Table of Services

Histopathology Publications

2012

  • Rizzolio F. , Lucchetti C. , Caligiuri I. , Marchesi I. Caputo M., Klein-Szanto AJ, Bagella L., Castronovo M. and Giordano A. Retinoblastoma tumor suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Cell Death & Differentiation 19:1152-1161, 2012. PMC3374078
  • Pero R., Palmieri D., Angrisano T., Valentino T., Federico A., Franco R., Lembo F., Klein-Szanto A.J., Del Vecchio L., Montanaro D., Keller S., Arra C., Papadopoulou V., Wagner S.D., Croce C., Fusco A., Chiariotti L., and Fedele M. PATZ interacts with the human oncogene BCL6 and is required for its negative autoregulation. J. Biol. Chem. 287:18308-18317, 2012.
  • Fu J., Bassi D.E., Jirong Zhang J., Li T., Nicolas E. and Klein-Szanto A.J.P. Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth. Neoplasia 14: 271–282, 2012. PMC3349254.
  • Bassi D.E., Fu J., Zhang J., and Klein-Szanto A.J. The Role of Proprotein Convertases in Animal Models of Skin Carcinogenesis. Colloquium Series on Protein Activation and Cancer, A.M. Khatib (Editor), San Rafael (CA): Morgan & Claypool Life Sciences; 2012. (in press).
  • Klein-Szanto A.J., Zhang J., and Bassi D.E. Proprotein Convertases in gynecological cancers. Colloquium Series on Protein Activation and Cancer, A.M. Khatib (Editor), San Rafael (CA): Morgan & Claypool Life Sciences; 2012.
  • Naganuma S.,. Whelan K., Natsuizaka M., Kagawa S., Kinugasa H., Chang S , Subramanian H., Rhoades B., Ohashi S., Itoh H., Herlyn M., Diehl J., Gimotty P., Klein-Szanto A.J., Nakagawa H., Genetic Notch inhibition reveals cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma. Am. J. Cancer Res. 2:459-475, 2012.
  • Rizzolio F, Caligiuri I, Lucchetti C, Fratamico R, Tomei V, Gallo G, Agelan A, Ferrari G, Toffoli G, Klein-Szanto AJ, Giordano A. Dissecting Pin1 and phospho-pRb regulation. J Cell Physiol. (in press).
  • Morris J, Sul J-Y, Kim M-S, Klein-Szanto A J, Schochet T, Rustgi, A, Eberwine JH Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma. Human Pathol. (in press).

2011

  • Shatalova E., Klein-Szanto A., Devarajan K., Cukierman E., and Clapper M.. Estrogen and Cytochrome P450 1B1 Contribute to Both Early- and Late-Stage Head and Neck. Cancer Prevention Res. 4:107-115, 2011. PMC3043603
  • Makhlin I, Zhang J, Long CJ, Devarajan K, Zhou Y, Klein-Szanto AJ, Huang M, Chernoff J, Boorjian SA. The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers. BJU Int. 108(2B):E84-E90, 2011. PMC3116980
  • Fedele M, Visone R, De Martino I, Palmieri D, Valentino T, Esposito F, Klein-Szanto A, Arra C, Ciarmiello A, Croce CM, Fusco A. Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice. Eur. J. Cancer 47:470-478, 2011.
  • Stephen Rudnick, Jianlong Lou, Calvin Shaller, Yong Tang, Andres Klein-Szanto, Louis Weiner, James Marks, and Gregory Adams Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors. Cancer Res. 71:2250-9, 2011. PMC3077882
  • Frank AK, Leu JI, Zhou Y, Devarajan K, Nedelko T, Klein-Szanto A, Hollstein M, Murphy ME. The codon 72 polymorphism of p53 regulates interaction with NF-kB and transactivation of genes involved in immunity and inflammation. Mol.Cell Biol. 31:1201-1213, 2011. PMC3038344
  • Stairs, D.B.; Bayne L.; Rhoades B.; Vega M.E.; Waldron T., Kalabis J., Klein-Szanto, A.J. ; Lee S., Katz, J.Diehl A, Reynolds A. , Vonderheide R.; Rustgi A.K. Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a bone fide tumor suppressor. Cancer Cell 19, 470–483, 2011. PMC3077713
  • Altomare DA, Menges CW, Xu J, Pei J, Zhang L, Tadevosyan A., Neumann-Domer E., Liu Z., Carbone M., Chudoba I., Klein-Szanto A.J., Testa J.R. Losses of Both Products of the Cdkn2a/Arf Locus Contribute to Asbestos-Induced Mesothelioma Development and Cooperate to Accelerate Tumorigenesis. PLoS ONE 6(4): e18828. doi:10.1371/journal.pone.0018828, 2011. PMC3079727
  • Hopper-Borge E.A., Churchill T., Paulose C., Nicolas E., J.Jacobs, Ngo O, Kuang Y., Grinberg A., Westphal H., Chen Z., Klein-Szanto A.J., Belinsky M., and Kruh G.D. Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10−/− Mice. Cancer Res. 71:3649-3657, 2011. PMC3096848
  • Cortellino S., Xu J., Sannai M., Moore R., Caretti E., Cigliano A., Le Coz M., Devarajan K. Wessels A., Soprano D., Abramowitz L., Bartolomei M., Rambow F., Bassi M., Bruno T., Fanciulli M., Renner C., Klein-Szanto A.J., Matsumoto Y., KobiD., Davidson I., Alberti C., Larue L., and Bellacosa A. Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair. Cell 146: 67-79, 2011. PMC3230223
  • Goetz JG; Minguet S.; Navarro-LeridaI.; Lazcano J.J.; Samaniego R. ; Calvo E.; Tello M.; Osteso-Ibanez T.; Pellinen T.; Echarri A.; Klein-Szanto A.J.; Garcia R.; Keely P.; Sanchez-Mateos P.; Cukierman E.; Del Pozo M.A. Regulation of the biomechanical properties of the tumor microenvironment by stromal Caveolin-1 promotes invasion. Cell 146:148-163, 2011. PMC3244213
  • Watts J.A., Zhang C., Klein-Szanto A.J., Jay D Kormish J.D., Fu J., Zhang M.K., and Zaret K.S. Study of FoxA Pioneer Factor at Silent Genes Reveals Rfx-Repressed Enhancer at Cdx2 and a Potential Indicator of Esophageal Adenocarcinoma Development. PLoS Genetics 7(9): e1002277, 2011. PMC3174211
  • Ohashi S, Natsuizaka M, Naganuma S, Kagawa S, Kimura S, Itoh H, Kalman RA, Nakagawa M, Darling DS, Basu D, Gimotty PA, Klein-Szanto AJ, Diehl JA, Herlyn M, Nakagawa H. A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT competent cells that express the ZEB transcription factors. Cancer Res. 71:6836-6847, 2011. PMC3206139.

2010

  • Singh MK, Izumchenko E, Klein-Szanto AJ, Egleston BL, Wolfson M, and Golemis EA. Enhanced Genetic Instability and Dasatinib Sensitivity in Mammary Tumor Cells Lacking Nedd9. Cancer Res. 2010;70:8907-8916. PMC2970659.
  • Sosa MS, Yang C, Lopez-Haber C, Lemmon M, Benovic M, Klein-Szanto A, Yagi H, Gutkind JS, Lefebvre C, Parsons RE, and Kazanietz MG. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Molecular Cell. 2010;40:877-892.
  • Quinn BA, Xiao F, Bickel L, Martin L, Hua X, Klein-Szanto A, and Connolly DC. Development of a syngeneic mouse model of epithelial ovarian cancer. J. Ovarian Res. 2010;3:24. PMC2974672.
  • Tetreault MP, Wang ML, Yang Y, Travis J, Yu QC, Klein-Szanto AJ, Katz JP. Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice. Gastroenterology. 2010.
  • Altomare DA, Zhang L, Deng J, Di Cristofano A, Klein-Szanto AJ, Kumar R, Testa JR. GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt. Clin Cancer Res. 2010;16:486-96.
  • Bassi DE, Zhang J, Cenna J, Litwin S, Cukierman E, and Klein-Szanto AJ. Proprotein Convertase Inhibition Results in Decreased Skin Cell Proliferation,Tumorigenesis, and Metastasis. Neoplasia. 2010;2:516-526. PMC2907578
  • Fu J, Jin F, Zhang J, Fong K, Bassi D, Lopez De Cicco R, Ramaraju D, Braunewell K-H, Conti C, Benavides F, and Klein-Szanto AJ. VILIP-1 Expression In Vivo Results in Decreased Mouse Skin Keratinocyte Proliferation and Tumor Development. PLoS One 5 (4): e10196, 2010. PMC2855367
  • Grugan KD, Miller CG, Yao Y, Michaylira CZ, Ohashi S, Klein-Szanto AJ, Diehl J A, Herlyn M, Han M, Nakagawa H, Rustgi AK. Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion. Proceed. National Acad. Sciences (USA), 2010;107:11026-31. PMC2890722

2009

  • Mabuchi S, Kawase C, Altomare DA, Morishige K, Sawada K, Nishio Y, Yamoto M, Klein-Szanto AJ, Schilder RJ, Ohmichi M, Testa JR, Kimura T.  mTOR is a promising target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary.  Clin Cancer Res. 2009;15:5404-13.
  • Kadariya Y, Yin B, Tang B, Shinton S, Quinlivan E, Hua X, Klein-Szanto A, Al-Saleem T, Bassing C, Hardy R, Kruger WD. Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma. Cancer Res. 2009;69:5961-9.
  • Izumchenko E, Singh M, Plotnikova O, Tikhmyanova N, Little J, Serebriiskii I, Seo S, Kurokawa M, Egleston B, Klein-Szanto A, Pugacheva E, Hardy R, Wolfson M, Connolly D, Golemis EA. NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 2009;69:7198-206.
  • Gumireddy K, Li A, Gimotty P, Klein-Szanto AJ, Showe L, Katsaros D, Coukos G, Zhang L, Huang Q. KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat Cell Biol. 2009;11:1297-1304.
  • Gupta S, Kühnisch J, Mustafa A, Lhotak S, Schlachterman A, Slifkef MJ, Klein-Szanto A, High KA, Austin RC, Kruger WD. Mouse models of cystathionine {beta}-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia. FASEB J. 2009;23:883-93.
  • Hartman T, Nicolas E, Klein-Szanto AJ, Al-Saleem T, Cash T, Simon M, Henske EP. The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis. Oncogene. 2009;28:1594-1604.

2008

  • Schilder R, Sill M, Lee R, Shaw T, Senterman M, Klein-Szanto A, Miner Z, Vanderhyden B. A Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: A Gynecologic Oncology Group study. J Clin Oncol. 2008’26:3418-3425. Accepted prior to April 7, 2008
  • Lioni M, Kazuhiro N, Synder A, Klein-Szanto A, Diehl JA, Rustgi AK, Herlyn M, Smalley K. Bortezomib-induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 MAPK pathway. Mol Cancer Ther. 2008;7:2866-75.
  • Lewis-Wambi JS, Kim HR, Wambi C, Patel R, Pyle JR, Klein-Szanto AJ, Jordan VC. Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis. Breast Cancer Res. 10:R104, 2008.
  • Huang Q, Gumireddy K, Schrier M, le Sage C, Nagel R, Nair S, Egan D, Li A, Huang G, Klein-Szanto A, Gimotty P, Katsaros D, Coukos G, Zhang L, Puré E, Agami R. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol. 2008;10:202-10. Accepted prior to April 7, 2008
  • Finnberg N, Klein-Szanto AJP, El-Deiry W. TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. J Clin Invest. 2008;118:111-123.
  • Fang M, Lanier LL, Sigal LJ.  A role for NKG2D in NK cell-mediated resistance to poxvirus disease.  PLoS Pathog. 4:e30, 2008.
  • Fu J, Fong K, Bellacosa A, Ross E, Apostolou S, Bassi D, Jin F, Zhang J, Cairns P, Ibañez de Caceres I, Braunewell K, Klein-Szanto AJ. VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival. PLoS ONE 3:e1698, 2008
  • Okawa T, Michaylira C, Nakagawa H, Andl C, Stairs D, Johnstone C, Klein-Szanto AJ, El‑Deiry W, Cukierman E, Herlyn M, Rustgi AK. The functional interplay between EGFR overexpression, hTERT activation and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induce tumor development, invasion and differentiation. Genes Dev. 2008;21:2788-803.
  • Quiros RM, Valianou M, Kwon Y, Brown KM, Godwin AK, Cukierman E. Ovarian normal and tumor-associated fibroblasts retain in vivo stromal characteristics in a 3-D matrix-dependent manner. Gynecol Oncol. 2008;110:99-109.
  • Stairs D, Nakagawa H, Klein-Szanto A, Mitchell S, Silberg D, Tobias J, Lynch J, Rustgi AK. Cdx1 and c-myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's Esophagus. PLoS ONE 3:e3534, 2008.
  • Tan Y, Timakhov RA, Rao M, Altomare DA, Xu J, Liu Z, Gao Q, Jhanwar SC, Di Cristofano A, Wiest DL, Knepper JE, Testa JR. A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice. Cancer Res. 2008;68:1296-302. Accepted prior to April 7, 2008.
  • Yeager N, Brewer C, Cai KQ, Xu XX, Di Cristofano A. Mammalian target of rapamycin is the key effector of phosphatidylinositol-3-OH-initiated proliferative signals in the thyroid follicular epithelium. Cancer Res. 2008;68:444-9. Accepted prior to April 7, 2008
  • Yu JJ, Robb VA, Morrison TA, Zriazi EA, Karbowniczek M, Astrinidis A, Wang C, Hernandez-Cuebas L, Seeholzer LF, Nicolas E, Hensley H, Jordan VC, Walker CL, Henske EP. Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells. Proc Natl Acad Sci USA. 2008;106:2635-40.

2007

  • Yeager N, Klein-Szanto A, Kimura S, Di Cristofano A. Pten Loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. Cancer Res. 2007;67:959-66.
  • Page R, Klein-Szanto AJ, Litwin S, Nicolas E, Al-Jumaily R, Alexander P, Godwin A, Ross E, Schilder R, Bassi DE. Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer. Cell. Oncol. 2007;29:289-99.
  • Makhortova N, Askovich P, Patterson CE, Gechman LA, Gerard NP, Rall GF. Neurokinin-1 enables measles virus trans-synaptic spread in neurons. Virology. 2007;362:235-44.
  • Macias E, Kim Y, Miliani de Marval P, Klein-Szanto A, Rodriguez-Puebla ML. Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis. Cancer Res. 2007;67:9713-20.
  • Johnson JE, Gettings EJ, Schwalm J, Pei J, Testa JR, Litwin S, von Mehren M, Broccoli D. Whole-genome profiling in liposarcomas reveals genetic alterations common to specific telomere maintenance mechanisms. Cancer Res. 2007;67:9221-8.
  • Huang Y, Fernandez S, Goodwin S, Russo PA, Russo IH, Sutter T, Russo J. Epithelial to mesenchymal transition in human breast epithelial cells transformed by 17-beta-estradiol. Cancer Res. 2007;67:11147-57.
  • Henry LR, Lee H, Lee JS, Klein-Szanto AJ, Watts P, Ross EA, Chen W, Cheng JD. Clinical implications of fibroblast activation protein in patients with colon cancer. Clin Cancer Res. 2007;13:1736-41.
  • Gumireddy K, Sun F, Klein-Szanto AJ, Gibbins JM, Saunders A, Schultz PG, Huang Q. Disulfide isomerase ERp5 promotes tumor invasion and metastasis by activating ErbB2/phosphoinositide-3 kinase pathways. Proc Natl Acad Sci USA. 2007;104:6696-6701.
  • Belinsky M, Klein-Szanto AJ, Kruh G. Multidrug resistance protein 4 (MRP4) protects bone marrow, thymus, spleen, and intestine from nucleotide analog-induced damage. Cancer Res. 2007;67:262-8.
  • Brewer C, Yeager N, Di Cristofano A. Thyroid-stimulating hormone-initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT. Cancer Res. 2007;67:8002-6.
  • Garland LL, Rankin C, Gandara D, Rivkin S, Scott K, Nagle R, Klein-Szanto A, Testa JR, Altomare D, Borden E. A Phase II study of Oral EGFR tyrosine kinase inhibitor erlotinib in patients with malignant pleural mesothelioma: a Southwest Oncology Group Study. J Clin Oncol. 2007;25:2406-13.
  • Mabuchi S, Altomare DA, Cheung M, Zhang L, Poulikakos PI, Hensley HH, Schilder RJ, Ozols RF, Testa JR. RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model. Clin Cancer Res. 2007;13:4261-70.
  • Mabuchi S, Altomare DA, Connolly DC, Klein-Szanto A, Litwin S, Hoelzle MK, Hensley HH, Hamilton TC, Testa JR. RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer. Cancer Res. 2007;67:2408-13. Priority Report.
  • Robb VA, Karbowniczek M, Klein-Szanto AJ, Henske EP. Activation of the mTOR signaling pathway in renal clear cell carcinoma. J Urol. 2007;177:346-52.
  • Xu R, Fang M, Klein-Szanto A, Sigal LJ. Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection. Proc Natl Acad Sci USA. 2007;104:10992-7.
  • Yang W, Cai K, Smedberg JL, Smith ER, Klein-Szanto A, Hamilton TC, Xu XX. A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice. Amer J Pathol. 2007;170:1325-36.
  • Yu Y, Fan J, Rouzer CA, Marnett LJ, Klein-Szanto AJ, FitzGerald GA, Funk CD. Targeted cyclooxygenase gene (Ptgs) exchange reveals discriminant isoform functionality. J Biol Chem. 2007;282:1498-1506.

2006

  • Xu C, Yamamoto Y, Zhou T, Aldrich CE, Frank K, Cullen JM, Jilbert AR, Mason WS. The liver of woodchucks chronically infected with woodchuck hepatitis virus contains foci of virus core antigen negative hepatocytes with both altered and normal morphology. Virology. 2006;359:283-94.
  • Vilgelm A, Lian Z, Wang H, Beauparlant S, Klein-Szanto A, Ellenson LH, Di Cristofano A. Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- Mice. Cancer Res. 2006;66:3375-80.
  • Smith MR, Joshi I, Jin F, Al-Saleem T. Murine model of mantle cell lymphoma. Leukemia. 2006;20:891-3.
  • Caslini C, Capo-Chichi CD, Roland IH, Nicolas E, Yeung AT, Xu XX. Histone modifications silence the GATA transcription factor genes in ovarian cancer. Oncogene. 2006 Aug 31;25(39):5446-61.
  • Cai K, Klein-Szanto A, Karthik D, Edelson M, Daly M, Ozols R, Lynch H, Godwin A, Xu X. Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations. Gynecol Oncol. 2006;103:719-28.
  • Andl CD, Fargnoli B, Okawa T, Bowser M, Takaoka M, Nakagawa H, Klein-Szanto A, Hua X, Herlyn M, Rustgi AK. Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo. Cancer Res. 2006;66:9878-85.
  • Chen Y, Weeks R, Burns M, Boorman D, Klein-Szanto A, O'Brien TG. Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma. Int J Cancer 2006;118:2344-9.
  • Fedele M, Fidanza V, Battista S, Pentimalli F, Klein-Szanto A, Visone R, De Martino I, Curcio A, Morisco C, Baldassarre G, Arra C, Viglietto G, Indolfi C, Croce C, Fusco, A. Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice. Cancer Res. 2006;66:2536-43.
  • Jones-Bolin S, Zhao H, Hunter K, Klein-Szanto A, Ruggeri BA. The effects of the oral, pan-VEGF-R kinase inhibitor CEP-7055 and chemotherapy in orthotopic models of glioblastoma and colon carcinoma in mice. Mol Cancer Ther. 2006;5:1744-53.
  • Kim S, Nakagawa H, Navaraj A, Naomoto Y, Klein-Szanto A, Rustgi AK, El-Deiry WS. Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras. Cancer Res. 2006;66:10415-24.
  • Lin DI, Barbash O, Suresh Kumar K, Weber J, Harper JW, Klein-Szanto AJ, Rustgi A, Fuchs SY, Diehl JA. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-αB Crystallin complex. Mol Cell. 2006;24:365-6.
  • Robb VA, Astrinidis A, Henske EP. Frequent hyperphosphorylation of ribosomal protein S6 in lymphangioleiomyomatosis-associated angiomyolipomas. Mod Pathol. 2006;19:839-46.
  • Yu Y, Fan J, Chen X, Wang D, Klein-Szanto A, FitzGerald G, Funk CD. Genetic model of selective COX2 inhibition reveals novel heterodimer signaling and thromboembolic risk. Nat Med. 2006;12:699-704.

2005

  • Yu Y, Chen XS, Klein-Szanto A, FitzGerald GA, Funk CD. Differential platelet and parturition response from diminished prostaglandin levels in mice harboring a hypmorphic prostaglandin H synthase allele. J Clin Invest. 2005;115:986-95.
  • Yang WL, Roland IH, Godwin AK, Xu XX. Loss of TNF-alpha-regulated COX‑2 expression in ovarian cancer cells. Oncogene. 2005;24:7991-8002.
  • Yang D-H, Fazili Z, Smith ER, Cai QK, Klein-Szanto A, Cohen C, Horowitz I, Xu XX. Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53 Null background. Amer J Pathol. 2006;169:258-67.
  • Wang L, Chen X, Tang B, Hua X, Klein-Szanto A, Kruger WD. Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Hum Mol Genet. 2005;14:2201-8.
  • Wang HQ, Altomare DA, Skele KS, Di Cristofano A, Kuhajda FP, Testa JR. Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene. 2005;24:3574-82.
  • Mason WS, Jilbert AR, Summers J. Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection. Proc Natl Acad Sci USA. 2005;102:1139-44.
  • López de Cicco R, Bassi DE, Zucker S, Seidah NG, Klein-Szanto AJ. Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin. Cancer Res. 2005;65:4162-71.
  • Fedele M, Pentimalli F, Baldassarre G, Battista S, Klein-Szanto A, Kenyon L, Visone R, Azimi N, Viglietto G, Croce C, Fusco A. Transgenic mice overexpressing the wild type form of the HMGA1 gene develop a mixed growth hormone/prolactin cell pituitary adenomas and Natural Killer Cell Lymphomas. Oncogene 2005;24:3427-35.
  • Capo-Chichi CD, Rula ME, Smedberg JL, Vanderveer L, Parmacek MS, Morrisey EE, Godwin AK, Xu XX. Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells. Dev Biol. 2005;286:574-86.
  • Cacciotti P, Barbone D, Porta C, Altomare DA, Testa JR, Mutti L, Gaudino G. SV40-dependent AKT activity drives mesothelial cell transformation after asbestos exposure. Cancer Res. 2005;65:5256-62.
  • Belinsky MG, Dawson PA, Shchaveleva I, Bain LJ, Wang R, Ling V, Chen ZS, Grinberg A, Westphal H, Klein-Szanto A, Lerro A, Kruh GD. Analysis of the in vivo functions of Mrp3. Mol Pharmacol. 2005;68:160-8.
  • Altomare DA, Vaslet CA, Skele KL, De Rienzo A, Devarajan K, Jhanwar SC, McClatchey AI, Kane AB, Testa JR. A mouse model recapitulating molecular features of human mesothelioma. Cancer Res. 2005;65:8090-5.
  • Altomare DA, You H, Xiao G-H, Ramos-Nino ME, Skele KL, De Rienzo A, Jhanwar SC, Mossman BT, Kane AB, Testa JR. Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth. Oncogene. 2005;24:6080-9.
  • Amatangelo MD, Bassi DE, Klein-Szanto A, Cukierman E. Stroma-derived 3‑D matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. Am J Pathol. 2005;167:475-88.
  • Bassi DE, Lopez de Cicco R, Cenna J, Cukierman E, Klein-Szanto A. PACE 4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression. Cancer Res. 2005;65:7310-9, 2005.