Tim J Yen, PhD

Senior Member
Basic Science Division

Timothy.Yen@fccc.edu
Phone: 215-728-2590

Recent Publications

In Press

Feng, J., Huang, H., Yen, T.J. CENP-F is a novel microtubule binding protein that also contributes to the mitotic checkpoint. Chromosoma (in press).

2005

Chan, G.K., Liu, S.T., Yen, T.J.Kinetochore structure and function. Trends Cell Biol. 15:589-598, 2005.

Kao, G., Yen, T.J. Kinetochore function, chromosome segregation and the spindle assembly checkpoint. In Genome Instability in Cancer Development. Advances in Experimental Medicine and Biology, edited by E.A. Nigg. Springer, vol. 570, pp.477- 499, 2005.

Mollinari, C., Kleman, J.-P., Saoudi, Y., Jablonski, S., Perard, J., Yen, T.J., Margolis, R. Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not. Mol. Biol. Cell. 16:1043-1055, 2005.

2004

Garcia-Saez, I., Yen, T.J., Wade, R.H., Rozielski, F. Crystal structure of the motor domain of the human kinetochore protein CENP-E. J. Mol. Biol. 340:1107-1116, 2004.

Joseph J, Liu ST, Jablonski SA, Yen TJ, Dasso M. The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo. Curr Biol. 14:611-7, 2004.

2003

Daniel, R., Kao, G., Taganov, K., Greger, J., Favorova, O., Merkel, G., Yen, T.J., Katz, R.A., Skalka, A.M. Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response. Proc. Natl. Acad. Sci. U. S. A. 100:4778-4783, 2003.

Fletcher, L., Yen, T.J., Muschel, R.J. DNA damage in HeLa cells induced arrest at a discrete point in G2 as defined by CENP-F localization. Radiat. Res. 159:604-611, 2003.

Kao, G.D., McKenna, W.G., Guenther, M.G., Muschel, R.J., Lazar, M.A., Yen, T.J. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. J. Cell. Biol. 160:1017-1027, 2003.

Liu, S.T., Hittle, J.C., Lees, E., Yen, T.J. Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores. Mol. Biol. Cell. 14:1638-1651, 2003.

Liu, S.T., Hittle, J.C., Jablonski, S.A., Campbell, M.S., Yoda, K., Yen, T.J. Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis. Nat. Cell Biol. 5:341-345, 2003.

Williams, B.C., Li, Z., Liu, S., Williams, E.V., Leung, G., Yen, T.J., Goldberg, M.L. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. Mol. Biol. Cell. 14:1379-1391, 2003.

2002

Chaturvedi, P., Sudakin, V., Bobiak, M.L., Fisher, P.W., Mattern, M.R., Jablonski, S.A., Hurle, M.R., Zhu, Y., Yen, T.J., Zhou, B.B. Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity. Cancer Res. 62:1797-1801, 2002.

Guenther, M.G., Yu, J., Kao G.D., Yen T.J., Lazar M.A. Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev. 16:3130-3135, 2002.

Nelson DM, Ye X, Hall C, Santos H, Ma T, Kao GD, Yen T.J., Harper JW, Adams PD. Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity. Mol. Cell. Biol. 22:7459-7472, 2002.

Parra, M.T., Page, J., Yen, T.J., He, D., Valdeolmillos, A., Rufas, J.S., Suja, J.A. Expression and behaviour of CENP-E at kinetochores during mouse spermatogenesis. Chromosoma 111:53-61, 2002.

The information in the below link is obtained from Pubmed.