Faculty Summaries
Donghua Yang
Dong-Hua Yang, MD, PhD
Assistant Research Professor
Donghua.yang@fccc.edu
Office Phone: 215-214-3242
Office: P2025B
Lab: P2025

Publications

  • Yang DH, McKee KK, Chen ZL, Mernaugh G, Strickland S, Zent R and Yurchenco PD Renal collecting system growth and function depend upon embryonic gamma1 laminin expresseion. Development, 2011 Oct. 138(20): 4535-44. Epub 2011 Sep.8.
  • Ding PR, Tiwari AK, Ohnumas S, Lee JW, An X, Dai CL, Lu QS, Singh S, Yang DH, Talele TT, Ambudkar SV, Chen ZS The phospodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/p-glycoprotein transtporter. PLoS One 2011 Apr 28:6(4): e19329.
  • Yang D-H, Smith ER, Cai KQ and Xu XX c-fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm development. Dev Dyn 2009 Mar;238(3):514-23.
  • Zhang X, Mernaugh G, Yang DH, Gewin L, Srichai MB, Harris RC, Iturregui JM, Nelson RD, Kohan DE, Abrahamson D, Fässler R, Yurchenco P, Pozzi A, Zent R. Beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development. 2009 Oct;136(19):3357-66.
  • Cai KQ, Capo-Chichi CD, Rula ME, Yang D-H and Xu XX Dynamic GATA6 expression in primitive endoderm formation and maturation in early mouse embryogenesis. Dev Dyn. 2008 Oct;237(10):2820-9.
  • Yang D-H, Cai KQ, Roland IH, Smith ER and Xu XX Disabled-2 is an epithelial surface positioning gene. J Biol Chem. 2007 Apr 27;282(17):13114-22.
  • Rula ME, Cai KQ, Moore R, Yang D-H, Staub CM, Apo-Chichi CD, Jablonski SA, Howe PH, Smith ER and Xu XX Cell autonomous sorting and surface positioning in the formation of primitive endoderm in embryoid bodies. Genesis. 2007 May 15;45(6):327-338.
  • Yang D-H, Z Fazili, E.R. Smith, , Q Cai, A. Klein-Szanto, C. Cohen, IR Horowitz and X.X.Xu Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53 null background. Am. J. Path. 2006, 169:258-267 .
  • Yang D-H and E. G. Moss Temporally regulated expression of Lin-28 in diverse tissue of the developing mouse. Gene Expression Pattern 2003, 3(6): 719-26.
  • Roland IH, Yang WL, Yang D-H , Daly MB, Ozols RF, Hamilton TC, Lynch HT, Godwin AK and XX Xu Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies. Cancer 2003 98 (12): 2607-23.
  • Yang D-H, E.R. Smith, I.H. Roland, Z. Sheng, J.,He, W. D. Martin, J. D. Kambeth, T.H. Hamiton and X.X. Xu Disabled-2 is essential for endodermal cell positioning and structural formation during mouse embryogenesis. Dev. Biol.2002, 251:27-44 .
  • Yang D-H, E.R. Smith, C. Cohen, C. Patriotis, A.K. Godwin, T.C. Hamilton and X.X.Xu Molecular events associated with dysplastic morphological transformation and initiation of ovarian tumorigenicity. Cancer 2002, 94: 2380-2392.
  • Capo-Chichi CD, Smith ER, Yang DH, Roland IH, Vanderveer L, Cohen C, Hamilton TC, Godwin AK, Xu XX. Dynamic alterations of the extracellular environment of ovarian surface epithelial cells in premalignant transformation, tumorigenicity, and metastasis. Cancer. 2002; 95(8):1802-15.
  • Smedberg JL, Smith ER, Capo-Chichi CD, Frolov A, Yang DH, Godwin AK, Xu XX. Ras/MAPK Pathway Confers Basement Membrane Dependence upon Endoderm Differentiation of Embryonic Carcinoma Cells. J Biol Chem. 2002, 277(43):40911-40918.
  • Smith E.R., C.D. Capo-chichi, J. He, J.L. Smedberg, M. E. Rula, D-H Yang, A.H.Prowse, A.K. Godwin, T.C. Hamilton and X.X.Xu Disabled-2 mediates c-Fos suppression and the cell growth regulatory activity of retinoic acid in embryonic carcinoma cells. J. Biol. Chem. 2001, 276: 32094-32100.
  • Yang D-H, Tsuyama S and Murata F The expression of gastric H-K-ATPase mRNA and protein in developing rat fundic gland. Histochem J 2001, 33: 159-166.
  • Yang D-H, Tsuyama S, Hotta K, Katsuyama T and Murata F Expression of N-acetylglucosamine residues in developing rat fundic gland cells. Histochem J 2000, 32(3): 187-193.
  • Murata F, Yang D-H, Tsuyama S and Ohmori J Parietal cells studied by means of electron microscopy, lectin staining, immunohistochemistry and in situ hybridization. Italian J. Anat. Embryo. 1999, 104 suppl.1: 484 .
  • Tsuyama S, Yang D-H, Ohmori J and Murata F Ultracytochemical localization of gastric proton pump by high pressure frozen and freeze substitution method. Italian J. Anat. Embryo. 1999, 104 suppl.1: 721.
  • Yang D-H, Tsuyama S, Ohmori J and Murata F Sulfated glycosaminoglycans of guinea pig neutrophils studied by means of cationic colloidal gold. J Histochem Cytochem 1999, 47(7): 881-887.
  • Yang D-H, Tsuyama S, Ohmori J, Hotta K, Katsuyama T and Murata F Phenotypic immunostaining of mucus-secreting cells of foregut origin. Acta Histochem Cytochem 1999 32(2): 135-140.
  • Ohmori J, Nawa Y, Yang D-H, Tsuyama S and Murata F Keratan sulfate glycosaminoglycans in murine eosinophil-specific granules. J Histochem Cytochem 1999, 47(4): 481-488.
  • Miyauchi M, Tsuyama S, Yang D-H, Ohmori J, Kato K, Nakayama J, Katsuyama T and Murata F Ontogeny of the rat parietal cell: analysis using anti-parietal cell antibody and transmission electron microscopy. Acta Anat Nippon 1999, 74(2): 197-207.
  • Yang D-H, Tsuyama S, Ohmori J and Murata F Sulfated glycosaminoglycans of guinea pig eosinophils studied by means of cationic colloidal gold. Histochem J. 1998,30: 687-692.
  • Yang D-H, Tsuyama S, Ohmori J and Murata F Sulfated glycosaminoglycans of guinea pig basophils studied by means of cationic colloidal gold. Histochem Cell Biol. 1998, 109: 189-194.
  • Ge Y-B, Ohmori J, Tsuyama S, Yang D-H, Kato K, Miyauchi M and Murata F Immunocytochemistry and in situ hybridization studies of pepsinogen C producing cells in developing rat fundic gland. Cell Tiss. Res. 1998, 293: 121-131.
  • Yang D-H, Tsuyama S, Ge Y-B, Ohmori J, Wakamatsu D and Murata F Proliferation and migration kinetics of stem cells in the rat fundic gland. Histol. Histopath. 1997, 12: 717-728.
  • Ge Y-B, Yang D-H, Ohmori J, Tsuyama S, Kim B-S, Kim J-B and Murata F Cationic colloidal gold staining of acidic glycoconjugates in mouse Paneth cells. Arch Histol Cytol 1997, 60: 133-142.
  • Ohmori J, Tomita M, Nawa Y, Ge Y-B, Yang D-H, Tsuyama S and Murata F Eosinophil peroxidase deficiency in human and mice. Acta Histochem Cytochem 1997, 30: 231-236.
  • Yang D-H, Kasamo H, Miyauchi M, Tsuyama S, and Murata F  Ontogeny of sulfated glycoconjugate producing cells in the rat fundic gland. Histochem J 1996, 28:33-43.
  • Kasamo H, Yang D-H, Tsuyama S, Ge Y-B and Murata F Ontogeny of proliferative cells in the rat fundic gland. Acta Anat Nippon 1996, 71: 20-29.
  • Zen Z-L, Wang Z-X, Yang D-H and Murata F Observation of lectin binding sites in human fetal esophageal epithelium. Guangdong Anatomical Bulletin 1995, 17: 47-49.
  • Tsuyama S, Yang D-H, Kanae T, Kasamo H and Murata F Immunoelectron microscopic labeling of digestive tract stem cells by means of BrdU antibody. Acta Histochem Cytochem 1994, 27: 339-345.
  • Murata F, Tsuyama S, Kanae T, Ihida K and Yang D-H  Sites of glycosylation observed by post-embedding and pre-embedding lectin staining. Acta Histochem Cytochem 1994, 27: 607-612.
  • Yang D-H The characteristics of lipolytic activity of Staphylococcus Aureus on various agar culture. Food Inspec. Techniq. 1992, 3: 29-30.
  • Yao YZ and Yang D-H Life cycle of membranous receptors. Prog. Physiol. Sci. 1990, 21(3): 242-246.
  • Yang D-H Transportation of intraventricular amines and its possible mechanism. Proccedings of Sun Yat-Sen University of Medical Sciences. 1990, 139-145.
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