Zeng-jie Yang, MD, PhD
Office Phone: 215-214-1545
Medulloblastoma is the most common malignant brain tumor in children, and also occurs in adults. Despite significant progress in development of treatments for this cancer, the mortality rate of medulloblastoma is still very high. Our research seeks to elucidate the mechanisms of medulloblastoma initiation and progression, with the aim of translating the findings into improved strategies for the treatment of medulloblastoma.
To study the basis of medulloblastoma formation, we first focus on the tumor cell itself, to define what genetic and/or epigenetic events could convert a normal cell into a tumor cell. We are also examining the functions of tumor-supporting cells (the tumor stroma, and other constituents of the tumor microenvironment) in medulloblstoma formation. We hope to find a more effective way to control medulloblastoma growth, through targeting both tumor cells and their supporting stroma.