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We study two viruses that can infect the human liver. These are known as hepatitis B virus (HBV) and hepatitis delta virus (HDV). Chronic infections can lead to extensive liver damage and a greatly increased risk of proceeding to cancer. One current research interest is to understand how these two viruses are able to enter cells into liver cells. The second, more long-term interest, is to understand how the HDV is able to replicate its ribonucleic acid (RNA) genome.

1. Alves C, Cheng H, Roder H, Taylor J. Intrinsic disorder and oligomerization of the hepatitis delta virus antigen. Virology. 2010, in press.
2. Taylor JM, Pelchat M. Origin of hepatitis δ virus. Future Microbiology. 5: 393-402, 2010. PubMed
3. Taylor JM. Replication of the hepatitis delta virus RNA genome. Adv Virus Res. 2009;74:103-21. PubMed
4. Han Z, Alves C, Gudima S, Taylor J. Intracellular localization of hepatitis delta virus proteins in the presence and absence of viral RNA accumulation. J Virol. 2009;83: 6457-63. PubMed
5. Chai N, Chang H-E, Nicolas E, Jarnik M, Taylor J. Properties of subviral particles of hepatitis B virus. J Virol. 2008 Aug;82(16):7812-7. PubMed
6. Gudima S, He Y, Chai N, Bruss V, Urban S, Mason W, Taylor J. Primary human hepatocytes are susceptible to infection by hepatitis delta virus assembled with envelope proteins of woodchuck hepatitis virus. J Virol. 2008;82: 7276-83. PubMed