Faculty Summaries
Alfonso Bellacosa, MD, PhD
Alfonso Bellacosa, MD, PhD
  • Adjunct Associate Professor, Department of Biochemistry, Drexel University College of Medicine
  • Adjunct Professor, College of Science and Technology, Temple University
  • Adjunct Associate Professor, Department of Microbiology and Immunology, Temple University School of Medicine
Office Phone: 215-728-4012
Lab Phone: 215-728-4013
Fax: 215-214-1590
Office: P3041
Lab: P3023

Research Interests

  • Role of DNA Repair in the stability of the genome and epigenome.
  • Regulation of DNA methylation and DNA demethylation in development and cancer.
  • Targeted epigenetic therapy
  • Hereditary Cancer
Description of research projects
Selected Publications
    1. Tricarico, R., Cortellino, S., Riccio, A., Jagmohan-Changur, S., van der Klift, H., Wijnen, J., Turner, D., Ventura, A., Rovella, V., Percesepe, A., Lucci-Cordisco, E., Radice, P., Bertario, L., Pedroni, M., Ponz de Leon, M., Mancuso, P., Devarajan, K., Cai, K.Q., Klein-Szanto, A.J.P., Neri, G., Møller, P., Viel, A., Genuardi, M., Fodde, R. and Bellacosa, A. Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. In press, Oncotarget.
    3. Bellacosa, A. and Drohat A.C. Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites. (Invited Review) DNA Repair, 32:33-42 (2015).
    5. Bellacosa, A. Developmental disease and cancer: biological and clinical overlaps. (Invited Review) Am J Med Genet A, 161:2788-96 (2013).
    7. Dalton, S.R. and Bellacosa, A. DNA Demethylation by TDG. Epigenomics 4: 459-467 (2012).
    9. Cortellino, S., Xu, J., Sannai, M., Moore, R., Caretti, E., Cigliano, A., Le Coz, M., Devarajan, K., Wessels, A., Soprano, D., Abramowitz, L. K., Bartolomei, M.S. Rambow, F., Bassi, M.R., Bruno, T., Fanciulli, M., Renner, C., Klein-Szanto, A.J., Matsumoto, Y., Kobi, D., Davidson, I., Alberti, C., Larue, L., Bellacosa, A. Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell 146:67-79 (2011).
    11. Bellacosa, A., Godwin, A.K., Peri, S., Devarajan, K., Caretti, E., Vanderveer, L., Bove, B., Slater, C., Zhou, Y., Daly, M., Howard, S., Campbell, K., Nicolas, E., Yeung, A.T., Clapper, M.L., Crowell, J.A., Lynch, H.T., Ross, E., Kopelovich, L., Knudson, A.G. Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations. Cancer Prev. Res. 3: 48–61 (2010).
    13. Howard, J.H., Frolov, A., Tzeng, C-W.D., Stewart, A., Midzak, A., Majmundar, A., Godwin, A.K., Heslin, M.J., Bellacosa, A., and Arnoletti, J.P. Epigenetic Downregulation of the DNA Repair Gene MED1/MBD4 in Colorectal and Ovarian Cancer. Cancer Biol. Ther. 8: 1-7 (2009).
    15. Cortellino, S., Wang, C., Wang, B., Bassi, M.R., Caretti, E., Champeval, D., Calmont, A., Jarnik, M., Burch, J., Zaret, K., Larue, L., Bellacosa, A. Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4. Dev. Biol. 325: 225-237 (2009). PMC2645042 Caretti, E., Devarajan, K., Coudry, R., Ross, E., Clapper, M.L., Cooper, H.S. and Bellacosa, A. Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection. J. Cell. Biochem. 103: 556-563 (2008).
    17. Julien, S., Puig, I., Caretti, E., Bonaventure, J., Nelles, L., van Roy, F., Dargemont, C., Garcia de Herreros, A., Bellacosa, A. and Larue, L. Activation of NF-kB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene 26: 7445-7456 (2007).
    19. Turner, D.P., Cortellino, S., Schup, J.E., Caretti, E., Loh, T., Kinsella, T.J., Bellacosa, A. The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine. Cancer Res. 66: 7686-7693 (2006). Bellacosa, A., Kumar, C.C., Di Cristofano, A., Testa, J.R. Activation of AKT kinases in cancer: implications for therapeutic targeting. Adv. Cancer Res. 94: 29-86, 2005. Larue, L. and Bellacosa, A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene 24: 7443-7454, 2005.
All publications