Natalia Tulina, PhD
Assistant Research Professor
Office Phone: 215-214-1457
The cell content of organisms changes throughout their lifetimes, cells become physically damaged, accumulate mutations resulting in cell death or relocate within the organism. In order to preserve proper organ function, tissues need to replace these lost cells by generating new ones. This is accomplished by populations of adult stem cells which undergo divisions in response to the decreasing cell supply within a tissue. Rates of stem cell divisions vary from one tissue to another, dependent on factors specific to the tissue as well as regulators that simultaneously affect multiple organs or the organism as a whole. Our laboratory is interested in studying molecular mechanisms that regulate mitotic activity of adult stem cells, using the fruit fly, Drosophila melanogaster, as the model system for our research. In particular, we focus on assessing how wakefulness, sleep, stress and disease may modulate stem cell division.
- Issigonis M, Tulina N, de Cuevas M, Brawley C, Sandler L, Matunis E. JAK-STAT signal inhibition regulates competition in the Drosophila testis stem cell niche. Science. 2009 Oct 2;326(5949):153-6. PubMed
- Terry NA, Tulina N, Matunis E and DiNardo S. Novel regulators revealed by profiling Drosophila testis stem cells within their niche. Dev Biol. 2006 Jun 1;294(1):246-57. Epub 2006 Apr 17. PubMed
- Tulina N.M. Molecular control of spermatogonial stem cell self-renewal by glycoprotein Unpaired, a cytokine homolog, in Drosophila melanogaster. Dokl Biol Sci. 2003 Jan-Feb;388:79-82. PubMed
- Tulina NM and Matunis EL. Jak-Stat signaling maintains germline and somatic stem cell fate during Drosophila spermatogenesis. Science. v.2001;294:2546-2549.