Technology Licensing

The technologies listed below are available for licensing. Technologies are listed by type: Therapeutic Targets; Research Methods, Screens and Assays; Reagents; and Software.

Contact us by email, fax or by phone for licensing information.

Proton Beam Radiotherapy

• Particle Selection, Beam Monitoring and System Design for Laser-Accelerated Ion/Ion Beams for Radiotherapy (#03-12) - This invention provides significant advances in proton beam radiotherapy. Building an Enormous Cancer Killer (PDF, requires Adobe Acrobat^®)
  (Philadelphia Inquirer, 10-10-2006)

Therapeutic Antibodies

• Rational Antibody Design

Therapeutics and Discovery Targets

• Cancer

  • Combination Therapy for the Treatment of Cancer
  • Diagnostic Method for Early Pancreatic Cancer Detection
  • HEF1/Cas-L, A Novel Signal Transduction Molecule Associated with Cell Motility, Growth, Apoptosis and Oncogenic Transformation
  • Human BUB Genes: Mitotic Checkpoint Kinases
  • Identification of Putative Interacting Components in Complex Pathways
  • Markers for Early Diagnosis of Cancer
  • Markers for Renal Cancer Diagnosis and Prognosis
  • MED1 (MBD4), A Novel Gene Associated with Cancer Drug Resistance
  • Method for the Treatment or Prophylaxis of LAM
  • Novel Methods for Inhibiting Angiogenesis
  • Nucleic Acid Cleavage Assay for Transposase/Integrase Protein Superfamily
  • OVCA1 and OVCA2 Tumor Suppressor Genes
  • P53-Dependent Asymmetric Cell Division - A Novel Screen for Growth Regulatory Compounds
  • Pregnancy-Associated Genetic Signatures in the Human Breast
  • Rational Antibody Design
  • Synergistic Cytotoxic Effect of Combined Nucleoside/Base Analogs
  • Target Therapy for Ovarian Cancer
  • Tumor-Specific Antisense Therapy to Inhibit Bcl-2 Expression and Induce Apoptosis for Treatment of Non-Hodgkin's Lymphoma

• Antibiotics, Industrial Chemicals and Herbicides

  • A Novel Specific Inhibitor of Tetrapyrrole Biosynthesis in Plants
  • Porphobilinogen Synthase: A Novel Specific Inhibitor of Tetrapyrrole Biosynthesis in Plants

• HIV/AIDS

  • ATR Kinase - A Novel Target for Anti-Retroviral Drug Discover

• Cancer, HIV, Urology

  • MRP-Related Transporter Genes Involved in Erectile Dysfunction Signaling Pathway, Drug Resistance and Connective Tissue Homeostasis

Research Methods, Screens, and Assays

• Advanced Method for Generating Gene- or Pathway-Targeted Functional Probe Set
• ELISA Assay for the Detection of Ectromelia and Vaccinia Virus Antibodies in Mice, using Recombinant Viral Proteins
• The Two Hybrid Dual Bait System: An Improved Two Hybrid System for the Detection of Protein-Protein Interactions
• A Yeast Bioassay System for the Identification of Compounds That Can Lower Plasma Homocysteine Levels
• P53-Dependent Asymmetric Cell Division - A Novel Screen for Growth Regulatory Compounds
• Methods of Screening for Inhibitors of Autoinhibited Proteins
• A Novel Tumor Cell Marker for use in Evaluating Cancer Therapeutics
• Cenp-F, A Novel Cell-Cycle Specific Protein That Is Involved in Chromosomal Segregation During Mitosis

• Animal Models

  • Appl1 Knockout Mouse
  • MISIIR-TAg Mouse - A New Model of Epithelial Ovarian Cancer
  • TetOp16 Transgenic Mouse Model for Cancer and Cell Proliferation Research
  • Apc^+/Min-FCCC Mouse: a Model for Colorectal Cancer

• Vaccines

  • Use of secreted/cell-bound poxvirus proteins (SPVP) and use thereof as vaccines and antiviral agents - Dr. Luis Sigal, DVM, PhD

Vectors, Antibodies, Reagents and Cell Lines

• Vectors

  • PGLS20 vector: A novel dual purpose vector for protein expression in E.coli and S.cerevisiae (PDF, requires Adobe Acrobat^®)
  • A Mutated Human Cytomegalovirus Expression Vector With Enhanced Ability to Express Foreign Genes
  • A Chimeric Integrase-Containing Expression Vector for Promoting Targeted Integration of Foreign DNA into a Host Genome

• Polyclonal Antibodies

  • The following polyclonal antibodies are available for licensing:

    • Rabbit polyclonal antibody to HEPL, a novel Cas family protein
    • Anti-murine Fibroblast Activation Protein (FAP) Polyclonal Antisera

• Monoclonal Antibodies

  • The following monoclonal antibodies are available for licensing:

    • Murine Monoclonal Antibodies to Mad1, and Mad2—Mitotic Checkpoint Proteins
    • Monoclonal Antibodies against human ASF1a, a histone chaperone and regulator of cell proliferation
    • Antibodies against Human CENP-E

• Endonucleases

  • MED1 Glycosylase, a Tool for Detection of transition SNPs at CpG sites (CT-SNPs)

• Cell Lines

  • Murine and Human Non-Hepatic Cell Lines that support Hepatitis C Virus replication
  • Scid.adh, A Thymic Cell Line That Mimics T-Cell Development In Vitro
  • HEF1/Cas-L, A Novel Signal Transduction Molecule Associated with Cell Motility, Growth, Apoptosis and Oncogenic Transformation

• Medical Devices

  • Endoscope Handle Manipulator
  • The Easy Attach
  • Easy Positioning Belt
  • Scent-releasing Respiratory Mask

Software

• Array Explorer™ — Image-Processing Software for cDNA Microarray Analysis