Faculty Summaries
Stephen M. Sykes, PhD
Stephen M. Sykes, PhD
Assistant Professor
  • Adjunct Professor, Temple University Medical School, Medical Genetics and Molecular Biology
Office Phone: 215-728-3539
Lab Phone: 215-728-3563
Office: W364

Normal and Malignant Hematopoietic Stem and Progenitor Cells

  • Define the molecular circuitry that distinguishes leukemia stem and progenitor cells from their healthy counterparts.
  • Identify and target critical regulators of redox biology to overcome chemotherapy resistance in acute myeloid leukemia (AML).
  • Targeting ER stress responses to treat certain genetic sub-types of AML.
Description of research projects
Selected Publications
    1. Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SA, Scholl C, Tothova Z, Attar E, Frohling S, DePinho RA, Gilliland DG, Armstrong SA, Scadden DT (2011). AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell. 2011 Sep 2;146(5):697-708. PMCID: PMC3826540.
    3. Faber K, Bullinger L, Ragu C, Garding A, Mertens D, Miller C, Martin D, Walcher D, Döhner K, Döhner H, Claus R, Plass C, Sykes SM, Lane SW, Scholl C, and Fröhling S. 2012. Myeloid leukemogenesis by CDX2 involves repression of KLF4 and deregulated PPARγ signaling. J Clin Invest. 2013 Jan 2;123(1):299-314. PMCID: PMC3533294.
    5. Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA & SA Armstrong. 2012. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell. 2012 Sep 7;11(3):429-39. PMCID: PMC3743253.
    7. Placke T, Faber K, Nonami A, Putwain SL, Salih HR, Heidel FH, Krämer A, Root DE, Barbie DA, Krivtsov AV, Armstrong SA, Hahn WC, Huntly BJ, Sykes SM, Milsom MD, Scholl C, Fröhling S. Requirement for CDK6 in MLL-rearranged acute myeloid leukemia. Blood. 2014 Jul 3;124(1):13-23.
    9. Saez B*, Ferraro F*, Yusuf RZ, Cook CM, Yu VWC, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaaguchi, Wager AJ, Scadden DT. Inhibiting mesenchymal cell heparan sulfate production alters stem cell localization and enables engraftment without cytotoxic conditioning. Blood. 2014 Nov 6;124(19):2937-47. PMCID: PMC4224192.
    11. Lee D, Sykes SM, Kalaitzidis D, Lane AA, Kfoury Y, Raaijmakers MH, Wang YH, Armstrong SA, Scadden DT. Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors. Stem Cell Reports. 2014 Nov 11;3(5):832-40. PMCID: PMC4235746.
    13. Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB (2006). Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Molecular Cell 24(6):841-851. PMCID: PMC1766330.
All publications