by image analysis. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 2007 Apr;617(1-2):1-7.
  • Russo IH, Russo J. Primary prevention of breast cancer by hormone-induced differentiation. Recent Results Cancer Res. 2007;174:111-30.
  • Russo J, Balogh G, Mailo D, Russo PA, Heulings R, Russo IH. The genomic signature of breast cancer prevention. Recent Results Cancer Res. 2007;174:131-50.
  • Russo J, Balogh G, Russo IH. Breast cancer prevention. Climacteric. 2007 Oct;10 Suppl 2:47-53.
  • Chen JQ, Russo PA, Cooke C, Russo IH, Russo J. ERbeta shifts from mitochondria to nucleus during estrogen-induced neoplastic transformation of human breast epithelial cells and is involved in estrogen-induced synthesis of mitochondrial respiratory chain proteins. Biochim Biophys Acta. 2007 Dec;1773(12):1732-46.
  • Balogh GA, Russo IH, Spittle C, Heulings R, Russo J. Immune-surveillance and programmed cell death-related genes are significantly overexpressed in the normal breast epithelium of postmenopausal parous women. Int J Oncol. 2007 Aug;31(2):303-12.
  • Balogh GA, Russo J, Mailo DA, Heulings R, Russo PA, Morrison P, Sheriff F, Russo IH. The breast of parous women without cancer has a different genomic profile compared to those with cancer. Int J Oncol. 2007 Nov;31(5):1165-75.
  • Balogh GA, Heulings R, Mailo DA, Russo PA, Sheriff F, Russo IH, Moral R, Russo J. Genomic signature induced by pregnancy in the human breast. Int J Oncol. 2006;28(2):399-410.
  • Fernandez SV, Russo PA, Fernbaugh R, Sheriff FS, Lareef HM, Garber J, Russo IH. 17-beta-estradiol induces transformation and tumorigenesis in human breast epithelial cells. The FASEB J. 2006;20:1622-34.
  • Fernandez, S.V., Russo, I.H., Russo, J. Estradiol and its metabolites 4-hydroxyestradiol and 2-hydroxyestradiol induce mutations in human breast epithelial cells. Int J Cancer, 118:1862-1868, 2006.
  • Russo J, Balogh GA, Chen JQ, Fernandez SV, Fernbaugh R, Heulings R, Mailo DA, Moral R, Russo PA, Sheriff F, Vanegas JE, Wang R, Russo IH. The concept of stem cell in the mammary gland and its implication in morphogenesis, cancer and prevention. Front Biosci. 2006 Jan 1;11:151-72.
  • Russo J, Balogh GA, Heulings R, Mailo DA, Moral R, Russo PA, Sheriff F, Vanegas J, Russo IH. Molecular basis of pregnancy-induced breast cancer protection. Eur J Cancer Prev. 2006 Aug;15(4):306-42.
  • Russo J, Russo IH. The role of estrogen in the initiation of breast cancer. J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):89-96.
  • Russo J, Santen RJ, Russo IH. Hormonal control of the breast development. In: DeGroot LJ, Jameson JL, editors. Endocrinology. Philadelphia, PA: W.B. Saunders Co.; 2005. p. 3045-55.
  • Chen J, Contreras R, Wang R, Fernandez S, Shoshani L, Russo I, Cereijido M, Russo J. Sodium/potasium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: a new paradigm for development of anti- breast cancer drugs?. Breast Cancer Res Treat. 2005 Dec;eFIRST date:2.
  • Fernandez SV, Russo IH, Lareef M, Balsara B, Russo J. Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites. Int J Oncol. 2005 Mar;26(3):691-5.
  • Lareef MH, Garber J, Russo PA, Russo IH, Heulings R, Russo J. The estrogen antagonist ICI-182-780 does not inhibit the transformation phenotypes induced by 17-beta-estradiol and 4-OH estradiol in human breast epithelial cells. Int J Oncol. 2005 Feb;26(2):423-9.
  • Meyer JS, Alvarez C, Milikowski C, Olson N, Russo I, Russo J, Glass A, Zehnbauer BA, Lister K, Parwaresch RG. Breast carcinoma malignancy grading by Bloom-Richardson system vs proliferation index: reproducibility of grade and advantages of proliferation index. Mod Pathol. 2005 Aug;18(8):1067-78.
  • Russo J, Mailo D, Hu YF, Balogh G, Sheriff F, Russo IH. Breast differentiation and its implication in cancer prevention. Clin Cancer Res. 2005 Part 2 Suppl. S JAN 15;11(2):931S-936S.
  • Russo J, Moral R, Balogh GA, Mailo D, Russo IH. The protective role of pregnancy in breast cancer. Breast Cancer Research. 2005;7(3):131-42.
  • Balogh GA, Russo IH, Russo J. Truncation of the mismatch repair protein PMS2 during the neoplastic transformation of human breast epithelial cells in vitro. Int J Oncol. 2004 Aug;25(2):381-7.
  • Guo SC, Russo IH, Lareef MH, Russo J. Effect of human chorionic gonadotropin in the gene expression profile of MCF-7 cells. Int J Oncol. 2004 Feb;24(2):399-407.
  • Lareef MH, Tahin Q, Song J, Russo IH, Mihaila D, Slater CM, Balsara B, Testa JR, Broccoli D, Grobelny JV, Mor G, Cuthbert A, Russo J. Chromosome 17p13.2 transfer reverts transformation phenotypes and Fas-mediated apoptosis in breast epithelial cells. Mol Carcinog. 2004 Apr;39(4):234-46.
  • Russo J, Russo IH. Genotoxicity of steroidal estrogens. Trends in Endocrinology and Metabolism. 2004 Jul;15(5):211-4.
    • Russo, J., Russo, I.H. A new paradigm in breast cancer prevention. Med. Hypotheses Res. 1:11-22, 2004.
  • Russo J, Russo IH. Development of the human breast. Maturitas. 2004 Sep 24;49(1):2-15.
  • Balogh GA, Russo IH, Russo J. Mutations in mismatch repair genes are involved in the neoplastic transformation of human breast epithelial cells. Int J Oncol. 2003 Aug;23(2):411-9.
  • Guo SC, Russo IH, Russo J. Difference in gene expression profile in breast epithelial cells from women with different reproductive history. Int J Oncol. 2003 Oct;23(4):933-41.
  • Lanza-Jacoby S, Miller S, Flynn J, Gallatig K, Daskalakis C, Masferrer JL, Zweifel BS, Sembhi H, Russo IH. The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in HER-2/neu mice. Cancer Epidemiology Biomarkers & Prevention. 2003 Dec;12(12):1486-91.
  • Russo J, Russo IH. (Editors) Biological and Molecular Basis of Breast Cancer. Springer-Verlag, Heidelberg, Germany, 2003.
  • Russo J, Lareef AH, Balogh G, Guo S, Russo IH. Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells. J Steroid Biochem Mol Biol. 2003 Oct;87(1):1-25.
  • Blumenstein R, Dias M, Russo IH, Tahin Q, Russo J. DNA content and cell number determination in microdissected samples of breast carcinoma in situ. Int J Oncol. 2002 Aug;21(2):447-50.
  • Jiang X, Russo IH, Russo J. Alternately spliced luteinizing hormone/human chorionic gonadotropin receptor mRNA in human breast epithelial cells. Int J Oncol. 2002 Apr;20(4):735-8.
  • Jiang X, Russo IH, Russo J. Human chorionic gonadotropin and inhibin induce histone acetylation in human breast epithelial cells. Int J Oncol. 2002 Jan;20(1):77-9.
  • Russo IH. Cigarette smoking and risk of breast cancer in women. Lancet. 2002 Oct 5;360(9339):1033-4.
  • Russo J, Lareef MH, Tahin Q, Hu YF, Slater C, Ao X, Russo IH. 17Beta-estradiol is carcinogenic in human breast epithelial cells. J Steroid Biochem Mol Biol. 2002 Feb;80(2):149-62.
  • Russo J, Tahin Q, Lareef MH, Hu YF, Russo IH. Neoplastic transformation of human breast epithelial cells by estrogens and chemical carcinogens. Environ Mol Mutagen. 2002;39(2-3):254-63.
  • Soler AP, Russo J, Russo IH, Knudsen KA. Soluble fragment of P-cadherin adhesion protein found in human milk. J Cell Biochem. 2002;85(1):180-4.
  • Jiang X, Russo IH, Russo J. Human chorionic gonadotropin and inhibin induce histone acetylation in human breast cancer cells. Int J Oncol. 2001;19:1-3.
  • Russo J, Hu YF, Silva ID, Russo IH. Cancer risk related to mammary gland structure and development. Microsc Res Tech. 2001 Jan 15;52(2):204-23.
  • Russo J, Hu YF, Tahin Q, Mihaila D, Slater C, Lareef MH, Russo IH. Carcinogenicity of estrogens in human breast epithelial cells. APMIS. 2001 Jan;109(1):39-52.
  • Russo J, Russo IH. The pathway of neoplastic transformation. Radiat Res. 2001;155:151-4.
  • Russo J, Santen R, Russo IH. Hormonal control of the breast development. In Endocrinology, Fourth Edition, edited by LJ DeGroot, JL Jameson. WB Saunders Company, Philadelphia, Vol.3, pp.2181-8. 2001
  • Russo J, Lynch H, Russo IH. Mammary gland architecture as a determining factor in the susceptibility of the human breast to cancer. Breast J. 2001 Sep-Oct;7(5):278-91.
  • Russo IH, Tahin Q, Huang Y, Russo J. Cellular and molecular changes induced by the chemical carcinogen benz(a)pyrene in human breast epithelial cells in association with smoking and breast cancer. Journal of Womens Cancer. 2001;3:29-36.
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