Faculty Summaries
Jeff Boyd, PhD
Jeff Boyd, PhD
  • Senior Vice President, Molecular Medicine
  • The Robert C. Young, MD, Chair in Cancer Research
  • Chief, Division of Molecular Pathology
  • Professor, Cancer Biology Program
Office Phone: 215-728-2907
Lab Phone: 215-214-4053
Office: R252
Lab: R354
Molecular Genetics of Women's Cancers

Research in our laboratory is directed generally toward understanding the molecular genetics and genetics of women's cancers, specifically those of the ovary, endometrium, and breast. Past work has focused on genetic predisposition to these cancers, including the BRCA-related breast and ovarian cancer syndrome and the hereditary nonpolyposis colorectal cancer syndrome (HNPCC or Lynch syndrome) and on defining the somatic molecular alterations relevant to the tumorigenic process in these sites. Currently, we are actively engaged in three projects: 1) studying the early natural history of ovarian cancer, especially the development of chromosomal abnormalities as a very early event in ovarian tumorigenesis; 2) defining the role of the CA125 biomarker (encoded by the MUC16 gene) in ovarian tumorigenesis; and 3) investigating a novel mechanism through which estrogen is carcinogenic at the molecular level, i.e., through the estrogen receptor-mediated silencing of critical tumor suppressor gene expression.

Description of research projects
Selected Publications

Fox Chase Programs

  1. Pothuri B, Leitao MM, Levine DA, Viale A, Olshen AB, Arroyo C, Bogomolniy F, Olvera N, Lin O, Soslow RA, Robson ME, Offit K, Barakat RR, Boyd J. Genetic analysis of the early natural history of ovarian carcinoma. PLoS ONE. 2010; e10358. PLoS ONE
  2. Olshen AB, Gold B, Lohmueller KE, Struewing JP, Satagopan J, Stefanov SA, Eskin E, Kirchhoff T, Lautenberger JA, Friedman E, Norton L, Ellis NA, Viale A, Lee CS, Borgen PI, Clark AG, Offit K, Boyd J. Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping. BMC Genetics. 2008;9:14. PubMed
  3. King TA, Li W, Brogi E, Yee CJ, Gemignani ML, Olvera N, Levine DA, Norton L, Robson ME, Offit K, Boyd J. Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis. Ann Surg Oncol. 2007;14:2510-8. PubMed
  4. Black D, Soslow RA, Levine DA, Tornos C, Chen SC, Hummer AJ, Bogomolniy F, Olvera N, Barakat RR, Boyd J. The clinicopathologic significance of defective DNA mismatch repair in endometrial carcinoma. J Clin Oncol. 2006;24:1745-53. PubMed
  5. Jazaeri AA, Awtrey CS, Gadisetti CVR, Chuang YE, Khan J, Sotiriou C, Aprelikova O, Yee CJ, Zorn KK, Birrer MJ, Barrett CJ, Boyd J. Gene expression profiles associated with response to chemotherapy in epithelial ovarian cancers. Clin Cancer Res. 2005;11:6300-10. PubMed
  6. Ferguson SE, Olshen AB, Viale A, Barakat RR, Boyd J. Stratification of intermediate risk endometrial cancer patients into groups at high- or low-risk for recurrence based on tumor gene expression profiles. Clin Cancer Res. 2005;11:2252-7. PubMed
  7. King TA, Gemignani ML, Li W, Tan LK, Giri DD, Panageas KS, Bogomolniy F, Arroyo C, Olvera N, Robson ME, Offit K, Borgen PI, Boyd J. Aberrant progesterone receptor expression in breast epithelium of BRCA1 mutation carriers. Cancer Res. 2004;64:5051-3.
All publications