Fox Chase Cancer Center
Research and Technology Symposium

Tuesday May 20
8:30am – 5:30pm
The Academy of Natural Sciences
1900 Benjamin Franklin Parkway
Philadelphia

« About the Symposium « Free Registration Required

Research topics to be presented during the Symposium include:

• cell signaling modification in tumors progression resulting from metastasis and drug resistance;
  
• exploitation of engineered antibody fragments to detect and treat solid tumors;
  
• characterization of the genetic changes in cancer cells;
  
• evaluation of normal gene function and pathogenesis of cancer cells to assess cancer prevention, diagnosis, and treatment;
  
• biological relevance, involvement, and regulation of signaling pathways that operate through Rho proteins;
  
• involvement of protein phosphorylation in governing the proliferative and morphologic transformation of cancer;
  
• development of new cancer treatments with fewer side effects, with an emphasis on gastrointestinal, breast and genitourinary cancers;
  
• signal transduction crosstalk between Killer Cell Inhibitory Receptors (KIR) and KIR2DL4, and involvement of KIR2DL4 in natural killer cell responses toward tumors and virus-infected cells;
  
• investigation of basic paths of viral infection of the CNS (access, replication, progress, and role of the immune response) and their consequences on the host;
  
• elaboration of computational structural biology models, such as homology modeling, fold recognition, molecular dynamics simulations, statistical analysis, and bioinformatics, to study DNA repair, membrane proteins, proteases and other peptide-binding protein families;
  
• refinement and analysis of mouse models of epithelial ovarian cancer to identify and study the underlying genetic causes of tumor initiation and progression;
  
• involvement of gene activation and cell differentiation in mammalian development;
  
• establishment of preclinical programs to develop efficacious regimens for the clinical prevention of colon, lung and oral cancer;
  
• evaluation of biological implications of recurrent genomic alterations occuring in malginant mesotheliomas;
  
• analysis of intracellular functions of two proteins encoded by the TSC1 and TSC2 gene, responsible for causing the tuberous sclerosis complex disease;
  
• investigation of pre-T cell antigen receptor (TCR) activation and its development into the mature TCR complex;
  
• overview of the Fox Chase phase I/II clinical research capabilities and programs.

A final networking reception will take place to meet with Business Development colleagues in other Companies, investigators and clinical scientists, in the beautiful setting of The Academy of Natural Sciences in downtown Philadelphia. Map and Directions

For more information, contact the Fox Chase Office of Business Development.

- Free Registration Required -