Research at Fox Chase »Postdoctoral Research Program »Fellowships and Openings

Lecture 1: "Principles of Chemoprevention" by Paul F. Engstrom, MD

Topics: Classification and mechanism of action of agents; surrogate endpoint biomarkers; intraepithelial neoplasia; field carcinogenesis; and a review of published phase II and phase III chemoprevention trials.

Lecture 2: "Design and Implementation of a Phase I-II Chemoprevention Protocol" by Paul F. Engstrom, MD; David Weinberg, MD, MSc; Michael Unger, MD

Topics: Selection of agent and suitable endpoints; selection and recruitment of subjects; statistics; data analysis; and results analysis. Ongoing and completed studies will serve as examples for discussion.

Learning Objectives: At the completion of this set of presentations, the trainee will be able to identify chemoprevention agents and different functional classes, understand principles of chemoprevention research, know results of successful (positive) chemoprevention trials, be able to critically evaluate phase II chemoprevention protocols, and identify strengths and weaknesses of chemoprevention research protocols.