Faculty Summaries
Daniel E Bassi, PhD
Daniel E Bassi, PhD
Assistant Research Professor
Office Phone: 215-728-3155
Office: C417


  • Fu J, Bassi DE, Zhang J, Li T, Nicolas E, Klein-Szanto AJ Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth. Neoplasia. 2012 Apr;14(4):271-82.
  • Cukierman E, Bassi DE The mesenchymal tumor microenvironment: a drug-resistant niche. Cell Adh Migr. 2012 May-Jun;6(3):285-96. Epub 2012 May 1. Review
  • Gupta V, Bassi DE, Simons JD, Devarajan K, Al-Saleem T, Uzzo RG, Cukierman E. Elevated expression of stromal palladin predicts poor clinical outcome in renal cell carcinoma. PLoS One. 2011;6(6):e21494. doi: 10.1371/journal.pone.0021494. Epub 2011 Jun 28.
  • Related citationsBassi, DE, Jirong Zhang, Jonathan Cenna, Samuel Litwin, Edna Cuckierman and Andres J Klein-Szanto.Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis. Neoplasia, 2010, Jul 1.
  • Cukierman E, Bassi DE Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors. Semin Cancer Biol. 2010 May 7.
  • Fu J, Jin F, Zhang J, Fong K, Bassi DE, Lopez De Cicco R, Ramaraju D, Braunewell KH, Conti C, Benavides F, Klein-Szanto AJ. VILIP-1 expression in vivo results in decreased mouse skin keratinocyte proliferation and tumor development. PLoS One. 2010 Apr 15;5(4).
  • Fu J, Fong K, Bellacosa A, Ross E, Apostolou S, Bassi DE, Jin F, Zhang J, Cairns P, Ibañez de Caceres I, Braunewell KH, Klein-Szanto AJ.. VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival. PLoS ONE. 2008 Feb 27;3(2):e1698
  • Daniel E. Bassi and A.J.P. Klein-Szanto, Carcinogen Induced Animal Models of Head and Neck Squamous Cell Carcinoma. Current Protocols in Pharmacology, (2007). 14.2.1-14.2.19
  • Page RE, Klein-Szanto AJ, Litwin S, Nicolas E, Al-Jumaily R, Alexander P, Godwin AK, Ross EA, Schilder RJ, Bassi DE. Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer. Cell Oncol. 2007;29(4):289-99.
  • Ricardo López de Cicco , Daniel E. Bassi, Fernando Benavides , Claudio J. Conti , Andrés J.P. Klein-Szanto. Inhibition of proprotein convertases: Approaches to block squamous carcinoma development and progression..Mol Carc. (2007) Apr 17.
  • Khatib AM, Bassi D, Siegfried G, Klein-Szanto AJ, Ouafik L. Endo/exo-proteolysis in neoplastic progression and metastasis. J Mol Med. 2005 Nov;83(11):856-64. Epub 2005 Aug 26
  • Bassi DE, Fu J, Lopez de Cicco R, Klein-Szanto AJ. Proprotein convertases: "Master switches" in the regulation of tumor growth and progression. Mol Carcinog. 2005 Sep 15;44(3):151-161
  • Bassi DE, Lopez De Cicco R, Cenna J, Litwin S, Cukierman E and. Klein-Szanto AJ.P. PACE4 Expression in Mouse Basal Keratinocytes Results in Basement Membrane Disruption and Acceleration of Tumor Progression. Cancer Research, 2005, 65: (16)7310-7319.
  • Amatengelo, M; Bassi, DE, Klein-Szanto, AJP and Cukierman, E. Stroma-derived Three-Dimensional Matrices are necessary and sufficient to promote Desmoplastic Differentiation of Normal Fibroblasts. 2005. American Journal of Pathology, 2005, Aug; 167 (2), 475-88.
  • Lopez de Cicco R, Bassi DE, Zucker S, Seidah NG and Klein-Szanto AJP. Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin. Cancer Res. 2005 May 15, 65 (10): 4162-71.
  • Lopez de Cicco R, Watson JC, Bassi DE, Litwin S, Klein-Szanto AJ. Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression. Clin Cancer Res. 2004 Jul 1;10(13):4480-8.
  • Lopez de Cicco R, Bassi DE, Page R, Klein-Szanto AJ. Furin expression in squamous cell carcinomas of the oral cavity and other sites evaluated by tissue microarray technology. Acta Odontol Latinoam. 2002;15(1-2):29-37.
  • Mahloogi H, Gonzalez-Guerrico AM, Lopez De Cicco R, Bassi DE, Goodrow T, Braunewell KH, Klein-Szanto AJ. Overexpression of the calcium sensor visinin-like protein-1 leads to a cAMP-mediated decrease of in vivo and in vitro growth and invasiveness of squamous cell carcinoma cells. Cancer Res. 2003 Aug 15;63(16):4997-5004.
  • Bassi, D.E; Mahloogi, H; López de Cicco, R. and Klein-Szanto, A. Increased furin activity enhances the malignant phenotype of human cancer cells. American Journal of Pathology 2003 Feb ; 162 (2): 439
  • Liu SC, Bassi DE, Zhang SY, Holoran D, Conti CJ, Klein-Szanto AJ. Overexpression of cyclin D2 is associated with increased in vivo invasiveness of human squamous carcinoma cells. Mol Carcinog 2002 Jul;34(3):131-9.
  • Mercapide, J; López de Cicco, R; Bassi, D.E and Klein-Szanto, A.J.P. Inhibition of furin- a. mediated processing results in suppression of astrocytoma cell growth and invasiveness. Clinical b. Cancer Research. 2002 Jun;8(6):1740-6.
  • Mahloogi, H; Bassi, D.E. and Klein-Szanto, A.J.P. Malignant Conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE-4. Carcinogenesis 2002 Apr;23(4):565-72.
  • Vojnov, A; Bassi, D.E.; Daniels, MJ and Dankert, MA Biosynthesis of a substituted cellulose from a mutant strain of Xanthomonas campestris. Carbohydr. Res. (2002) 337:315-26.
  • Daniel E. Bassi, Ricardo Lopez De Cicco, Haleh Mahloogi, Stanley Zucker, Gary Thomas and Andres J.P. Klein-Szanto Furin Inhibition Results in Absent or Decreased Invasiveness and Tumorigenicity of Human Cancer Cells. Proceedings of the National Academy of Sciences. (2001) 98: 10326-31.
  • Bassi, DE; Mahloogi, H; Al-Saleem L, Lopez R; Ridge J and Klein-Szanto, A.Furin expression is associated with increased aggressiveness in human head and neck cell lines. Molecular Carcinogenesis, 31:224-232 (2001).
  • Bassi, DE, Mahloogi, H ands Klein-Szanto, A. Proprotein convertases Furin and PACE4 play a significant role in tumor progression. Molecular Carcinogenesis, 28: 63-69. 2000.
  • Riccio A, Aaltonen LA, Godwin AK, Loukola A, Percesepe A, Salovaara R, Masciullo V, Genuardi M, Paravatou-Petsotas M, Bassi DE, Ruggeri BA, Klein-Szanto AJ, Testa JR, Neri G, Bellacosa A. The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatelite instability. Nat Genet. 1999;23: 266-8
  • I.O. Mastronardi, A. Vojnov, D.E. Bassi and M.A. Dankert.A new galacturonide from Xanthomonas campestris PV campestis, strain 8237. An Asoc. Quím. Argent, (1993) 81, 77-87.
  • A. Faletti, D.E. Bassi, A.M. Franchi, A.L. Gimeno and M.A.F. Gimeno Effects of ß-endorphin on spontaneous uterine contractions, prostaglandins production and 45Ca+2 - uptake in uterine strips from ovariectomized rats. Prostaglandins, Leukotrienes and Essential Fatty Acids, (1992), 42, 234
  • A. Faletti, D.Bassi, A.M. Franchi, A.L. Gimeno and M.A.F. Gimeno. Effects of Morphine on Arachidonic Acid metabolism, on Ca2+ - uptake and on c-AMP synthesis in uterine strips of spayed rats. Prostaglandins, Leukotrienes and Essential Fatty Acids, (1990), 41, 151- 155.
  • A.M. Fanchi, M. Chaud, A. Faletti, D.E. Bassi, M.A.F. Gimeno and A.L. Gimeno Oxytocin enhances the basal release of uterine Prostaglandin F2 but not that of PGE1, or of PGE2, and changes the metabolism of exogenous Arachidonate, favoring the formation of Prostaglandin F2, and HETE. Relationships with its uterotronic action and modulation by Estradiol. Prostaglandins, Leukotrienes and Essential Fatty Acids, (1990), 40, 203-209.