David Wiest, PhD
- Vice President, Deputy Chief Scientific Officer
- Co-Leader, Immune Cell Development and Host Defense
- Co-Leader, Blood Cell Development and Cancer Keystone
As Deputy Chief Scientific Officer, Dr. Wiest works with Dr. Chernoff to plan the future of research at Fox Chase.
Dr. David L. Wiest, an immunologist, is a professor of the scientific staff at Fox Chase Cancer Center. In addition to his role as co-leader of the Keystone Program in Blood Stems and Cancer, he is also co-leader of the Immune Cell development and Host Defense program.
His laboratory studies aspects of the body's chemical signaling network, which guides cells through their growth stages and initiates or halts various activities. Wiest's research focuses on the development and function of T-cell receptors, which enable those immune cells recognize and lock onto viruses, bacteria and other invaders. T-cells coordinate the body's immune response. An assembly of proteins called the T-cell antigen receptor (TCR) complex not only controls the behavior of mature T cells but also guides their development in the thymus.
Wiest earned his B.S. in Microbiology at Pennsylvania State University, where he was elected to Phi Beta Kappa, and his Ph.D. in immunology at Duke University, Where he held a Merit Scholarship and received Duke's Norman F. Conant Research Award. He then completed a four-year fellowship at the National Caner Institute's experimental immunology branch before coming to Fox Chase in 1995.