2000 Scientific Report

Basic Science
Institute for Cancer Research
Forty-Fifth Scientific Report

Biomolecular Structure and Function

• Structural Studies in Enzyme Mechanisms and in Chemical Carcinogenesis and Mutagenesis
  Jenny Pickworth Glusker, DPhil, DSc
• Computational Structural Biology: Structure Prediction, Analysis, and Bioinformatics
  Roland L Dunbrack, Jr, PhD
• How Enzymes Work
  Eileen K Jaffe, PhD
• Structure and Function of Enzymes
  George D Markham, PhD
• Protein Folding, Structure and Function
  Heinrich Roder, PhD
• DNA Repair and Mutation Detection
  Anthony T Yeung, PhD

Cellular and Developmental Biology

• Gene Regulatory Mechanisms and Cell Differentiation
  Kenneth S Zaret, PhD
• GATA-4/5/6 Gene Regulation and Heart Development
  John Burch, PhD
• Human/Yeast Complementation Approaches to the Study of Oncogenic Signalling
  Erica A Golemis, PhD
• Mitotic Chromosome Structure and Segregation in Yeast
  Vincent Guacci, PhD
• Melanoma Progression and Therapy in Transgenic Mouse Models
  Beatrice Mintz, PhD
• Developmental Timing and Translational Regulation
  Eric G. Moss, PhD
• Genetics of Pigmentation:Endothelin-B Receptor Signaling in Melanocyte Development
  Myung K Shin, PhD
• Genetic Control of Meiotic Development in Yeast
  Randy Strich, PhD
• Functional Characterization of Werner, Bloom, and Rothmond-Thompson Syndrome
  Proteins in Xenopus Egg Extracts
  Hong Yan, PhD
• Cellular Mechanisms that Maintain Human Genome Stability
  Tim J Yen, PhD

Immunobiology

• Fetal and Adult B Lymphocyte Differentiation
  Richard R Hardy, PhD
• Recombination and Expression of Immunoglobulin Genes
  Melvin J Bosma, PhD
• Signal Transduction by Receptors on Human Natural Killer Cells
  Kerry S Campbell, PhD
• Self-Antigen and Immune System Development
  Kyoko Hayakawa, MD, PhD
• T Cell Development and Signal Transduction
  Dietmar J Kappes, PhD
• Control of T Lymphocyte Development by Antigen Receptors
  David L Wiest, PhD

Molecular Oncology

• Role of Protein Phosphorylation in Adhesion-Dependent Signaling Pathways
  Jonathan Chernoff, MD, PhD
• Regulation of Cell Division
  Peter D Adams, PhD
• Molecular Mechanisms Governing Eukaryotic DNA Replication and Cell Cycle Progression
  Thomas R Coleman, PhD

Virology

• Hepatitis Delta Virus
  John M Taylor, PhD
• Hepatitis Viruses and Liver Cancer
  William S Mason, PhD
• Pathogenesis of Neurotropic Viral Infections
  Glenn F Rall, PhD
• Replication and Pathogenesis of Hepatitis Viruses
  Christoph Seeger, PhD
• Mechanisms of MHC Class I Antigen Presentation and Cytotoxic T Lymphocyte Immunity
  Luis J Sigal, DVM, PhD
• Molecular Biology of Retroviruses
  Anna Marie Skalka, PhD