Technology Licensing

Animal Models

• Appl1 Knockout Mouse
• MISIIR-TAg Mouse - A New Model of Epithelial Ovarian Cancer
• TetOp16 Transgenic Mouse Model for Cancer and Cell Proliferation Research
• Apc^+/Min-FCCC Mouse: a Model for Colorectal Cancer

Diagnostics

• Cancer

  • Diagnostic Method for Early Pancreatic Cancer Detection
  • Markers for Early Diagnosis of Cancer
  • Markers for Renal Cancer Diagnosis and Prognosis

Medical Devices

• Endoscope Handle Manipulator
• The Easy Attach
• Easy Positioning Belt
• Scent-releasing Respiratory Mask

Research Materials

• Vectors

  • PGLS20 vector: A novel dual purpose vector for protein expression in E.coli and S.cerevisiae (PDF, requires Adobe Acrobat^®)
  • A Mutated Human Cytomegalovirus Expression Vector With Enhanced Ability to Express Foreign Genes
  • A Chimeric Integrase-Containing Expression Vector for Promoting Targeted Integration of Foreign DNA into a Host Genome

• Polyclonal Antibodies

  • Polyclonal Antibodies: FAP, phospho-PIX
  • Polyclonal Antibodies: HEPL, ATM

• Monoclonal Antibodies

  • Monoclonal Antibodies: ASF1a, HEF1/NEDD9/Cas-L, hBUBs
  • Monoclonal Antibodies: CENP-E
  • Monoclonal Antibodies: Mad1, Mad2, HIRA

• Endonucleases

  • MED1 Glycosylase, a Tool for Detection of transition SNPs at CpG sites (CT-SNPs)

• Cell Lines

  • Murine and Human Non-Hepatic Cell Lines that support Hepatitis C Virus replication
  • Scid.adh, A Thymic Cell Line That Mimics T-Cell Development In Vitro
  • HEF1/Cas-L, A Novel Signal Transduction Molecule Associated with Cell Motility, Growth, Apoptosis and Oncogenic Transformation

Research Methods, Screens, and Assays

• Advanced Method for Generating Gene- or Pathway-Targeted Functional Probe Set
• ELISA Assay for the Detection of Ectromelia and Vaccinia Virus Antibodies in Mice, using Recombinant Viral Proteins
• The Two Hybrid Dual Bait System: An Improved Two Hybrid System for the Detection of Protein-Protein Interactions
• A Yeast Bioassay System for the Identification of Compounds That Can Lower Plasma Homocysteine Levels
• P53-Dependent Asymmetric Cell Division - A Novel Screen for Growth Regulatory Compounds
• Methods of Screening for Inhibitors of Autoinhibited Proteins
• A Novel Tumor Cell Marker for use in Evaluating Cancer Therapeutics
• Cenp-F, A Novel Cell-Cycle Specific Protein That Is Involved in Chromosomal Segregation During Mitosis

Software

• Array Explorer™ — Image-Processing Software for cDNA Microarray Analysis

Therapeutics

• Cancer Therapeutics and Discovery Targets

  • Combination Therapy for the Treatment of Cancer
  • HEF1/Cas-L, A Novel Signal Transduction Molecule Associated with Cell Motility, Growth, Apoptosis and Oncogenic Transformation
  • Human BUB Genes: Mitotic Checkpoint Kinases
  • Identification of Putative Interacting Components in Complex Pathways
  • MED1 (MBD4), A Novel Gene Associated with Cancer Drug Resistance
  • Method for the Treatment or Prophylaxis of LAM
  • Novel Methods for Inhibiting Angiogenesis
  • Nucleic Acid Cleavage Assay for Transposase/Integrase Protein Superfamily
  • OVCA1 and OVCA2 Tumor Suppressor Genes
  • P53-Dependent Asymmetric Cell Division - A Novel Screen for Growth Regulatory Compounds
  • Pregnancy-Associated Genetic Signatures in the Human Breast
  • Rational Antibody Design
  • Synergistic Cytotoxic Effect of Combined Nucleoside/Base Analogs
  • Target Therapy for Ovarian Cancer
  • Tumor-Specific Antisense Therapy to Inhibit Bcl-2 Expression and Induce Apoptosis for Treatment of Non-Hodgkin's Lymphoma
  • MRP-Related Transporter Genes Involved in Erectile Dysfunction Signaling Pathway, Drug Resistance and Connective Tissue Homeostasis

• Proton Beam Radiotherapy

  • Building an Enormous Cancer Killer (PDF, requires Adobe Acrobat^®)

• Therapeutic Antibodies

  • Rational Antibody Design

• Antibiotics, Industrial Chemicals and Herbicides

  • A Novel Specific Inhibitor of Tetrapyrrole Biosynthesis in Plants
  • Porphobilinogen Synthase: A Novel Specific Inhibitor of Tetrapyrrole Biosynthesis in Plants

• HIV/AIDS

  • ATR Kinase - A Novel Target for Anti-Retroviral Drug Discover

• Urology

  • MRP-Related Transporter Genes Involved in Erectile Dysfunction Signaling Pathway, Drug Resistance and Connective Tissue Homeostasis

Vaccines

• Use of secreted/cell-bound poxvirus proteins (SPVP) and use thereof as vaccines and antiviral agents - Dr. Luis Sigal, DVM, PhD